Fatal Zika Virus Infection with Secondary Nonsexual Transmission

Swaminathan, Sankar; Salais, Robert; Lewis, Julia B.; Hanson, Kimberly E.; Couturier, Marc Roger

doi:10.1056/nejmc1610613

Cited by 157 publications

(134 citation statements)

References 4 publications

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“…Our work also draws attention to the necessity of better investigating the ocular disorders associated with ZIKV-infected patients and to evaluate the risk of transmission by eye or tear contact, as has recently been suggested (16). …”

mentioning

confidence: 99%

Zika Virus Efficiently Replicates in Human Retinal Epithelium and Disturbs Its Permeability

Salinas

Erkilic

Damodar

et al. 2017

J Virol

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mentioning

confidence: 99%

Zika Virus Efficiently Replicates in Human Retinal Epithelium and Disturbs Its Permeability

Salinas

Erkilic

Damodar

et al. 2017

J Virol

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“…sion can also occur through sexual contact, vertically, through blood transfusion, and possibly via secondary, nonsexual contact (5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

Serologic Testing for Zika Virus: Comparison of Three Zika Virus IgM-Screening Enzyme-Linked Immunosorbent Assays and Initial Laboratory Experiences

et al. 2017

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Serologic evaluation for Zika virus (ZIKV) infection currently includes an initial screen using an anti-ZIKV IgM antibody capture enzyme-linked immunosorbent assay (MAC-ELISA) followed by supplemental testing of specimens with nonnegative results by a plaque reduction neutralization test (PRNT). We compared the performance characteristics of three ELISAs for the detection of IgM class antibodies to ZIKV, including the Centers for Disease Control and Prevention (CDC) Zika MAC-ELISA, the InBios ZIKV Detect MAC-ELISA, and the Euroimmun anti-Zika Virus IgM ELISA. Additionally, we present our initial experiences with ZIKV serologic testing from a national reference laboratory perspective. Using both retrospectively and prospectively collected specimens from patients with possible ZIKV infection, we show that the CDC and InBios MAC-ELISAs perform comparably to each other, with positive agreement, negative agreement, and interrater kappa values ranging from 87.5% to 93.1%, 95.7% to 98.5%, and 0.52 to 0.83, respectively. In contrast, comparison of the Euroimmun ZIKV ELISA to either the CDC or InBios MAC-ELISAs resulted in positive agreement, negative agreement, and interrater kappa values ranging from 17.9% to 42.9%, 91.7% to 98.6%, and 0.10 to 0.39, respectively. Among the 19 prospective samples submitted for PRNT, nine were negative, eight specimens had neutralizing antibodies to a flavivirus (unable to be identified), and one sample each was confirmed for ZIKV or dengue virus infection. This study highlights the ongoing challenges associated with serologic diagnosis of ZIKV infection. Although the availability of a commercial serologic test for ZIKV has greatly expanded the national capacity for such testing, the need to further characterize and improve these assays, particularly with regard to specificity, remains. KEYWORDS Zika virus, serologyZ ika virus (ZIKV) emerged from obscurity in early 2015 following its detection in Bahia, Brazil (1). Over the next year, ZIKV spread rapidly throughout Latin America, the Caribbean, and into the southern United States, resulting in a major and still ongoing international outbreak (2). Currently, over 1 million cases of suspected or confirmed ZIKV infection have been documented in the Americas by the Pan American Health Organization (3). ZIKV, a single-stranded RNA virus and member of the Flavivirus genus, is primarily transmitted through infected Aedes species mosquitoes, which are also primary vectors for dengue (DENV) and chikungunya (CHIKV) viruses, both of which cocirculate in many regions where ZIKV is now considered endemic (4). ZIKV transmis-

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“…Ekim 2016'da Meksika'dan bildirilen bir olgu sunumunda ZVH nedeniyle ölen bir olguya eldivensiz temasla bulaşma olduğu bildirilmiştir. Bulaşma olan olgunun, ZVH yönünden endemik olan bölgeye seyahat, seyahat eden bir kişiyle cinsel temas, kan transfüzyo-nu ya da sivrisinek sokması öyküsünün olmadığı belirtilmiştir (22). ZV'nin insandan insana bulaştığı ülkelerin listesine Şubat 2016'dan sonra bir ay içinde 13 ülke daha eklenmiştir (7).…”

Section: Sivrisinek Yoluyla Bulaşma: Zv'nin Başlıca Bulaşma Yoluunclassified

Zika Virus Disease: The Situation in Turkey and a Review of the Worldwide Outbreak

Sari¹

2017

Klimik Dergisi

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Fatal Zika Virus Infection with Secondary Nonsexual Transmission

Cited by 157 publications

References 4 publications

Zika Virus Efficiently Replicates in Human Retinal Epithelium and Disturbs Its Permeability

Zika Virus Efficiently Replicates in Human Retinal Epithelium and Disturbs Its Permeability

Serologic Testing for Zika Virus: Comparison of Three Zika Virus IgM-Screening Enzyme-Linked Immunosorbent Assays and Initial Laboratory Experiences

Zika Virus Disease: The Situation in Turkey and a Review of the Worldwide Outbreak

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