Fatal Myositis Due to the Microsporidian<i>Brachiola algerae,</i>a Mosquito Pathogen

Coyle, Christina M.; Weiss, Louis M.; Rhodes, Luther V.; Cali, Ann; Takvorian, Peter M.; Brown, Daniel F.; Visvesvara, Govinda S.; Xiao, Lihua; Naktin, Jaan; Young, Eric; Gareca, Marcelo; Colasante, Georgia; Wittner, Murray

doi:10.1056/nejmoa032655

Cited by 122 publications

(133 citation statements)

References 33 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…However, infections did not persist or spread sufficiently to cause significant population declines. Because of their broad host ranges, including vertebrate infections by A. algerae (Coyle et al 2004), these microsporidia are no longer considered candidates as biological control agents (Becnel et al 2005;Andreadis 2007;Solter et al 2012). Both species are monomorphic with simple life cycles occurring in a single host and phylogenetically unrelated to a large clade of mosquito-infecting microsporidia.…”

Section: Mosquitoes: Amblyospora Connecticus and Edhazardia Aedismentioning

confidence: 99%

Microsporidia Biological Control Agents and Pathogens of Beneficial Insects

Bjørnson

2014

Microsporidia

View full text Add to dashboard Cite

Section: Mosquitoes: Amblyospora Connecticus and Edhazardia Aedismentioning

confidence: 99%

Microsporidia Biological Control Agents and Pathogens of Beneficial Insects

Bjørnson

2014

Microsporidia

View full text Add to dashboard Cite

“…The genus Trachipleistophora contains two species Trachipleistophora hominis (Hollister et al, 1996), which has caused myositis and Trachipleistophora anthropophthera (Vavra et al, 1998), which has been associated with encephalitis and disseminated infection in immune compromised patients. The genus Brachiola has three species that have been reported in human infections Brachiola vesicularum, Brachiola conorii and Brachiola algerae (Coyle et al, 2004). Vittaforma corneae infection has presented as corneal disease as well as a disseminated infection (Deplazes et al, 1998).…”

Section: Overviewmentioning

confidence: 99%

The microsporidian polar tube: A highly specialised invasion organelle

Weiss

2005

International Journal for Parasitology

Self Cite

124

103

View full text Add to dashboard Cite

All of the members of the Microsporidia possess a unique, highly specialised structure, the polar tube. This article reviews the available data on the organisation, structure and function of this invasion organelle. It was over 100 years ago that Thelohan accurately described the microsporidian polar tube and the triggering of its discharge. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation the polar tube rapidly discharges out of the spore pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell. The mechanism of germination of spores, however, remains to be definitively determined. In addition, further studies on the characterisation of the early events in the rupture of the anterior attachment complex, eversion of the polar tube as well as the mechanism of host cell attachment and penetration are needed in order to clarify the function and assembly of this structure. The application of immunological and molecular techniques has resulted in the identification of three polar tube proteins referred to as PTP1, PTP2 and PTP3. The interactions of these identified proteins in the formation and function of the polar tube remain to be determined. Data suggest that PTP1 is an O-mannosylated glycoprotein, a post-translational modification that may be important for its function. With the availability of the Encephalitozoon cuniculi genome it is now possible to apply proteomic techniques to the characterisation of the components of the microsporidian spore and invasion organelle.

show abstract

“…Among these species is A. algerae, which was originally isolated from the larvae of the Anopheles stephensis mosquito 2 and has one of the broadest known host ranges 3 . This species infects both immunocompetent and immuno-compromised patients 3,4 . Furthermore, the mosquitoes co-infected with A. algerae and Plasmodium falciparum exhibit reduced Plasmodium development, suggesting that A. algerae enforces a biological defence against the causative agent of malaria 5 .…”

mentioning

confidence: 99%

Annotation of microsporidian genomes using transcriptional signals

et al. 2012

View full text Add to dashboard Cite

High-quality annotation of microsporidian genomes is essential for understanding the biological processes that govern the development of these parasites. Here we present an improved structural annotation method using transcriptional DnA signals. We apply this method to re-annotate four previously annotated genomes, which allow us to detect annotation errors and identify a significant number of unpredicted genes. We then annotate the newly sequenced genome of Anncaliia algerae. A comparative genomic analysis of A. algerae permits the identification of not only microsporidian core genes, but also potentially highly expressed genes encoding membrane-associated proteins, which represent good candidates involved in the spore architecture, the invasion process and the microsporidianhost relationships. Furthermore, we find that the ten-fold variation in microsporidian genome sizes is not due to gene number, size or complexity, but instead stems from the presence of transposable elements. such elements, along with kinase regulatory pathways and specific transporters, appear to be key factors in microsporidian adaptive processes.

show abstract

Fatal Myositis Due to the MicrosporidianBrachiola algerae,a Mosquito Pathogen

Cited by 122 publications

References 33 publications

Microsporidia Biological Control Agents and Pathogens of Beneficial Insects

Microsporidia Biological Control Agents and Pathogens of Beneficial Insects

The microsporidian polar tube: A highly specialised invasion organelle

Annotation of microsporidian genomes using transcriptional signals

Contact Info

Product

Resources

About