Fatal pulmonary toxicity occurring within two weeks of initiation of amiodarone

Kharabsheh, Suleiman; Abendroth, Catherine; Kozak, Mark

doi:10.1016/s0002-9149(02)02213-0

Cited by 46 publications

(23 citation statements)

References 18 publications

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“…Adult respiratory distress syndrome developed in some patients undergoing invasive procedures and fatal pulmonary toxicity has been reported as early as 2 wk of therapy. 9 Almost all, patients receiving amiodarone appear to show the so-called ''amiodarone effect,'' defined as the mere presence of foamy cells. On the other hand, amiodarone toxicity is a constellation of clinical, radiologic, and histologic findings secondary to tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Amiodarone lung toxicity in a cardiac transplant candidate initially diagnosed by fine‐needle aspiration: Cytologic, histologic, and electronmicroscopic findings

Ömeroğlu

Kalugina

Erşahin

et al. 2006

Diagnostic Cytopathology

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A cardiac transplant candidate with ischemic cardiomyopathy developed bilateral small parenchymal opacities in lower lobes of the lung. A fine-needle aspiration (FNA) was performed that revealed changes characteristic of amiodarone toxicity. Subsequently performed lung biopsies and electron microscopic studies confirmed the initial FNA diagnosis. The patient has been successfully transplanted with marked improvement in his clinical findings. This is the first case of amiodarone lung toxicity where the diagnosis was initially suggested based on the FNA findings. We also describe the clinical, cytological, histological, and electron microscopic (EM) findings of amiodarone-related pulmonary toxicity and provide a review of the literature.

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Section: Discussionmentioning

confidence: 99%

Amiodarone lung toxicity in a cardiac transplant candidate initially diagnosed by fine‐needle aspiration: Cytologic, histologic, and electronmicroscopic findings

Ömeroğlu

Kalugina

Erşahin

et al. 2006

Diagnostic Cytopathology

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“…Acute APT is an unusual pattern of lung response to amiodarone [17, 35, 36, 37, 38]. Acute APT may occur within a few days after a loading dose of intravenous amiodarone, or later at almost any time into treatment.…”

Section: Clinical Patterns Of Di-ildmentioning

confidence: 99%

Interstitial Lung Disease Induced by Drugs and Radiation

Camus¹,

Fanton²,

Bonniaud³

et al. 2004

Respiration

352

273

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An ever-increasing number of drugs can reproduce variegated patterns of naturally occurring interstitial lung disease (ILD), including most forms of interstitial pneumonias, alveolar involvement and, rarely, vasculitis. Drugs in one therapeutic class may collectively produce the same pattern of involvement. A few drugs can produce more than one pattern of ILD. The diagnosis of drug-induced ILD (DI-ILD) essentially rests on the temporal association between exposure to the drug and the development of pulmonary infiltrates. The histopathological features of DI-ILD are generally consistent, rather than suggestive or specific to the drug etiology. Thus, the diagnosis of DI-ILD is mainly made by the meticulous exclusion of all other possible causes. Drug dechallenge produces measurable improvement in symptoms and imaging in the majority of patients, whereas corticosteroid therapy is indicated if symptoms are present or drug dechallenge is without an effect. Rechallenge is justified in a minority of patients, and is discouraged for diagnostic purposes only. Pneumotox^® (www.pneumotox.com) provides updated information on drug-induced respiratory disease.

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“…Most side effects can therefore be expected to occur after weeks of oral treatment, although rare cases of acute pulmonary toxicity have been reported [39,40].…”

Section: Side Effects Of Intravenous Amiodaronementioning

confidence: 99%