Fatal Visceral and Neural Sarcocystosis in Dogs

Trasti, Scott L.; Dubey, J. P.; Webb, D M; Blanchard, Terrell W.; Britt, James O.; Fritz, David L.; Lewis, Robert M.

doi:10.1053/jcpa.1999.0307

Cited by 15 publications

(19 citation statements)

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“…The Sarcocystis species found in these dogs have not been named or definitely identified. Infections with Sarcocystis canis , and Sarcocystis neurona have been reported in dogs . S. canis was first described in 1991 .…”

Section: Discussionmentioning

confidence: 99%

“…S. canis was named to draw attention to the severe hepatitis it causes in dogs and other animals; the only stage known is the schizont . Encephalitis, dermatitis, and pneumonia also have been reported in dogs infected with S. canis , with most reports involving puppies . Sarcocystis neurona is an unusual species with opossums as definitive hosts and several other animal species, including dogs, cats, marine mammals, and horses, as intermediate or aberrant hosts .…”

Section: Discussionmentioning

confidence: 99%

“…Infections with Sarcocystis canis, and Sarcocystis neurona have been reported in dogs. [14][15][16][17][18] S. canis was first described in 1991. 15 The complete life cycle of S. canis is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…15,17 Encephalitis, dermatitis, and pneumonia also have been reported in dogs infected with S. canis, with most reports involving puppies. 15,16,18 Sarcocystis neurona is an unusual species with opossums as definitive hosts and several other animal species, including dogs, cats, marine mammals, and horses, as intermediate or aberrant hosts. 10,19 There are numerous reports of severe S. neurona-like infections in animals, usually with central nervous system signs associated with schizont stage.…”

Section: Discussionmentioning

confidence: 99%

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Severe Myositis Associated with Sarcocystis spp. Infection in 2 Dogs

Sykes

Dubey

Lindsay

et al. 2011

Veterinary Internal Medicne

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Background: Dogs are definitive hosts for numerous species of the intracellular protozoan parasite Sarcocystis. Reports of sarcocysts in muscles of dogs most often represent incidental findings.Hypothesis/Objectives: To report the clinicopathologic, ultrastructural, and molecular findings in 2 dogs with myositis associated with Sarcocystis spp. infection, as well as the response to treatment with antiprotozoal drugs.Animals: Two dogs with severe myositis in association with massive sarcocystosis. Methods: Retrospective case review. Affected dogs were identified by a diagnostic laboratory. Attending clinicians were contacted, and the medical records reviewed. Immunostaining and electron microscopy were performed on muscle biopsies. Biopsies also were subjected to 18S rRNA gene PCR.Results: Both dogs had fever, lymphopenia, thrombocytopenia, and increased serum alanine aminotransferase (ALT) activity when first evaluated. One dog developed hyperbilirubinemia. Subsequently, both dogs had increased serum creatine kinase activity and clinical signs of myositis, with reluctance to move, generalized pain, and muscle wasting. Histopathology of muscle biopsies showed severe inflammatory and necrotizing myopathy with numerous sarcocysts. Ultrastructural studies and 18S rRNA gene sequence results were consistent with infection with a Sarcocystis spp. other than Sarcocystis neurona. Both dogs initially were treated unsuccessfully with clindamycin and anti-inflammatory drugs. One dog died. The other dog subsequently responded to treatment with decoquinate.Conclusions and Clinical Importance: Sarcocystis spp. infection should be included in the differential diagnosis for dogs that develop fever, thrombocytopenia, increased liver enzyme activities, and clinical and biochemical evidence of myositis. Although additional studies are required, decoquinate holds promise as an effective treatment for the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Severe Myositis Associated with Sarcocystis spp. Infection in 2 Dogs

Sykes

Dubey

Lindsay

et al. 2011

Veterinary Internal Medicne

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“…Furthermore, the protozoan seen in this dog was not found outside the brain, unlike reports with S. canis-like protozoans. 13,15 To our knowledge, S. neurona encephalitis has not been documented previously in the dog. The morphology, central nervous system tissue tropism, immunohistochemical reactivity, and DNA analysis support the definitive diagnosis of S. neurona in this dog.…”

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confidence: 80%

Sarcocystis neurona Encephalitis in a Dog

Cooley

Barr

Rejmanek³

2007

Vet Pathol

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Abstract. A 1.5-year-old male Feist dog was presented to a veterinarian for reluctance to stand on the hind legs. Treatment included dexamethasone and resulted in a favorable initial response, but posterior paresis returned and progressed to recumbency, hyperesthesia, and attempts to bite the owner. The dog was euthanized. The brain was negative for rabies by fluorescent antibody analysis. Multiple foci of encephalitis were found in the cerebrum and particularly in the cerebellum. Protozoa morphologically consistent with Sarcocystis sp. were identified at sites of intense inflammation and malacia. Additionally, multiple schizonts were identified in areas without inflammation. Immunohistochemistry using both polyclonal and monoclonal antibodies specific for Sarcocystis neurona was strongly positive. No reaction to polyclonal antisera for Toxoplasma gondii or Neospora caninum was found. Polymerase chain reaction confirmed that the protozoa were S. neurona. Additional aberrant hosts for S. neurona other than horses have been identified, but S. neurona encephalitis has not been documented previously in the dog.

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Sarcocystosis

Dubey¹,

Sykes²

2021

Greene's Infectious Diseases of the Dog and Cat

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Fatal Visceral and Neural Sarcocystosis in Dogs

Cited by 15 publications

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Severe Myositis Associated with Sarcocystis spp. Infection in 2 Dogs

Severe Myositis Associated with Sarcocystis spp. Infection in 2 Dogs

Sarcocystis neurona Encephalitis in a Dog

Sarcocystosis

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