Fatal<i>Trichoderma</i><i>harzianum</i>infection in a leukemic pediatric patient

Kantarcıoğlu, A. Serda; Çelkan, Tiraje; Yücel, Ayhan; Mikami, Yuzuru; Kuruğoğlu, Sebuh; Mitani, Hiroki; Altaş, Kemal

doi:10.1080/13693780802406225

Cited by 28 publications

(25 citation statements)

References 42 publications

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“…have been reported from deep tissue infections, mainly affecting the peritoneum and brain, followed by respiratory and other infection sites (4,6,8,17,61). The species studied here were mainly found in human respiratory specimens, followed by deep tissue and superficial tissue samples in similar amounts.…”

Section: Discussionmentioning

confidence: 75%

“…Apart from species of the Longibrachiatum clade, several clinical cases have been attributed to other Trichoderma species (4,8,26,61). Three clinical cases have been associated with T. harzianum, although the fungus was identified by ITS sequencing in only two of them (5,8,62).…”

Section: Discussionmentioning

confidence: 99%

“…Three clinical cases have been associated with T. harzianum, although the fungus was identified by ITS sequencing in only two of them (5,8,62). The Harzianum clade was the second most common in our study and, unlike the Longibrachiatum clade, it included isolates from humans and animals.…”

Section: Discussionmentioning

confidence: 99%

“…DNA sequence analysis has helped clarify the taxonomy of Trichoderma, and several new species have been described based on multigene phylogenies (39,41,42). In the clinical setting, species identification has been based mainly on ribosomal DNA (rDNA) sequences (8,23,28,40), although it has been shown that the use of this locus does not provide sufficient resolution to accurately distinguish closely related species (4,26,41,43). This, together with the poor in vitro activities of commonly used antifungals against Trichoderma isolates, is an impediment for the treatment of Trichoderma infections (11,43) and limits our understanding of the epidemiology of the species.…”

mentioning

confidence: 99%

“…Trichoderma infections in humans have been related with several risk factors, being associated mostly with peritoneal dialysis, organ transplantation, and hematologic disorders (4). They cause severe and persistent disseminated infections that usually fail to respond to treatment with amphotericin B (AMB) or voriconazole (VRC) (5)(6)(7)(8)(9). Other diseases attributed to members of this genus are allergic and acute invasive sinusitis (10,11), keratitis (12), otitis externa (13), skin and subcutaneous infections (14), peritonitis (9,(15)(16)(17)(18)(19)(20), deep pulmonary infections (21)(22)(23), endocarditis (24), and brain abscess (25).…”

mentioning

confidence: 99%

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Phylogeny of the Clinically Relevant Species of the Emerging Fungus Trichoderma and Their Antifungal Susceptibilities

et al. 2014

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A set of 73 isolates of the emerging fungus Trichoderma isolated from human and animal clinical specimens were characterized morphologically and molecularly using a multilocus sequence analysis that included the internal transcribed spacer (ITS) regions of the nuclear ribosomal DNA and fragments of the translation elongation factor 1 alpha (Tef1), endochitinase CHI18-5 (Chi18-5), and actin 1 (Act1) genes. The most frequent species was Trichoderma longibrachiatum (26%), followed by Trichoderma citrinoviride (18%), the Hypocrea lixii/Trichoderma harzianum species complex (15%), the newly described species Trichoderma bissettii (12%), and Trichoderma orientale (11%). The most common anatomical sites of isolation in human clinical specimens were the respiratory tract (40%), followed by deep tissue (30%) and superficial tissues (26%), while all the animal-associated isolates were obtained from superficial tissue samples. Susceptibilities of the isolates to eight antifungal drugs in vitro showed mostly high MICs, except for voriconazole and the echinocandins.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Phylogeny of the Clinically Relevant Species of the Emerging Fungus Trichoderma and Their Antifungal Susceptibilities

et al. 2014

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Peptaibol, Secondary‐Metabolite, and Hydrophobin Pattern of Commercial Biocontrol Agents Formulated with Species of the Trichoderma harzianum Complex

Degenkolb¹,

Nielsen

Dieckmann³

et al. 2015

Chemistry & Biodiversity

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The production of bioactive polypeptides (peptaibiotics) in vivo is a sophisticated adaptation strategy of both mycoparasitic and saprotrophic Trichoderma species for colonizing and defending their natural habitats. This feature is of major practical importance, as the detection of peptaibiotics in plant-protective Trichoderma species, which are successfully used against economically relevant bacterial and fungal plant pathogens, certainly contributes to a better understanding of these complex antagonistic interactions. We analyzed five commercial biocontrol agents (BCAs), namely Canna(®) , Trichosan(®) , Vitalin(®) , Promot(®) WP, and TrichoMax(®) , formulated with recently described species of the Trichoderma harzianum complex, viz. T. afroharzianum, T. simmonsii, and T. guizhouense. By using the well-established, HPLC/MS-based peptaibiomics approach, it could unequivocally be demonstrated that all of these formulations contained new and recurrent peptaibols, i.e., peptaibiotics carrying an acetylated N-terminus, the C-terminus of which is reduced to a 1,2-amino alcohol. Their chain lengths, including the amino alcohol, were 11, 14, and 18 residues, respectively. Peptaibols were also to be the dominating secondary metabolites in plate cultures of the four strains obtained from four of the Trichoderma- based BCAs, contributing 95% of the UHPLC-UV/VIS peak areas and 99% of the total ion count MS peak area from solid media. Furthermore, species-specific hydrophobins, as well as non-peptaibiotic secondary metabolites, were detected, the latter being known for their antifungal, siderophore, or plant-growth-promoting activities. Notably, none of the isolates produced low-molecular weight mycotoxins.

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Advances in Microbiology, Infectious Diseases and Public Health: Fungal Occurrence in the Hair and Skin of Symptomatic Pets in Turin, Italy

Allizond

Tullio

Cuffini

et al. 2015

Advances in Experimental Medicine and Biology

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Companion animals, often asymptomatic reservoir of fungi, can be important sources of infection in humans, due to the close contact with their owners. The present study was aimed to assess the occurrence of dermatophytes and other fungi isolated from pet dermatological lesions in Turin, Italy. Dermatological specimens were examined for fungal elements by direct microscopy and cultured to detect dermatophytes, other filamentous fungi and yeasts: 247 pets (118 cats, 111 dogs and 18 dwarf rabbits) were positive for fungal detection in culture. Microsporum canis was the most frequent dermatophyte in cats and dogs, whereas Trichophyton mentagrophytes was the most common in rabbits. Among the other fungi, for all examined pets, dematiaceous fungi were the most isolated, followed by Mucorales, penicilli, yeasts and yeast-like fungi, and aspergilli. No gender predisposition was detected for dermatophyte growth; on the contrary, for the other fungi male cats were more susceptible than female. The highest fungal occurrence was recorded in <1-year-old cats for dermatophytes, and in <5-year-old cats and dogs for the other fungi. Autumn was the period associated with a relevant incidence of fungal infection. Finally, fungi were more frequent in non pure-breed cats and in pure-breed dogs. These data underline the importance to timely inform pet owners about the potential health risk of infection caused not only by dermatophytes but also by non-dermatophyte fungi, routinely considered to be contaminants or harmless colonizers, since their role as source of zoonotic infections is not to be excluded.

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FatalTrichodermaharzianuminfection in a leukemic pediatric patient

Cited by 28 publications

References 42 publications

Phylogeny of the Clinically Relevant Species of the Emerging Fungus Trichoderma and Their Antifungal Susceptibilities

Phylogeny of the Clinically Relevant Species of the Emerging Fungus Trichoderma and Their Antifungal Susceptibilities

Peptaibol, Secondary‐Metabolite, and Hydrophobin Pattern of Commercial Biocontrol Agents Formulated with Species of the Trichoderma harzianum Complex

Advances in Microbiology, Infectious Diseases and Public Health: Fungal Occurrence in the Hair and Skin of Symptomatic Pets in Turin, Italy

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