Fatal Meningitis in Patient with X-Linked Chronic Granulomatous Disease Caused by Virulent Granulibacter bethesdensis

Abstract

Granulibacter bethesdensis is a pathogen reported to cause recurrent lymphadenitis exclusively in persons with chronic granulomatous disease. We report a case of fatal meningitis caused by a highly virulent G. bethesdensis strain in an adolescent in Europe who had chronic granulomatous disease.

Functional neutrophil disorders: Chronic granulomatous disease and beyond

“…33 European strains of Granulibacter have been more severe in presentation. 34 Granulibacter requires special culture media, such as charcoal yeast extract and can be identified by 16S sequencing. 30,35 In some instances, after parenteral therapy with ceftriaxone, extended therapy with cefdinir has been effective as this can be a difficult organism to eradicate.…”

“…bethesdensis 33 . European strains of Granulibacter have been more severe in presentation 34 . Granulibacter requires special culture media, such as charcoal yeast extract and can be identified by 16S sequencing 30,35 .…”