Fatal Infection of a Pet Monkey with<i>Human herpesvirus 1</i>

Huemer, Hartwig P.; Larcher, Clara; Czedik-Eysenberg, Thomas; Nowotny, Norbert; Reifinger, M.

doi:10.3201/eid0806.010341

Cited by 45 publications

(39 citation statements)

References 11 publications

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“…Based on the epidemiology of the cases in this study, it was verified that Neotropical primates are highly susceptible to HHV-1 (Melendez et al 1969, Murphy et al 1972, Bruno et al 1997, Juan-Sallés et al 1997, Huemer et al 2002, Matz--Rensing et al 2003, Schrenzel et al 2003, Hatt et al 2004, Lefaux et al 2004, Gozalo et al 2008, Longa et al 2011. This virus causes an acute and fatal disease in marmosets, characterized by multiple skin vesicles and ulcers as well as severe necrotizing meningoencephalitis (Juan-Sallés et al 1997, Hatt et al 2004, Lefaux et al 2004, Longa et al 2011.…”

Section: Discussionmentioning

confidence: 55%

“…Infection has been described in owl monkeys (Aotus trivirgatus and A. nancymae) (Melendez et al 1969, Gozalo et al 2008, white-faced Saki (Pithecia pithecia) (Schrenzel et al 2003) and marmosets (Callithrix sp.) (Murphy et al 1972, Juan-Sallés et al 1997, Huemer et al 2002, Matz--Rensing et al 2003, Hatt et al 2004, Lefaux et al 2004, resulting in lethal infection.…”

Section: Introductionmentioning

confidence: 99%

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Fatal Human herpesvirus 1 (HHV-1) infection in captive marmosets (Callithrix jacchus and Callithrix penicillata) in Brazil: clinical and pathological characterization

et al. 2014

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RESUMO.-[Infecção fatal por Herpesvirus simplex Tipo 1 (HHV-1) em saguis de cativeiro (Callithrix jacchus and Callithrix penicillata) no Brasil: caracterização clínica e patológica.] Infecção fatal por Herpesvirus simplex Tipo 1 (HHV-1) foi diagnosticada em 12 saguis de cativeiro (Callithrix jacchus e Callithrix penicillata) provenientes da região metropolitana de São Paulo, Estado de São Paulo. Os sinais clínicos foram variáveis entres os casos, no entanto, a maioria dos saguis afetados apresentavam sinais associados à replicação viral em epitélios: úlceras na cavidade oral, lín-gua e pele da face e hipersalivação; e no sistema nervoso central: prostração, convulsão e comportamento agressivo. Histologicamente, o principal achado foi meningoencefalite necrosante não supurativa difusa, leve a acentuada com gliose, vasculite e necrose neuronal. Inclusões intranucleares também foram observadas em encéfalo, cavidade oral, pele, glândula adrenal e plexo mioentérico. A imuno-histoquímica anti-HHV-1 confirmou a presença do antígeno viral em associação às lesões em encéfalo, mucosa oral e lingual, pele da face, glândula adrenal e plexo mioentéri-co. Em 7/8 saguis infectados foi detectada a presença de HHV-1 por reação em cadeia da polimerase (PCR) a partir de amostras de encéfalo. Conclui-se que HHV-1 causa uma infecção disseminada e fatal em saguis. Clinical signs were variable among the cases, but most affected marmosets presented signs associated with viral epithelial replication: oral, lingual and facial skin ulcers and hypersalivation, and viral replication in the central nervous system: prostration, seizure and aggressive behavior. Consistent microscopic findings were diffuse mild to severe nonsuppurative necrotizing meningoencephalitis with gliosis, vasculitis and neuronal necrosis. Additionally, in the brain, oral cavity, skin, adrenal gland and myoenteric plexus intranuclear inclusion bodies were present. Immunohistochemistry confirmed the presence of the HHV-1 antigen in association with lesions in the brain, oral and lingual mucosa, facial skin, adrenal gland and myoenteric plexus. HHV-1-specific polymerase chain reaction (PCR) analysis of the brain was carried out and the virus was detected in 7/8 infected marmosets. It is concluded that HHV-1 causes widespread fatal infection in marmosets.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Fatal Human herpesvirus 1 (HHV-1) infection in captive marmosets (Callithrix jacchus and Callithrix penicillata) in Brazil: clinical and pathological characterization

et al. 2014

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“…There is continuing concern that BV represents a potential threat to humans because of potential spread of this virus from pet monkeys or monkeys at primate centers to the human host. Whereas BV can be deadly to humans, similarly, HSV-1 infection of marmosets can be deadly (19,23,41,45). The pathogenesis of these viruses in humans and monkeys is likely multifactorial, but the results of our current studies suggest that receptor usage may in part be responsible for the dramatic differences in pathogenesis these virus cause during zoonotic transmission.…”

Section: Figmentioning

confidence: 99%

Herpes B Virus Utilizes Human Nectin-1 but Not HVEM or PILRα for Cell-Cell Fusion and Virus Entry

Fan

Amen

Harden

et al. 2012

J Virol

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e To investigate the requirements of herpesvirus entry and fusion, the four homologous glycoproteins necessary for herpes simplex virus (HSV) fusion were cloned from herpes B virus (BV) (or macacine herpesvirus 1, previously known as cercopithecine herpesvirus 1) and cercopithecine herpesvirus 2 (CeHV-2), both related simian simplexviruses belonging to the alphaherpesvirus subfamily. Western blots and cell-based enzyme-linked immunosorbent assay (ELISA) showed that glycoproteins gB, gD, and gH/gL were expressed in whole-cell lysates and on the cell surface. Cell -

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“…Interestingly, human HSV can also act as a 'killer virus' if transferred to certain new world monkey species (Huemer et al, 2002), indicating that the pathogenicity and virulence of herpesviruses are difficult to predict in different host environments. The DNA sequence of the gC gene of Cercopithecine herpesvirus type 1 reported in this paper has been deposited (30 October 1998) in EMBL under nucleotide accession no.…”

Section: Introductionmentioning

confidence: 99%

Cloning and expression of the complement receptor glycoprotein C from Herpesvirus simiae (herpes B virus): protection from complement-mediated cell lysis

Huemer

Wechselberger

Bennett

et al. 2003

Journal of General Virology

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Simian herpes B virus (SHBV) is the herpes simplex virus (HSV) homologue for the speciesMacaca. Unlike in its natural host, and unlike other animal herpesviruses, SHBV causes high mortality in accidentally infected humans. SHBV-infected cells, like those infected with HSV-1 and equine herpesvirus types 1 and 4, express complement C3 receptor activity. To study immunoregulatory functions involved in susceptibility/resistance against interspecies transmission, the SHBV glycoprotein C (gC SHBV ) gene (encoding 467 aa) was isolated. Sequence analysis revealed amino acid identity with gC proteins from HSV-2 (46?9 %), HSV-1 (44?5 %) and pseudorabies virus (21?2 %). Highly conserved cysteine residues were also noted. Similar to gC HSV-2 , gC SHBV is less glycosylated than gC HSV-1 , resulting in a molecular mass of 65 kDa if expressed in replication-deficient vaccinia virus Ankara. Stable transfectants expressing full-length gC SHBV on the cell surface induced C3 receptor activity and were substantially protected from complement-mediated lysis; no protection was observed with control constructs. This suggests that expression of the gC homologues on infected cell surfaces might also contribute to the survival of infected cells in addition to decreased virion inactivation. Interestingly, soluble gC SHBV isolated from protein-free culture supernatants did not interfere with the binding of the alternative complement pathway activator properdin to C3b, which is similar to our findings with gC HSV-2 and could be attributed to major differences in the amino-terminal portion of the protein with extended deletions in both gC SHBV and gC HSV-2 . Binding of recombinant gC SHBV to polysulphates was observed. This, together with the heparin-sensitivity of the gC SHBV -C3 interaction on the infected cell surface, suggests a role in adherence to heparan sulphate, similar to the gC proteins of other herpesviruses.

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Fatal Infection of a Pet Monkey withHuman herpesvirus 1

Cited by 45 publications

References 11 publications

Fatal Human herpesvirus 1 (HHV-1) infection in captive marmosets (Callithrix jacchus and Callithrix penicillata) in Brazil: clinical and pathological characterization

Fatal Human herpesvirus 1 (HHV-1) infection in captive marmosets (Callithrix jacchus and Callithrix penicillata) in Brazil: clinical and pathological characterization

Herpes B Virus Utilizes Human Nectin-1 but Not HVEM or PILRα for Cell-Cell Fusion and Virus Entry

Cloning and expression of the complement receptor glycoprotein C from Herpesvirus simiae (herpes B virus): protection from complement-mediated cell lysis

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