Fatalities caused by TRALI

Holness, Leslie; Knippen, Maureen; Simmons, Lois; Lachenbruch, Peter A.

doi:10.1016/j.tmrv.2004.03.004

Cited by 303 publications

(230 citation statements)

References 13 publications

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“…In the initial study by Popovsky and Moore (1985), 31 out of 36 TRALI cases occurred in patients with surgical procedures, requiring blood transfusion either during surgery (n ¼ 24) or caused by postoperative blood loss (n ¼ 7), and only five out of 36 TRALI cases occurred in patients with anaemia for chronic or stable conditions. These data were corroborated by others, and active infection, cardiovascular disease and leukaemia were identified as additional risk factors (Silliman et al, 1997;Silliman et al, 2003a;Holness et al, 2004). It should be kept in mind that linking TRALI to any specific clinical event needs valid denominator data.…”

Section: Priming Of Neutrophils Owing To Underlying Co-morbiditysupporting

confidence: 63%

“…It has been thanks to the British Serious Hazards of Transfusion (SHOT) haemovigilance system that the recognition of TRALI has gained increased recognition. In recent years, TRALI has been reliably shown to be the most common cause of transfusion-related fatalities in the United States and in the United Kingdom (Holness et al, 2004;Stainsby et al, 2004). This review summarises the current knowledge on the pathogenesis of TRALI.…”

Section: Discussionmentioning

confidence: 99%

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The pathogenesis of transfusion‐related acute lung injury (TRALI)

2007

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SummaryIn recent years, transfusion-related acute lung injury (TRALI) has developed from an almost unknown transfusion reaction to the most common cause of transfusion-related major morbidities and fatalities. A clinical definition of TRALI was established in 2004, based on acute respiratory distress, noncardiogenic lung oedema temporal association with transfusion and hypoxaemia. Histological findings reveal lung oedema, capillary leucostasis and neutrophil extravasation. However, the pathogenesis of TRALI remains controversial. Leucocyte antibodies, present in fresh frozen plasma and platelet concentrates from multiparous donors, and neutrophil priming agents released in stored cellular blood components have been considered to be causative. As neutrophils and endothelial cells are pivotal in the pathogenesis of TRALI, a threshold model was established to try to unify the various reported findings on pathogenesis. This model comprises the priming of neutrophils and/or endothelium by the patient's co-morbidity, neutrophil and/or endothelial cell activation by the transfused blood component, and the severity of the TRALI reaction.

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Section: Priming Of Neutrophils Owing To Underlying Co-morbiditysupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

The pathogenesis of transfusion‐related acute lung injury (TRALI)

2007

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“…[1][2][3][4] Despite the implementation of TRALI mitigation strategies for plasma and platelet concentrates (PCs), which employ either male-only and/or "antibody-negative" donors, there are still significant numbers of TRALI-related deaths, especially linked to the transfusion of red blood cell (RBC) units. 1,2,4,5 TRALI has been reported to be the result of at least 2 events: the first pertaining to the clinical condition of the patient, and the second to the infusion of antibodies that recognize human lymphocyte antigen (HLA) class I, class II, or granulocyte antigens or the infusion of biological response modifiers, which include both biologically active lipids and soluble CD40 ligand (sCD40L).…”

Section: Introductionmentioning

confidence: 99%

Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo

Silliman

Kelher

Khan³

et al. 2014

Blood

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Key Points• TRALI may be induced by antibodies to HLA or HNA antigens or lipids, which accumulate during storage.• Prestorage experimental filtration of RBCs removes HLA and HNA antibodies, decreases lipid priming activity, and mitigates TRALI in an animal model.Transfusion-related acute lung injury (TRALI) remains a significant cause of transfusionrelated mortality with red cell transfusion. We hypothesize that prestorage filtration may reduce proinflammatory activity in the red blood cell (RBC) supernatant and prevent TRALI. Filters were manufactured for both small volumes and RBC units. Plasma containing antibodies to human lymphocyte antigen (HLA)-A2 or human neutrophil antigen (HNA)-3a was filtered, and immunoglobulins and specific HNA-3a and HLA-2a neutrophil (PMN) priming activity were measured. Antibodies to OX27 were added to plasma, and filtration was evaluated in a 2-event animal model of TRALI. RBC units from 31 donors known to have antibodies against HLA antigens and from 16 antibody-negative controls were filtered. Furthermore, 4 RBC units were drawn and underwent standard leukoreduction. Immunoglobulins, HLA antibodies, PMN priming activity, and the ability to induce TRALI in an animal model were measured. Small-volume filtration of plasma removed >96% of IgG, antibodies to HLA-A2 and HNA-3a, and their respective priming activity, as well as mitigating antibodymediated in vivo TRALI. In RBC units, experimental filtration removed antibodies to HLA antigens and inhibited the accumulation of lipid priming activity and lipid-mediated TRALI. We conclude that filtration removes proinflammatory activity and the ability to induce TRALI from RBCs and may represent a TRALI mitigation step. (Blood. 2014;123(22):3488-3495)

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“…[1][2][3][4] TRALI is defined as the acute onset of hypoxia and bilateral pulmonary infiltrates, in temporal relation to a blood transfusion. 1,5 Although the absence of specific disease markers and diagnostic tests has resulted in a large variation in estimations of incidence, 1,[6][7][8][9][10][11][12][13][14] TRALI is generally considered to be a rare event.…”

Section: Introductionmentioning

confidence: 99%