Fatal intoxication with melperone

Stein, Sylvia; Schmoldt, A.; Schulz, Martin

doi:10.1016/s0379-0738(00)00201-2

Cited by 11 publications

(2 citation statements)

References 10 publications

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“…Our median value for clozapine in Group A (2.4 µg/g) is lower than previously published work (3.6 µg/g [18], 8.2 µg/g [19] and 8.8 µg/g [20]) but our median group B value (2.65 µg/g) is higher (0.4 µg/g [18]). The median group A value for melperone (3.8 µg/g) is lower compared to previous reports (17.1 µg/g [21]). Our median chlorpromazine value in group B (0.95 µg/g) is considerably lower than in a previous study (17.0 µg/g [30]).…”

Section: Comparison With Previous Studiescontrasting

confidence: 84%

Antipsychotics ⿿ Postmortem fatal and non-fatal reference concentrations

Söderberg

Wernvik

Tillmar

et al. 2016

Forensic Science International

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Section: Comparison With Previous Studiescontrasting

confidence: 84%

Antipsychotics ⿿ Postmortem fatal and non-fatal reference concentrations

Söderberg

Wernvik

Tillmar

et al. 2016

Forensic Science International

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“…Melperone is regarded to be a safe antipsychotic drug, and it has been widely used in old-age psychiatry on the continent due to its favourable profile with low antimuscarinergic activity, and a recent study found that Melperone treatment did not result in significant weight gain [10]. There is only one documented case of a fatal intoxication with Melperone [11], the authors describe extremely high concentrations of Melperone in the toxicological analysis and diazepam, and nordazepam and carbamazepine were also detected. …”

Section: Introductionmentioning

confidence: 99%

Auditing Clinical Outcomes after Introducing Off-Licence Prescribing of Atypical Antipsychotic Melperone for Patients with Treatment Refractory Schizophrenia

Röhricht

Gadhia²,

Alam

et al. 2012

The Scientific World Journal

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Aims and Method. To evaluate the practical utility of off-licence prescribing and clinical outcomes of treatment with atypical antipsychotic Melperone. Method: Prospective data collection on patient's clinical characteristics and outcomes. Results. 17 patients with a diagnosis of refractory schizophrenia were identified as suitable for off-license prescribing of Melperone and commenced treatment (13 were previously treated with Clozapine). Seven of those currently remain on Melperone (41%), and for six patents, the BPRS symptom scores reduced significantly over time (24–61%) additionally patients displayed improvements of their quality of life. Six patients were discontinued due to noncompliance and/or side effects. Melperone was ineffective in the other four patients. Clinical Implications. The example of a small group of patients responding well to a comparably safe and inexpensive atypical antipsychotic with favourable side effect profile should encourage clinicians to use this tool as third-line treatment and to conduct more systematic clinical research.

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Plasma vs heart tissue concentration in humans – literature data analysis of drugs distribution

Tylutki

Polak

2015

Biopharm & Drug Disp

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ABSTRACT:Little is known about the uptake of drugs into the human heart, although it is of great importance nowadays, when science desires to predict tissue level behavior rather than to measure it. Although the drug concentration in cardiac tissue seems a better predictor for physiological and electrophysiological changes than its level in plasma, knowledge of this value is very limited. Tissue to plasma partition coefficients (Kp) come to rescue since they characterize the distribution of a drug among tissues as being one of the input parameters in physiologically based pharmacokinetic (PBPK) models. The article reviews cardiac surgery and forensic medical studies to provide a reference for drug concentrations in human cardiac tissue. Firstly, the focus is on whether a drug penetrates into heart tissue at a therapeutic level; the provided values refer to antibiotics, antifungals and anticancer drugs. Drugs that directly affect cardiomyocyte electrophysiology are another group of interest. Measured levels of amiodarone, digoxin, perhexiline and verapamil in different sites in human cardiac tissue where the compounds might meet ion channels, gives an insight into how these more lipophilic drugs penetrate the heart. Much data are derived from postmortem studies and they provide insight to the cardiac distribution of more than 200 drugs. The analysis depicts potential problems in defining the active concentration location, what may indirectly suggest multiple mechanisms involved in the drug distribution within the heart.

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Fatal intoxication with melperone

Cited by 11 publications

References 10 publications

Antipsychotics ⿿ Postmortem fatal and non-fatal reference concentrations

Antipsychotics ⿿ Postmortem fatal and non-fatal reference concentrations

Auditing Clinical Outcomes after Introducing Off-Licence Prescribing of Atypical Antipsychotic Melperone for Patients with Treatment Refractory Schizophrenia

Plasma vs heart tissue concentration in humans – literature data analysis of drugs distribution

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