Fatal invasive aspergillosis caused by Aspergillus niger after bilateral lung transplantation

Abstract

Aspergillus niger is usually considered to be a low virulence fungus, not commonly reported to cause invasive infections. Invasive pulmonary aspergillosis due to Aspergillus niger was diagnosed in a 43-year-old woman following bilateral lung transplantation. Intravenous voriconazole failed to control progression of the disease. Despite salvage therapy with a combination of voriconazole and caspofungin for 23 days, the patient developed massive hemoptysis leading to death. The authors report the clinical features and treatment of this case.

Luliconazole, a New Antifungal, vs Amphotericin B, Voriconazole, Posaconazole and Caspofungin against Clinical and EnvironmentalAspergillusNigri Complex

“…The increasing of fungal opportunistic infections among patients receiving intensive chemotherapy, hematological malignancies and transplant patients during last decades is remarkable [10,23,[26][27][28]. Invasive Aspergillus infections are one of the life threatening human disease.…”

Development of a nanostructured electrochemical immunosensor applied to the early detection of invasive aspergillosis

“…The walls of old houses may be contaminated with their spores [3]. The symptoms of IA can be nonspecific [4], causing cough, fever, hemoptysis, pleuritic pain, etc. Usually present one or more nodules with peribronchial infiltrate or pleural effusion.…”

“…Usually present one or more nodules with peribronchial infiltrate or pleural effusion. When this infection spreads to the brain it causes seizures, cerebral infarcts and meningitis [4]. Moreover, diagnosis of IA is challenging, because clinical and radiologic signs are very insensitive or nonspecific [4].…”

“…When this infection spreads to the brain it causes seizures, cerebral infarcts and meningitis [4]. Moreover, diagnosis of IA is challenging, because clinical and radiologic signs are very insensitive or nonspecific [4]. Tissue biopsy as a means of making the diagnosis is invasive and is not always possible, especially among patients with thrombocytopenia [3,4].…”

“…Moreover, diagnosis of IA is challenging, because clinical and radiologic signs are very insensitive or nonspecific [4]. Tissue biopsy as a means of making the diagnosis is invasive and is not always possible, especially among patients with thrombocytopenia [3,4]. Early diagnosis leading to prompt institution of appropriate therapy may result in improved patient outcomes.…”