Fatal Multisystem Toxicity After Co-Trimoxazole

Brøckner, J; Boisen, E

doi:10.1016/s0140-6736(78)93043-x

Cited by 17 publications

(1 citation statement)

References 8 publications

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“…Most reported cases describe a predominantly cholestatic illness, but hepatocellular hepatitis is also observed. Extrahepatic symptoms may suggest an allergic reaction with fever, rash, peripheral eosinophilia, and other organ involvement such as pulmonary lesions, pancreatitis, renal insufficiency, or lymphadenopathy (73,74). With discontinuation of therapy the illness usually lasts less than 3 months, but more persistent cholestasis (75) and some deaths have been reported (70,73,76).…”

Section: Antimicrobial Medicationsmentioning

confidence: 99%

Drug‐related Hepatotoxicity and Acute Liver Failure

Murray¹,

Hadžić

Wirth

et al. 2008

J. pediatr. gastroenterol. nutr.

122

104

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Drug-induced acute liver failure (ALF) accounts for approximately 20% of ALF in children and a higher percentage of ALF in adults. Although most patients experience milder drug hepatotoxic reactions such as hepatitis, cholestasis, or asymptomatic enzyme elevation, it is important to recognize the potential for progression to ALF. The most common cause of drug-induced ALF in children is acetaminophen (15% of all ALF in children in the United Kingdom and the United States), whereas other drugs such as antituberculous and antiepileptic therapy account for 5%. The pathogenesis of liver injury includes direct hepatotoxicity and idiosyncratic reactions for most drugs, although for others the mechanism of injury is assumed on the basis of clinical presentation and hepatic histological findings. We review the adult and pediatric literature of drug-induced hepatotoxicity and ALF, with special attention to commonly used or offending medications, mechanism of the toxicity, clinical presentation, diagnosis, treatment, and prognosis. Although most of the available information is based on experience in adult patients, we have included that which is applicable to children, or we have cited pediatric examples. Enhanced awareness of the potential hepatotoxicity of commonly prescribed medications may minimize the frequency of serious hepatotoxicity and ALF in pediatric patients.

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Section: Antimicrobial Medicationsmentioning

confidence: 99%