Fatal spontaneous intraperitoneal hemorrhage in association with apixaban: A case report

Abstract

We present the case of an 80-year-old gentleman with a spontaneous intraperitoneal hemorrhage secondary to direct oral anticoagulant (DOAC) medication. As far as we are aware this is the third documented case of spontaneous intraperitoneal hemorrhage in association with direct oral anticoagulants (DOACs) therapy. Previously published cases have also cited apixaban as the associated DOAC. With their increasing prevalence, spontaneous intraperitoneal hemorrhage should be a recognized presentation for the patient in extremis on DOAC therapy.