Fatal poisoning by ingestion of Taxus Baccata leaves

Pilija, Vladimir; Djurendic-Brenesel, Maja; Miletic, Stevan

doi:10.1016/j.forsciint.2018.07.017

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…Our pooled overall results on accuracy (92.8%; 95% CI 91.0–94.6%) outperformed all previous studies that presented pooled data 2 , 13 , 17 , 22 , 23 . Both sensitivity and specificity pooled results also surpassed most previous European studies 2 , 22 , 23 except for Cameriere et al 13 (98%) and De Luca et al 17 (95.7%; 95% CI 92.1–98.0%). The estimated post-test probability of the pooled data (95.6%; 95% CI 94.1–97.0%) showed similar results with previous studies.…”

Section: Discussionsupporting

confidence: 52%

Validation of the Third Molar Maturation Index (I3M) to assess the legal adult age in the Portuguese population

Neves¹,

Antunes‐Ferreira

Machado³

et al. 2020

Sci Rep

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Age estimation is a major step in forensic and legal procedures. Its relevance has been increasing due to growing society issues, such as identification of missing people, crimes against minors or lack of valid identification papers from locals or foreigners. Evaluation of the cut-off value of the Third Molar Maturation Index (I3M) = 0.08 for discriminating minors from adults in the Portuguese population. The left lower third molars were analysed by applying a specific cut-off value of 0.08 determined by Cameriere et al. in 2008. A sample of 778 digital panoramic radiographs of a representative Portuguese sample (442 females and 336 males), in the age range of 12–24 years (mean age 17.7 ± 2.98 years in females and 18.1 ± 3.0 years in males), was retrospectively evaluated. I3M decreased as the real age gradually increased in both sexes. The 0.08 cut-off score was valuable in discriminating adults from minors. According to the pooled results, the accuracy, by means of area under the curve, was 92.8% (95% confidence interval (CI) 91.0–94.6%). The proportion of correctly classified subjects (sensitivity) was 90.7% (95% CI 88.7–92.8%) and the specificity was 94.9% (95% CI 93.3–96.4%). The results show that I3M is a valuable method to differentiate minors from adults in the Portuguese population.

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Section: Discussionsupporting

confidence: 52%

Validation of the Third Molar Maturation Index (I3M) to assess the legal adult age in the Portuguese population

Neves¹,

Antunes‐Ferreira

Machado³

et al. 2020

Sci Rep

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“…Considering the history, circumstances, and autopsy findings as a whole, death was attributed to toxic ingestion of Taxus baccata -the English yew. Lethal consumption of T. baccata is recognized within academic literature to be associated with toxic ingestions, both accidental and intentional [5,7,9,11,[14][15][16][17][18][19][20][21][22][23][24][25][26][27]. The possibility for homicidal intent exists as a genuine risk [5,11,24].…”

Section: Discussionmentioning

confidence: 99%

“…Lethal consumption of T. baccata is recognized within academic literature to be associated with toxic ingestions, both accidental and intentional [5,7,9,11,[14][15][16][17][18][19][20][21][22][23][24][25][26][27]. The possibility for homicidal intent exists as a genuine risk [5,11,24].…”

Section: Discussionmentioning

confidence: 99%

“…In one study of 40 toxic ingestions of T. baccata, 75% of the 16 autopsied individuals were reported to show non-specific pulmonary edema [28]. Other reported autopsy findings include generalized venous congestion of major organs including the lungs [10,11,15,17,24,26], necrosis of the mucosa of the stomach or small intestines, and cerebral edema [5,24].…”

Section: Discussionmentioning

confidence: 99%

“…Gas‐chromatography has also been used, principally to measure 3,5‐Dimethoxyphenol (3,5‐DMP) as a marker of T . baccata ingestion [9–11]. The main advantages of the LC‐MS/MS technique are the high specificity and sensitivity of the method as well as the simultaneous analysis of various alkaloids present in T .…”

Section: Introductionmentioning

confidence: 99%

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Fatal ingestion ofTaxus baccata: English yew

Brooks-Lim

Mérette²,

Hawkins

et al. 2021

Journal of Forensic Sciences

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Poisoning from consumption of foraged alternative medicine products is an uncommon yet recognized occurrence. Here, presented is the case of a 40-year-old woman who was witnessed to collapse with labored breathing and subsequently died despite emergency medical personnel attendance and resuscitation efforts. Autopsy revealed the presence of plant matter that was visually identified as leaves from Taxus baccata -the English Yew. Isolation of alkaloids from the plant material and subsequent identification of the same alkaloids in the decedent's blood by liquid chromatographytandem mass spectrometry indicated a toxicological cause of death. This case illustrates a collaborative team approach among subject matter experts to unexpectedly discover and then confirm the sudden death of this woman from T. baccata toxicity.

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Mining pharmacotherapy utility from chemodiversity/biodiversity of Taxus plants

Hao

2021

Taxaceae and Cephalotaxaceae

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Fatal poisoning by ingestion of Taxus Baccata leaves

Cited by 6 publications

References 19 publications

Validation of the Third Molar Maturation Index (I3M) to assess the legal adult age in the Portuguese population

Validation of the Third Molar Maturation Index (I3M) to assess the legal adult age in the Portuguese population

Fatal ingestion ofTaxus baccata: English yew

Mining pharmacotherapy utility from chemodiversity/biodiversity of Taxus plants

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