Fatal outcome of herpes simplex virus type 1-induced necrotic hepatitis in a neonate

Meerbach, Astrid; Sauerbrei, Andreas; Meerbach, W; Bittrich, Hans-Jörg; Wutzler, Peter

doi:10.1007/s00430-005-0009-3

Cited by 20 publications

(14 citation statements)

References 22 publications

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“…The diagnosis of HSV‐related hepatitis is difficult because of the lack of clinical suspicion. It has been reported in immunocompromised hosts, such as pregnant women, neonates, patients on chemotherapy or corticosteroids, and patients infected with HIV (5–7).…”

Section: Discussionmentioning

confidence: 99%

Fulminant hepatitis from herpes simplex virus type 2 in an immunocompetent adult

Abbo

Alcaide

Pano

et al. 2007

Transplant Infectious Dis

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Herpes simplex virus (HSV) is regarded as a common viral pathogen that produces a wide variety of diseases. After a primary infection, which usually occurs during childhood and may or may not be clinically evident, the virus establishes a latent infection in the local sensory ganglia and can reactivate throughout the life of the individual. Fulminant hepatic failure (FHF) due to HSV infection is a clinical condition well known in pediatric, immunocompromised, and pregnant patients. It is rare in immunocompetent hosts. We report the case of a 51-year-old man with no significant past medical history who developed FHF with disseminated intravascular coagulopathy and septic shock secondary to HSV infection. The initial diagnosis was made through a frozen section of a needle liver biopsy and the presence of HSV was confirmed in the permanent section with immunohistochemistry. HSV was grown in cell culture from liver tissue obtained through an autopsy.

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Section: Discussionmentioning

confidence: 99%

Fulminant hepatitis from herpes simplex virus type 2 in an immunocompetent adult

Abbo

Alcaide

Pano

et al. 2007

Transplant Infectious Dis

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“…Most guidelines propose caesarean section for women developing a primary clinical infection within the last 4–6 weeks of gestation, because they cannot complete their seroconversion prior to the time of delivery, and therefore they could infect the neonates. When vaginal delivery is irreversible, since the risk of vertical transmission is high (41%), a maternal and neonatal intravenous acyclovir therapy is recommended [37–39]. …”

Section: Management Of First Infection With Hsv In Pregnancymentioning

confidence: 99%

Herpes Simplex Virus Infection in Pregnancy

Straface

Selmin

Zanardo

et al. 2012

Infectious Diseases in Obstetrics and Gynecology

122

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Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases. The purpose of this paper is to provide recommendations on management of herpes simplex infections in pregnancy and strategies to prevent transmission from mother to fetus.

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“…A number of case reports in the literature have also described acute liver failure in neonatal HSV. 9,10 Unlike the case reported here, HSV was not considered when the children first presented with a sepsis-like illness. Consequently, early treatment could not be given and the patients deteriorated still further resulting in either liver transplantation or death.…”

Section: Discussionmentioning

confidence: 59%