Fatal swelling of the groin – Clear cell sarcoma: a rare but important differential diagnosis to malignant melanoma

Zaremba, Anne; Zimmer, Lisa; Chorti, Eleftheria; Reissig, Timm M.; Bauer, Sebastian; Podleska, Lars Erik; Schulz, Andrea; Hadaschik, Eva; Griewank, Klaus G.; Roesch, Alexander; Schadendorf, Dirk; Livingstone, Elisabeth

doi:10.1111/ddg.14204

Cited by 3 publications

(2 citation statements)

References 13 publications

(19 reference statements)

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“…However, in other reports, a tumor that lacks pigmentation clinically and has melanin pigmentation observed in the histopathological report is also included in this category [ 13 ]. Moreover, several literature findings highlight the challenges in the differential histopathological diagnosis of amelanotic melanoma and other diseases like oral scleritis [ 14 ], odontogenic neoplasm [ 15 ], clear cell sarcoma [ 16 ], and cases of oral sarcomas initially considered melanomas [ 17 ]. In our case, a differential diagnosis was made between amelanotic melanoma and a suspected leiomyosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Challenges in the Diagnosis and Treatment of Oral Amelanotic Malignant Melanoma: A Case Report

Rosu,

Tolea,

Parosanu

et al. 2024

Cureus

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Oral malignant melanoma (OMM) is extremely rare and usually has a poor prognosis. Early diagnosis is very important and can improve survival but it is usually difficult due to a lack of symptomatology. We present the first case of a 39-year-old East European woman with oral amelanotic melanoma, who underwent surgery and adjuvant immunotherapy; however, after six months, she developed local recurrence. The patient continued immunotherapy with external radiotherapy targeting the oral tumor recurrence. During therapy, imagistic reevaluation brought evidence of bones, lungs, liver, endotracheal, and brain metastases. Histological differential diagnosis between amelanotic OMM and leiomyosarcoma was necessary to establish the right course of treatment. A series of complications further delayed chemotherapy administration, making the treatment in this case very challenging. The patient had a significant, although late response to immunotherapy, and maintained a good performance status during disease progression with a survival of 15 months until present.

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Section: Discussionmentioning

confidence: 99%

Challenges in the Diagnosis and Treatment of Oral Amelanotic Malignant Melanoma: A Case Report

Rosu,

Tolea,

Parosanu

et al. 2024

Cureus

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“…The tumor can occur in any part of the body, with most cases occurring in the limbs, 40% in the foot and ankle [6] , followed by the knee, thigh, and hand [7] . There are only a few reports of CCS occurring in the groin [8][9][10][11][12] , and it is even rarer in children [8,12] .…”

Section: Discussionmentioning

confidence: 99%

NGS-Assisted Diagnosis of Clear Cell Sarcoma in the Inguinal Region of a Child: A Case Report

Zhang,

Cheng,

et al. 2023

Preprint

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Transparent cell sarcoma has an extremely low incidence rate, and children are not a high-risk age group. This study reported a case of recurrent tumor in the inguinal region of an 11-year-old boy. The pathological report of the puncture showed vascular epithelioid cell tumor. After treatment, the effect was not obvious. After surgical resection, NGS detection was performed on the gross specimen, and the EWSR1-ATF1 gene was found. Combined with the pathological features, the final diagnosis was CCS. This article emphasizes the importance of NGS in the auxiliary diagnosis of rare malignant tumors and the necessity of accurate diagnosis and treatment.

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Ipilimumab/nivolumab

2021

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Fatal swelling of the groin – Clear cell sarcoma: a rare but important differential diagnosis to malignant melanoma

Cited by 3 publications

References 13 publications

Challenges in the Diagnosis and Treatment of Oral Amelanotic Malignant Melanoma: A Case Report

Challenges in the Diagnosis and Treatment of Oral Amelanotic Malignant Melanoma: A Case Report

NGS-Assisted Diagnosis of Clear Cell Sarcoma in the Inguinal Region of a Child: A Case Report

Ipilimumab/nivolumab

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