Fatal Herpes Simplex Hepatitis in a Newborn Infant

McDougal, Robert A.; Beamer, Parker R.; Hellerstein, Stanley

doi:10.1093/ajcp/24.11.1250

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Neonatal Herpes1

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1961

1989

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Cited by 20 publications

(1 citation statement)

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“…Similarly the changes associated with neonatal herpetic hepatitis do not appear to be very different from those described in older children and adults with massive necrosis, haemorrhage and lack of inflammatory cell infiltrate (Hass 1935;Zueler and Stulberg 1952;Wright and Miller 1965;McDougal et al 1954;Singer 1981).…”

Section: Neonatal Herpesmentioning

confidence: 87%

Herpes Simplex Virus

Mindel¹

1989

The Bloomsbury Series in Clinical Science

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Section: Neonatal Herpesmentioning

confidence: 87%

Herpes Simplex Virus

Mindel¹

1989

The Bloomsbury Series in Clinical Science

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Transplacental Infection by Herpes Simplex Virus

Mitchell¹

1963

Arch Pediatr Adolesc Med

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One of the more common viral infections affecting man is that caused by the herpes simplex virus. Its most common manifestation, the "fever blister," is so familiar to the layman that a medical diagnosis is not sought.However, the manifestations of the herpes virus are so protean that they may range from severe encephalitis, to the moderately severe stomatitis frequently seen in the very young, to the mild "fever blister" just mentioned. The more severe manifestations are due to a primary infection which occurs after an incubation period of three to five days, whereas the "fever blister" is felt to be the result of an upset in an otherwise symbiotic relationship between host and virus. Between 65% and 98% of adults, depending on areas sampled, will show neutralizing antibodies to the herpes simplex virus.Since the initial case report of herpes simplex infection in the newborn by Haas 1 in 1935 it has been recognized that the herpes virus is capable of producing a widespread disseminated disease of the newborn which involves structures of ectodermal origin as well as those of entodermal and mesodermal origin. After this report by Haas, Zuelzer,2 in 1952, reported five infants with pathologi¬ cal evidence of disseminated herpetic infec¬ tion, one of which was proved on culture to have been caused by the herpes simplex virus. This report and subsequent ones have described the disease as being characterized by the onset of a systemic reaction on or about the fifth to seventh day post delivery with fever or hypothermia, increasing icterus, lethargy, respiratory distress, vomiting, dyspnea, cyanosis, and with rapid develop-

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Herpes simplex virus infection in the pregnant hamster

Ferm

Low

1965

J. Pathol.

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Fatal Herpes Simplex Hepatitis in a Newborn Infant

Cited by 20 publications

References 12 publications

Herpes Simplex Virus

Herpes Simplex Virus

Transplacental Infection by Herpes Simplex Virus

Herpes simplex virus infection in the pregnant hamster

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