Fatal pneumococcal septicaemia in coeliac disease

O'Donoghue, D.J.

doi:10.1136/pgmj.62.725.229

Cited by 27 publications

(12 citation statements)

References 4 publications

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“…This risk increase cannot be explained by potential confounding factors such as concomitant DM or socioeconomic factors. Our findings are therefore consistent with earlier case reports of coeliac disease and severe infection17 – 19 as well as with the increased risk of death from sepsis reported by Peters et al 4 (standardised mortality ratio = 7.1, 95% CI = 1.9 to 18.2). Using inpatient reference individuals, we found a 1.6-fold increased risk of subsequent sepsis in coeliac disease.…”

Section: Discussionsupporting

confidence: 93%

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Coeliac disease and risk of sepsis

Ludvigsson

Olén

Bell

et al. 2008

Gut

111

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Section: Discussionsupporting

confidence: 93%

“…With the exception of one mortality study (showing a 7-fold increased risk of death from sepsis4 among individuals with coeliac disease), we know of only case reports of severe infection in coeliac disease 17 – 19. In the mortality study, data on sepsis were limited to information from death certificates 4.…”

mentioning

confidence: 99%

Coeliac disease and risk of sepsis

Ludvigsson

Olén

Bell

et al. 2008

Gut

111

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“…Several case reports of severe and even fatal bacterial infections in such patients have, however, been published. [117][118][119] Cavitating lesions in mesenteric lymph nodes and the lungs have also been reported in patients with CD and hyposplenism and can be associated with significant mortality, presumably due to an overwhelming infection. [120][121][122][123] The etiology of these cavitating lesions is unknown but some authors have suggested that immune complexes result in endothelial damage leading to intranodal hemorrhagic necrosis.…”

Section: Splenic Dysfunctionmentioning

confidence: 99%

Hematologic manifestations of celiac disease

Halfdanarson¹,

Litzow²,

Murray

2006

Blood

320

281

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Celiac disease is a common systemic disorder that can have multiple hematologic manifestations. Patients with celiac disease may present to hematologists for evaluation of various hematologic problems prior to receiving a diagnosis of celiac disease. Anemia secondary to malabsorption of iron, folic acid, and/or vitamin B12 is a common complication of celiac disease and many patients have anemia at the time of diagnosis. Celiac disease may also be associated with thrombocytosis, thrombocytopenia, leukopenia, venous thromboembolism, hyposplenism, and IgA deficiency. Patients with celiac disease are at increased risk of being diagnosed with lymphoma, especially of the T-cell type. The risk is highest for enteropathy-type T-cell lymphoma (ETL) and B-cell lymphoma of the gut, but extraintestinal lymphomas can also be seen. ETL is an aggressive disease with poor prognosis, but strict adherence to a gluten-free diet may prevent its occurrence.

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“…25,[67][68][69] The increased mortality from tuberculosis and septicemia was consistent with earlier reports of severe infections in patients with celiac disease. [70][71][72] Splenic atrophy and/or hyposplenism occurs frequently in patients with celiac disease 37,73,74 and may predispose the patient to pneumonia and possibly other serious infections.…”

Section: Commentmentioning

confidence: 99%