Fatal Poisoning with Methyprylon (Noludar), a Nonbarbiturate Sedative

Reidt, William U.

doi:10.1056/nejm195608022550507

Cited by 24 publications

(2 citation statements)

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“…of methyprylon. 50 The clinical picture of methyprylon intoxication resembles that seen after barbiturate overdosage. 45 ,50 Some believe the drug has a wider margin of safety than the barbiturates.…”

Section: Methyprylon Inoludarlmentioning

confidence: 99%

Addiction to nonbarbiturate sedative and tranquilizing drugs

Essig¹

1964

Clin Pharma and Therapeutics

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Increasing numbers of nonbarbiturate sedative drugs are being introduced into medical practice. Despite their nonbarbiturate chemical structure and regardless of designations other than "sedative-hypnotic," at least six of the newer depressant drugs can cause states of intoxication and physical dependence that are clinically similar to those induced by barbiturates. These drugs are meprobamate (Miltown, Equanil) , glutethimide (Doriden), ethinamate (Valmid), ethchlorvynol (Placidyl), methyprylon (Noludar), and chlordiazepoxide (Librium). The behavioral effects of these drugs and their combination with ethanol may become an increasingly important public hazard. The abstinence syndromes that can result from the abrupt withdrawal of excess dosages of these drugs include convulsions and psychotic behavior. Death has been attributed to withdrawal of meprobamate and methyprylon. Office or ambulatory withdrawal of any of these drugs after use in large dosageis not recommended. Gradual dosage reduction or barbiturate substitution prior to its gradual withdrawal during hospitalization is suggested. Substitution of diphenylhydantoin (Dilantin) or any of the phenothiazines as the sole means of support during sedative-hypnotic drug withdrawal is a questionable practice.

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Section: Methyprylon Inoludarlmentioning

confidence: 99%

Addiction to nonbarbiturate sedative and tranquilizing drugs

Essig¹

1964

Clin Pharma and Therapeutics

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“…That a similar situation can arise with the newer agents is exemplified by a fatal case of poisoning with methyprylon. 155 Hypnotics amI sedatives 323…”

Section: Clinical Pharmacologymentioning

confidence: 99%

Clinical pharmacology of hypnotics and sedatives

Shideman

1961

Clin Pharma and Therapeutics

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If there is any tendency to become complacent about the adequacy of knowledge in a given area, a review of the subject usually serves to dispel this attitude. Although there exists a formidable body of knowledge on the pharmacology of the hypnotics and sedatives, that which remains unknown is even more formidable. Many of the experiments which have yielded information on the pharmacodynamics and disposition of these drugs in laboratory animals do not have their counterparts in human studies. In such instances, only a logical guess can be made in an effort to bridge this gap. The known effects of the barbiturates, bromides, paraldehyde, chloral hydrate, and newer hypnotics and sedatives in man are presented and an attempt is made to compare these with findings in other species. Where data of a critical nature with respect to the human pharmacology of these drugs are lacking, the fundamental features of their actions on other animals are presented. In addition to the more classic aspects of their pharmacodynamics, the more significant alterations in behavior produced by these agents are summarized. Studies dealing with their pharmacology in both the normal and pathologic states and in therapeutic and toxic dosages are outlined. Finally, the disposition of these compounds in the body is considered, inasmuch as this aspect of their pharmacology may have important bearing on the responses elicited by them in the organism.

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Addiction to Methyprylon

Berger¹

1961

JAMA

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Fatal Poisoning with Methyprylon (Noludar), a Nonbarbiturate Sedative

Cited by 24 publications

References 0 publications

Addiction to nonbarbiturate sedative and tranquilizing drugs

Addiction to nonbarbiturate sedative and tranquilizing drugs

Clinical pharmacology of hypnotics and sedatives

Addiction to Methyprylon

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