Fatal Legionella maceachernii pneumonia in Canada

Thomas, E. T.; Gupta, Nitin; Westhuizen, N G van der; Chan, E. C. S.; Bernard, Kathryn

doi:10.1128/jcm.30.6.1578-1579.1992

Cited by 11 publications

(2 citation statements)

References 7 publications

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“…Species other than L. pneumophila and M. avium are also human pathogens ( e.g. , L. feeleii , L. micdadei , M. kansasii , and M. abscessus ) ( Thomas et al , 1992 ; Mogami et al , 2016 ; Sfeir et al , 2018 ; Wang et al , 2019 ). Therefore, nanopore sequencing targeting full-length 16S rRNA genes was applied to obtain detailed phylogenetic information.…”

Section: Discussionmentioning

confidence: 99%

“…Other Legionella sequences affiliated with pathogenic L. maceachernii and L. micdadei were also detected. L. maceachernii , which was initially isolated from a portable water system, caused pneumonia in an immunocompromised patient, while L. micdadei caused Legionnaires’ disease or Pontiac fever ( Thomas et al , 1992 ; Wang et al , 2019 ).…”

Section: Discussionmentioning

confidence: 99%

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Dynamics of the Microbial Community and Opportunistic Pathogens after Water Stagnation in the Premise Plumbing of a Building

et al. 2022

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In premise plumbing, microbial water quality may deteriorate under certain conditions, such as stagnation. Stagnation results in a loss of disinfectant residual, which may lead to the regrowth of microorganisms, including opportunistic pathogens. In the present study, microbial regrowth was investigated at eight faucets in a building over four seasons in one year. Water samples were obtained before and after 24 h of stagnation. In the first 100‍ ‍mL after stagnation, total cell counts measured by flow cytometry increased 14- to 220-fold with a simultaneous decrease in free chlorine from 0.17–0.36‍ ‍mg L –1 to <0.02‍ ‍mg L –1 . After stagnation, total cell counts were not significantly different among seasons; however, the composition of the microbial community varied seasonally. The relative abundance of Pseudomonas spp. was dominant in winter, whereas Sphingomonas spp. were dominant in most faucets after stagnation in other seasons. Opportunistic pathogens, such as Legionella pneumophila , Mycobacterium avium , Pseudomonas aeruginosa , and Acanthamoeba spp., were below the quantification limit for real-time quantitative PCR in all samples. However, sequences related to other opportunistic pathogens, including L. feeleii , L. maceachernii , L. micdadei , M. paragordonae , M. gordonae , and M. haemophilum , were detected. These results indicate that health risks may increase after stagnation due to the regrowth of opportunistic pathogens.

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