Fatal nifedipine ingestions in children

Lee, David C; Greene, Tucker; Dougherty, Timothy; Pearigen, Paul D.

doi:10.1016/s0736-4679(00)00266-3

Cited by 38 publications

(17 citation statements)

References 6 publications

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“…Results are summarized in Table 3. Two of these reviews included a combined total of 93 exposed children aged 0 -12 years (8,52). The authors categorize toxic symptoms according to the AAPCC Toxic Exposure Surveillance System (TESS) definitions as mild (not requiring treatment), moderate (requiring treatment but not life-threatening), or severe (life-threatening), and identify either mean or minimum toxic and maximum non-toxic pediatric doses for individual CCBs.…”

Section: Resultsmentioning

confidence: 99%

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Are One or Two Dangerous? Calcium Channel Blocker Exposure in Toddlers

Ranniger

Roche

2007

The Journal of Emergency Medicine

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Section: Resultsmentioning

confidence: 99%

“…However, data from that study indicate that the lowest toxic dose of sustained-release nifedipine and verapamil, causing mild-moderate toxicity, corresponds to a single pill. Similarly, one death can be attributed to a single pill of regular nifedipine (52).…”

Section: Discussionmentioning

confidence: 99%

Are One or Two Dangerous? Calcium Channel Blocker Exposure in Toddlers

Ranniger

Roche

2007

The Journal of Emergency Medicine

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“…Children could be at particular risk of poisoning from calcium channel blockers due to the high dosage form strength in comparison to body weight (2,3). A single 10-mg nifedipine tablet was associated with the death of an infant (4).…”

Section: Introductionmentioning

confidence: 99%

Amlodipine Toxicity in Children Less Than 6 Years of Age: A Dose-Response Analysis Using National Poison Data System Data

Benson

Spyker

Troutman

et al. 2010

The Journal of Emergency Medicine

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“…Prior reports of nifedipine-related arrhythmias in children have been in young children who received nifedipine overdoses [14,15]. Many of these overdoses were fatal due to the development of asystole.…”

Section: Discussionmentioning

confidence: 99%

Ventricular arrhythmia following short-acting nifedipine administration

et al. 2005

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Short-acting nifedipine is still advocated for use in children with severe hypertension, but is no longer recommended for use in adults because of adverse effects from rapid blood pressure reduction. A 19 year-old adolescent with symptomatic, severe hypertension (blood pressure 180/120) received 10 mg of short-acting nifedipine sublingually for blood pressure reduction. Within minutes after the dose, the patient complained of palpitations. Tachycardia (heart rate 100 beats per minute) and bigeminy were noted on the cardiac monitor. The bigeminy resolved but premature ventricular contractions were noted for the duration of her hospital stay. We hypothesize that reflex sympathetic activation following an abrupt drop in blood pressure may cause arrhythmias because of elevated catecholamine levels. Given this, it may be more appropriate to treat severe hypertension in children with intravenous antihypertensive agents that can be titrated to produce controlled reductions in blood pressure.

show abstract

Fatal nifedipine ingestions in children

Cited by 38 publications

References 6 publications

Are One or Two Dangerous? Calcium Channel Blocker Exposure in Toddlers

Are One or Two Dangerous? Calcium Channel Blocker Exposure in Toddlers

Amlodipine Toxicity in Children Less Than 6 Years of Age: A Dose-Response Analysis Using National Poison Data System Data

Ventricular arrhythmia following short-acting nifedipine administration

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