Fatal malignant melanoma in a child with neurofibromatosis type 1

Abstract

Neurofibromatosis type 1 is an autosomal dominant disease and is considered one of the most commonly inherited diseases in humans. Malignant melanoma has been reported in up to 5% of patients with neurofibromatosis type 1. We report a young Saudi boy with neurofibromatosis type 1 who developed fatal metastatic malignant melanoma arising from giant melanocytic nevi within speckled lentiginous nevus (SLN).

Pigmented (melanotic) diffuse neurofibroma of the back in neurofibromatosis type 1

“…Further, malignant neurofibroma (malignant peripheral nerve sheath tumor, MPNST) may show pigmentation rendering it difficult to distinguish the tumor from a malignant melanoma [ 9 ]. Finally, the pigmentation disorder in NF1 may give rise to a malignant melanoma [ 10 ].…”

Melanocytic neoplasms in neurofibromatosis type 1: a systematic review

“…Histological findings were reported for 57 ( Notably, ocular melanomas made up 15.0% of all melanomas in NF1 patients versus 1.5% in the general population by the number of lesions (P < 0.001, Table 2). Antle et al, 1990 [26] Case report 5 7/8 high-quality case report Ball et al, 2005 [27] Case-control study 4 7/10 high-quality case-control study Barringer et al, 2006 [28] Case report 5 7/8 high-quality case report Ben-Izhak et al, 1995 [29] Case report 5 7/8 high-quality case report Bin Amer et al, 2007 [30] Case report 5 7/8 high-quality case report Brasfield et al, 1972 [6] Prevalence study 3 9/9 high-quality prevalence study Chen et al, 2004 [31] Case report 5 5/8 high-quality case report Chew et al, 2019 [32] Case report 5 7/8 high-quality case report Cohen et al, 2016 [33] Case report 5 6/8 high-quality case report Croxatto et al, 1981 [34] Case report 5 8/8 high-quality case report Duve et al, 1994 [35] Case report 5 6/8 high-quality case report Foley et al, 2015 [36] Case report 5 8/8 high-quality case report Friedman et al, 1998 [37] Case report 5 6/8 high-quality case report Gallino et al, 2000 [38] Case series 4 7/10 high-quality case series Giuffrida et al, 2017 [39] Case report 5 6/8 high-quality case report Guillot et al, 2004 [9] Case series 4 10/10 high-quality case series Gupta et al, 1986 [40] Case report 5 5/8 high-quality case report Haddad et al, 1991 [41] Case report 5 8/8 high-quality case report Hauth et al, 2018 [42] Case report 5 8/8 high-quality case report Hida et al, 2020 [43] Case report 5 6/8 high-quality case report Honavar et al, 2000 [44] Case report 5 6/8 high-quality case report Ishii et al, 2001 [45] Case report 5 8/8 high-quality case report Kilgore et al, 2020 [46] Case report 5 6/8 high-quality case report Knight et al, 1973 [7] Cohort study 3 10/11 high-quality cohort study Koga et al, 2018 [47] Case series 4 10/10 high-quality case series Landry et al, 2021 [1] Cohort study 3 10/11 high-quality cohort study Leoni et al, 2021 [48] Prevalence study 3 9/9 for prevalence studies Mastrangelo et al, 1979 [49] Case report 5 5/8 high-quality case report Medina Mendez et al, 2014 [50] Case report 5 7/8 high-quality case report…”

A Case of Eccrine Spiradenoma in a Patient with Neurofibromatosis

“…In the case of malignant melanoma, there is strong relevance to neurofibromatosis, because both conditions originate from the neural crest, and many cases have been reported [10][11][12] .…”