Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-β1 and cyclooxygenase-2

Shen, Ying‐Chun; Chiu, Chang‐Fang; Chow, Kuan‐Chih; Chen, C. L.; Liaw, Y. C.; Yeh, Shih-Peng

doi:10.1038/sj.bmt.1704616

Cited by 17 publications

(6 citation statements)

References 24 publications

(17 reference statements)

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“…Previous data indicate that IGF-I is elevated in human fibrotic lung diseases and in animal models of pulmonary fibrosis (6-12, 14-15, 41). In addition, recent studies have found a correlation between IGF-I staining and CD68positive cells, and lung fibroblasts, suggesting alveolar macrophages are a major source ofthe IGF-I molecules present in the lung (32,37,43).…”

Section: Discussionmentioning

confidence: 97%

Increased Levels of IGF-1 and Beta2-Microglobulin in Epithelial Lining Fluid of Preterm Newborns Developing Chronic Lung Disease: Effects of rhG-CSF

Capoluongo

Vento

Ameglio³

et al. 2006

Int J Immunopathol Pharmacol

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Insulin-like growth factor-I (IGF-I) is involved in regulating the TH-lITH-2 balance, favoring the development of the TH-2 compartment which enhances fibrosis, one of the main characteristics of Chronic Lung Disease (CLD) in premature newborns. Limited data is available concerning a possible association between early epithelial lining fluid (ELF) concentrations ofIGF-I (total and free forms), IGF-binding protein-3 (IGFBP-3), b2-microglobulin (B2M) and subsequent development of CLD in preterm neonates. If neutropenic, preterm neonates are frequently treated with recombinant human Granulocyte Colony Stimulating Factor (rhG-CSF). The objective of the study was to correlate ELF concentrations of IGF-I and B2M during the first week of life both in non-neutropenic and in rhG-CSF-treated neutropenic preterm neonates, with subsequent development in CLD. Thirty preterm neonates with Respiratory Distress Syndrome (6 with neutropenia) were studied. Eleven out of 24 non-neutropenic preterm infants (46%) and all of the six neutropenic subjects (IOOo/~) developed CLD. With the exception of first day values, there was a clear similarity in the behaviors of assayed molecules between non-neutropenic and neutropenic patients developing CLD. Non-neutropenic patients without CLD showed significantly lower values of free IGF-I and B2M both on days 1 and 3. Total IGF-I and cell counts were different only on the 3rd day. Conclusions: I) the mechanisms leading to CLD might be mediated by high levels of IGF-family molecules soon after birth 2) B2M could be a marker of increased bronchoalveolar lavage fluid cellularity with potential inflammatory properties 3) G-CSF treatment induces an increased synthesis of IGF-I moleculesby cells recruited in the lung, with possible enhancement of the fibrogenic mechanisms. Chronic lung disease (CLD) in very low birth weight infants is a major health concern facing neonatologists because of its morbidity and high mortality risk (1-2). The pathogenesis of CLD is still unclear, although several risk factors have been described (3-6). Great importance has recently been attributedto pulmonary inflammation(1-3) and several pro-inflammatory and anti-inflammatory/fibrogenic cytokines in bronchoalveolar lavage fluid (BALF) have been indicated as possible triggers of pulmonary fibrosis (1-3, 5), one of the main characteristics of CLD (I). In adult lung fibrosis, an

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Section: Discussionmentioning

confidence: 97%

Increased Levels of IGF-1 and Beta2-Microglobulin in Epithelial Lining Fluid of Preterm Newborns Developing Chronic Lung Disease: Effects of rhG-CSF

Capoluongo

Vento

Ameglio³

et al. 2006

Int J Immunopathol Pharmacol

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“…Also similar to brentuximab, patients with bleomycin and gemcitabine-induced pulmonary toxicity typically present with nonspecific subacute clinical syndromes, for example, dyspnea, cough, fever, and fatigue; thus a high index of suspicion is needed when the diagnosis remains elusive after an extensive workup [ 8 , 9 ]. In contrast, the diagnosis of carmustine lung toxicity is supported by a lung biopsy which typically shows interstitial fibrosis with edema and hyaline membrane formation [ 10 ]. Treatment for this particular patient was mostly supportive with the use of oxygen and nebulizers; interestingly, some reports have shown that steroids are the most effective treatment [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Severe Acute Pulmonary Toxicity Associated with Brentuximab in a Patient with Refractory Hodgkin’s Lymphoma

Sabet

Ramírez

Cespedes

et al. 2016

Case Reports in Pulmonology

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Acute pulmonary toxicity associated with brentuximab appears to be a rare but serious adverse effect that can be potentially fatal. We report the case of a twenty-nine-year-old female with Hodgkin's lymphoma who was treated with brentuximab and later presented with severe acute pulmonary toxicity; she improved after the discontinuation of brentuximab and administration of antibiotics and glucocorticoid therapy. Currently there is very little data in the literature in regard to the clinical manifestations and characteristics of patients taking brentuximab and the potential development of acute severe pulmonary toxicity, as well as the appropriate therapeutic approach, making this particular case of successful treatment and resolution unique.

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“…Pulmonary fibrosis, the development of connective tissue in the lung is connected to IGF by its fibroblast‐proliferation stimulating effects.…”

Section: Prominent Genes Affected By Icariin and Linked To Geriatric mentioning

confidence: 99%

Plant polyphenols in the treatment of age‐associated diseases: Revealing the pleiotropic effects of icariin by network analysis

Schluesener

2013

Molecular Nutrition Food Res

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Polyphenols are a broad class of compounds. Some are ingested in substantial quantities from nutritional sources, more are produced by medicinal plants, and some of them are taken as drugs. It is becoming clear, that a single polyphenol is impacting several cellular pathways. Thus, a network approach is becoming feasible, describing the interaction of a single polyphenol with cellular networks. Here we have selected icariin to draw a prototypic network of icariin activities. Icariin appears to be a promising drug to treat major age-related diseases, like neurodegeneration, memory and depressive disorders, chronic inflammation, diabetes, and osteoporosis. It interacts with several relevant pathways, like PDE, TGF-ß, MAPK, PPAR, NOS, IGF, Sirtuin, and others. Such networks will be useful to future comparative studies of complex effects of polyphenols.

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Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-β1 and cyclooxygenase-2

Cited by 17 publications

References 24 publications

Increased Levels of IGF-1 and Beta2-Microglobulin in Epithelial Lining Fluid of Preterm Newborns Developing Chronic Lung Disease: Effects of rhG-CSF

Increased Levels of IGF-1 and Beta2-Microglobulin in Epithelial Lining Fluid of Preterm Newborns Developing Chronic Lung Disease: Effects of rhG-CSF

Severe Acute Pulmonary Toxicity Associated with Brentuximab in a Patient with Refractory Hodgkin’s Lymphoma

Plant polyphenols in the treatment of age‐associated diseases: Revealing the pleiotropic effects of icariin by network analysis

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