Fatal Pulmonary Mucormycosis due to Rhizopus homothallicus

Compain, Fabrice; Aït-Ammar, Nawel; Botterel, Françoise; Gibault, Laure; Pimpec-Barthes, Françoise Le; Dannaoui, Éric

doi:10.1007/s11046-017-0151-7

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…R. homothallicus was isolated from patients with ROCM type, pulmonary and cutaneous form of disease [5,143,144]. A single case of fatal pulmonary infection due to R. homothallicus was reported from France [145]. Infections due to uncommon Mucorales such as Cokeromyces recurvatus , Syncephalastrum species, and Saksenaea species are rarely reported [4,139].…”

Section: Causative Agents Of Mucormycosismentioning

confidence: 99%

Global Epidemiology of Mucormycosis

Prakash

Chakrabarti

2019

JoF

700

753

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Mucormycosis is an angio-invasive fungal infection, associated with high morbidity and mortality. A change in the epidemiology of mucormycosis has been observed in recent years with the rise in incidence, new causative agents and susceptible population. The rise has been perceived globally, but it is very high in the Asian continent. Though diabetes mellitus overshadow all other risk factors in Asia, post-tuberculosis and chronic renal failure have emerged as new risk groups. The rhino-cerebral form of mucormycosis is most commonly seen in patients with diabetes mellitus, whereas, pulmonary mucormycosis in patients with haematological malignancy and transplant recipients. In immunocompetent hosts, cutaneous mucormycosis is commonly seen following trauma. The intriguing clinical entity, isolated renal mucormycosis in immunocompetent patients is only reported from China and India. A new clinical entity, indolent mucormycosis in nasal sinuses, is recently recognized. The causative agents of mucormycosis vary across different geographic locations. Though Rhizopus arrhizus is the most common agent isolated worldwide, Apophysomyces variabilis is predominant in Asia and Lichtheimia species in Europe. The new causative agents, Rhizopus homothallicus, Mucor irregularis, and Thamnostylum lucknowense are reported from Asia. In conclusion, with the change in epidemiology of mucormycosis country-wise studies are warranted to estimate disease burden in different risk groups, analyse the clinical disease pattern and identify the new etiological agents.

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Section: Causative Agents Of Mucormycosismentioning

confidence: 99%

Global Epidemiology of Mucormycosis

Prakash

Chakrabarti

2019

JoF

700

753

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“…MK351861 was isolated from soil at Ratapani wildlife sanctuary in Raisen, Madhya Pradesh [ 18 ]. Sequence KU926333 was isolated from the lung biopsy sample of a fatal case of pulmonary mucormycosis in a patient with unchecked diabetes mellitus from Paris [ 19 ]. Genomic identification of the fungi is strongly recommended for improved epidemiological understanding of mucormycosis.…”

Section: Discussionmentioning

confidence: 99%

Rhizopus homothallicus, an emerging pathogen causing cavitary lung lesions

Taneja

Chatterjee

Sachdeva

et al. 2023

Access Microbiology

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Introduction. Rhizopus homothallicus is an emerging pathogen that causes pulmonary mucormycosis. Case Presentation. We report a case of pneumonia caused by R. homothallicus in a 54-year-old type 2 diabetic patient. The organism was isolated from bronchoalveolar lavage fluid and preliminarily identified by fungal morphology and finally by sequencing of the internal transcribed spacer region. Conclusion. Mucormycosis may be associated with cavitary lung lesions against a backdrop of poorly controlled diabetes or other immunosuppressed states. Pulmonary mucormycosis may have variable clinical and radiological presentations. Therefore, strong clinical suspicion and prompt management can address the high fatality associated with the disease.

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“…Isolation of such a rare pathogen led us to do an extensive and systematic search for any published cases of mucormycosis caused by this species. We found 8 cases published in 5 articles (Table 2) [13][14][15][16][17]. Of these 8 cases, only 2 had rhino-orbital-cerebral mucormycosis (ROCM), 5 had pulmonary and 1 had cutaneous mucormycosis.…”

Section: Discussionmentioning

confidence: 99%

Rhizopus homothallicusrhino‐orbital‐cerebral mucormycosis: Six cases from a tertiary care Centre, North India

Chakravarty

Gupta

Siva

et al. 2022

Tropical Med Int Health

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Objective: To report six cases of Rhizopus homothallicus rhino-orbital-cerebral mucormycosis in North India between April 2021 and July 2021. Case Details: All six patients had diabetes, concomitant SARS-CoV-2 infection, a history of oxygen requirement and steroid intake. Among these six cases 4 were female. All patients presented with sinus pain and peri-orbital swelling. COVID-19-associated mucormycosis (CAM) was diagnosed based on microbiological examination of the biopsied tissue, and its staging was determined radiologically by CT and MRI. Three patients were in stage III-C, the others were in stage II-C, II-D and IV-A. A multidisciplinary team treated the patients with extensive surgical debridement of the affected tissue, correction of predisposing comorbidities and administration of an antifungal agents. Patients were followed up for 6 months with routine direct nasal endoscopy to check the sinonasal cavity for any recurrence. All the six patients survived at 6 months of follow-up. Conclusion: A timely initiated multidisciplinary team-based approach can reduce the mortality in rhino-orbital-cerebral mucormycosis cases caused by R. homothallicus.

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Fatal Pulmonary Mucormycosis due to Rhizopus homothallicus

Cited by 9 publications

References 36 publications

Global Epidemiology of Mucormycosis

Global Epidemiology of Mucormycosis

Rhizopus homothallicus, an emerging pathogen causing cavitary lung lesions

Rhizopus homothallicusrhino‐orbital‐cerebral mucormycosis: Six cases from a tertiary care Centre, North India

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