Fatal Respiratory Syncytial Virus Infection in Severe Combined Immunodeficiency Syndrome

Miłner, Małgarzata; Hutchins, Grover M.

doi:10.1001/archpedi.1985.02140130049028

Cited by 22 publications

(13 citation statements)

References 13 publications

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“…RSV-infected children with prolonged viral shedding, severe disease, and giant cell pneumonia have not had isolated cell-mediated deficiencies, but have had severe combined immunodeficiency syndrome with deficits in both T cell and B cell functions (16,17). RSV-specific lymphocyte proliferation has been detected in normal children after RSV infection (18,19), but there is no clear correlation with age or severity ofdisease ( 18) and neither the phenotype nor the function of the proliferating cells was defined.…”

Section: Discussionmentioning

confidence: 99%

Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice.

Graham¹,

Bunton²,

Wright³

et al. 1991

J. Clin. Invest.

469

441

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The role of CD4+ and CD8+ T lymphocytes in terminating respiratory syncytial virus (RSV) replication, causing disease, and protecting from reinfection was investigated using a BALB/c mouse model in which CD4+ or CD8+ lymphocytes or both were depleted by injections of Mab directed against the respective mouse lymphocyte determinants. Kinetics of RSV replication, illness, and pathology were assessed after primary infection and rechallenge. Both CD4+ and CD8+ lymphocyte subsets were involved in terminating RSV replication after primary infection. When both T lymphocyte subsets were depleted RSV replication was markedly prolonged, yet no illness was evident, suggesting that host immune response rather than viral cytocidal effect was the primary determinant of disease in mice. Both CD4+ and CD8+ lymphocytes contributed to illness, although CD8+ lymphocytes appeared to play the dominant role in this particular system. Analysis of histological responses suggested that CD4+ lymphocytes were required for the appearance of peribronchovascular lymphocytic aggregates seen in normal mice after rechallenge, and that the presence of alveolar lymphocytes was correlated with illness. It is postulated that antibody is an illness-sparing mechanism for protecting mice from RSV infection, and that T lymphocytes are an important determinant of illness. Further delineation of RSVinduced immunopathogenesis in primary infection and reinfection will provide important information for the development of vaccine strategies. (J. Clin. Invest. 1991. 88:1026-1033

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Section: Discussionmentioning

confidence: 99%

Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice.

Graham¹,

Bunton²,

Wright³

et al. 1991

J. Clin. Invest.

469

441

View full text Add to dashboard Cite

show abstract

“…In infants with severely compromised immune function, for example, infected mononuclear cells could spread RS virus from the respiratory tract to other organs, such as kidney, liver, or myocardium [Fishaut et al, 1980;Milner et al, 1985].…”

Section: Discussionmentioning

confidence: 99%

Detection of respiratory syncytial virus RNA in blood of neonates by polymerase chain reaction

Rohwedder

Keminer

Förster³

et al. 1998

J. Med. Virol.

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During the winter season of 1994/1995, nasopharyngeal aspirates and blood samples of neonates who were admitted to the Neonatal Intensive Care Unit (NICU) (group 1) and infants with respiratory tract disease (group 2) were examined prospectively for the presence of respiratory syncytial virus (RSV). Examination of nasal washes were done by antigen detection and blood samples were tested by nested reverse transcription and polymerase chain reaction (RT-PCR). The results of the 41 neonates studied were as follows: 14/41 were positive for RSV antigen in nasal washes and for RSV-RNA in blood, 5/41 were only RSV antigen positive, 13/41 neonates had negative nasal washes; 6 had positive RT-PCR results in blood. In 9/41 cases only blood samples were available. Five of these were positive by RT-PCR testing. Group 2 included 20 infants hospitalized with respiratory tract disease, e.g., pneumonia, bronchiolitis, or Upper Respiratory Tract Infection (URTI). Eleven out of twenty were positive for RSV antigen in nasal washes and 6/20 were also positive for RSV-RNA in blood. The conclusion is that viremia may be a frequent occurrence in neonates and young children.

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“…In urban areas of Britain 2.5% of babies required hospitalisation with RS virus infection [23]. Older children and adults are regularly reinfected but adults generally experience milder illness, although severe LRTI may occur in the elderly, chronically ill, or immunocompromised [10,13].…”

Section: Introductionmentioning

confidence: 99%

Epitope specificities of human serum antibodies reactive with respiratory syncytial virus fusion protein

Robinson

Everson

1992

Archives of Virology

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Respiratory syncytial (RS) virus continues to cause serious human respiratory disease and no prophylactic vaccine is yet available. Serum antibodies to RS virus fusion protein (F) that have the appropriate specificities and activities could confer protection against severe RS virus infections. To explore human serum antibody responses to RS virus F we first characterised four epitopes on F and then measured the concentrations of human serum antibodies to these sites for 389 sera. Individuals varied in serum antibody concentration to the epitopes. The distribution patterns of the concentrations of antibodies reactive to each epitope were different. Antigenic variation of F at these epitopes in Southampton RS virus isolates was examined by immunofluorescence. The F proteins from different isolates varied within and between RS virus subtypes which co-circulated in the outbreak of winter 1985-1986. Variations in F detected by immunofluorescence were consistent with differences between the strains' susceptibilities to monoclonal antibody antiviral action.

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Fatal Respiratory Syncytial Virus Infection in Severe Combined Immunodeficiency Syndrome

Cited by 22 publications

References 13 publications

Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice.

Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice.

Detection of respiratory syncytial virus RNA in blood of neonates by polymerase chain reaction

Epitope specificities of human serum antibodies reactive with respiratory syncytial virus fusion protein

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