Fatal Pulmonary Embolism in 100 Battle Casualties

Tr, Hamilton; Dm, Angevine

doi:10.1093/milmed/99.5.450

Cited by 8 publications

(4 citation statements)

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“…In contrast to the latter age group an incidence of fatal embolism has been reported in 6 per cent. of young battle casualties (Hamilton and Angevine, 1946).…”

Section: General Pathologymentioning

confidence: 99%

The formation of a platelet adhesive factor by disruption of the creatine phosphokinase molecule

Martin¹

1976

The Journal of Pathology

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It was discovered that the product of a mix containing the enzyme creatine phosphokinase (CPK) and either glutathione (GSH) or cysteine caused platelets to adhere together in vitro. This platelet adhesive factor (PAF) was formed as CPK enzyme activity declined. An alternative method for the destruction of enzyme activity--heat at 56 degrees C--also resulted in the formation of an in-vitro active PAF which was both less stable and active than its chemically produced counterpart. Assay of the platelet adhesive potency of the CPK-GSH mix, using human platelets, revealed a wide variation in the response of different individuals' platelets to standard quantities of PAF. The nature of this preparation of PAF was investigated by both biochemical and biophysical means, including ion exchange chromatography, electrophoresis, amino acid analysis and analytical ultracentrifuge studies. Evidence is presented that PAF is the product of the disruption of the dimeric structure of the CPK molecule. PAF was found to adhere to paper, under the conditions of electrophoresis imposed, and also to cause sephadex beads to bind together, characteristics which suggested that the platelet adhesion reaction was probably a biophysical process. Red and white cells were not similarly affected. The feasibility of this novel concept for the initiation of platelet adhesion, as a naturally occurring process, was supported by the results of animal experiments in which a statistically depression of platelets in the systemic circulation followed the intravascular administration of PAF. The possible relevance to man of this basic mechanism in relation to exercise and disease processes, including ideopathic and post-traumatic thrombosis, atherogenesis, and dysbaric aseptic necrosis of bone, is discussed.

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“…In contrast to the latter age group an incidence of fatal embolism has been reported in 6 per cent. of young battle casualties (Hamilton and Angevine, 1946).…”

Section: General Pathologymentioning

confidence: 99%

The formation of a platelet adhesive factor by disruption of the creatine phosphokinase molecule

Martin¹

1976

The Journal of Pathology

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show abstract

“…39 The fulfillment of this mission necessitated official travel by laboratory personnel to Army installations in all nine service commands. Since there was no precedent regarding the organization of an installation of this type as a military establishment, considerable difficulty was experienced in determining its status.…”

Section: Mission and Statusmentioning

confidence: 99%

“…39 Classes for instruction of officers and enlisted men were enlarged and increased in number. The production of biologic products for diagnostic, prophylactic, and therapeutic use by the Army, the Navy, and Government bureaus was expanded.…”

Section: Expansion During World War Imentioning

confidence: 99%

Preventive Medicine in World War II, Volume 9, Special Fields

Scott¹,

Anderson²

1972

The Journal of Parasitology

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“…Before prophylaxis, embolism was particularly common '(46-60%) in elderly subjects dying with a fractured femur or tibia, was frequent in those with a fractured pelvis (27 %) or spine (14 %), but less common in other subjects. Even young battle casualties have a not inconsiderable risk, as fatal embolism was found in 62 % of over 1,000 such subjects, mostly in those with lower limb injuries (Hamilton and Angevine, 1946).…”

Section: Pulmonary Embolismmentioning

confidence: 99%

Thrombosis and embolism after injury.

Sevitt¹

1970

Journal of Clinical Pathology

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Fatal Pulmonary Embolism in 100 Battle Casualties

Cited by 8 publications

References 0 publications

The formation of a platelet adhesive factor by disruption of the creatine phosphokinase molecule

The formation of a platelet adhesive factor by disruption of the creatine phosphokinase molecule

Preventive Medicine in World War II, Volume 9, Special Fields

Thrombosis and embolism after injury.

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