Fatal varicella with primary fibrinolysis in a renal transplant recipient

Franco, Antônio; Marco, Pascual; Gil, Célia; Muñoz, Cecilia; Jiménez, L.; Andreu, Mariano García; Olivares, José

doi:10.1093/ndt/14.5.1291

Cited by 6 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The complications of varicella infection post‐renal Tx are well‐documented, and include dissem‐inated infection, acute renal failure, rejection, graft loss, and death (1–13, 19). Such complications may develop even with appropriate management using post‐exposure VZIG prophylaxis, treatment with i.v.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pretransplant varicella vaccination is cost‐effective in pediatric renal transplantation

Olson

Shope

Flynn

2001

Pediatric Transplantation

View full text Add to dashboard Cite

Because of the severe complications that may result from varicella zoster virus (VZV) infection following renal transplantation (Tx), transplanted varicella-susceptible children exposed to varicella are typically given varicella zoster immunoglobulin (VZIG) as prophylaxis or are admitted and treated with parenteral acyclovir if VZIG prophylaxis fails. As both VZIG and hospitalization are costly, prevention of varicella infection by vaccination could potentially result in significant cost savings in addition to decreasing morbidity and mortality. To test this hypothesis, we developed a decision-analysis model to evaluate the cost-effectiveness of vaccinating patients with chronic renal failure (CRF) against varicella prior to renal transplant. Under baseline assumptions, vaccination for varicella pretransplant was a cost-effective strategy, with a cost of $211 per patient vaccinated compared with $1,828 per patient not vaccinated. The magnitude of cost savings from vaccination was sensitive to variations in the cost of varicella vaccine, the percentage of patients hospitalized for treatment with acyclovir, and the percentage of patients exposed to varicella infection. One- and two-way sensitivity analyses confirmed that vaccination was the dominant cost-effective strategy under all conditions examined. We conclude that vaccination for varicella pretransplant is cost-effective for patients with CRF, and that the magnitude of cost savings is sensitive to the cost of hospitalization, the percentage of patients exposed to varicella, and the cost of varicella vaccination. Pending results of ongoing studies of the safety and efficacy of VZV vaccine in children with CRF, we recommend that VZV vaccine be given to all children with CRF.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Varicella infection post‐renal Tx may cause severe complications, including allograft rejection, hepatitis, pneumonitis, or death (1–12). Transplant recipients exposed to varicella are generally treated with VZIG in an attempt to prevent actual infection (13–16).…”

mentioning

confidence: 99%

Pretransplant varicella vaccination is cost‐effective in pediatric renal transplantation

Olson

Shope

Flynn

2001

Pediatric Transplantation

View full text Add to dashboard Cite

show abstract

“…The VZV infection is usually secondary, but a small proportion may be primary (2). Adult-onset varicella infection reported in renal transplant recipients (1-7) can be fatal (4,7). Visceral involvement is common in the immunocompromised patient, and both hepatitis and brinolysis have been described in fatal cases (4,7,8).…”

mentioning

confidence: 99%

“…Adult-onset varicella infection reported in renal transplant recipients (1-7) can be fatal (4,7). Visceral involvement is common in the immunocompromised patient, and both hepatitis and brinolysis have been described in fatal cases (4,7,8). Although rare, there have been reports on hepatitis complicating varicella infection even in immunocompetent adults (9,10).…”

mentioning

confidence: 99%

Varicella Infection in a Renal Transplant Recipient Associated with Abdominal Pain, Hepatitis, and Glomerulonephritis

Os¹,

Strøm²,

Stenehjem³

et al. 2001

Scandinavian Journal of Urology and Nephrology

View full text Add to dashboard Cite

A 36-year-old renal transplant patient developed 9 years after a successful transplantation a fatal secondary varicella infection. The disseminated varicella infection was associated with hepatitis with liver necrosis, disseminated intravascular coagulation and fibrinolysis and glomerulonephritis. To our knowledge this is the first description of glomerulonephritis associated with varicella infection in a renal transplanted patient. The autopsy showed morphologically a mesangial glomerulonephritis with minor proliferative activity and extensive deposits by electronmicroscopy, mainly in the mesangium. The ongoing immunosuppression may have modified the mesangial cell response to the deposition of immune complexes.

show abstract

Disseminated Varicella Zoster Virus Infection in Adult Renal Transplant Recipients: Outcome and Risk Factors

Rommelaere

Maréchal

Yombi

et al. 2012

Transplantation Proceedings

View full text Add to dashboard Cite

Fatal varicella with primary fibrinolysis in a renal transplant recipient

Cited by 6 publications

References 3 publications

Pretransplant varicella vaccination is cost‐effective in pediatric renal transplantation

Pretransplant varicella vaccination is cost‐effective in pediatric renal transplantation

Varicella Infection in a Renal Transplant Recipient Associated with Abdominal Pain, Hepatitis, and Glomerulonephritis

Disseminated Varicella Zoster Virus Infection in Adult Renal Transplant Recipients: Outcome and Risk Factors

Contact Info

Product

Resources

About