Fatal hepatic failure following accidental tramadol overdose

Loughrey, Maurice B.; Loughrey, C.; Johnston, S.; O’Rourke, Dorcas P.

doi:10.1016/s0379-0738(03)00132-4

Cited by 58 publications

(51 citation statements)

References 5 publications

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“…It is our view that the decrease in the liver enzymes as the duration of drug administration proceeds may be due to severe or terminal liver failure that resulted to the inability of the liver cells to produce enzymes. The severe liver failure may be due to prolonged This result is largely in agreement with the findings of [24], who reported that tramadol administration in adult male rats for one month was accompanied by hepatic congestion, hemorrhage and necrosis. Similar findings was also reported by [25], who revealed loss of architecture, congested central veins, expanded portal area with edema and inflammatory reaction in rats treated with tramadol.…”

Section: Discussionsupporting

confidence: 90%

Some Marker Enzymes and Histological Alteration on the Administration of Tramadol Hydrochloride on Rat Liver

Simeon¹,

Abbey²

2018

MRI

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The ease of availability and potential tendency to abuse tramadol hydrochloride prompted this research. Making use of biochemical and histological techniques, concentrations of marker enzymes were monitored along with alterations in the liver architecture of wistar albino rats in graded doses of tramadol hydrochloride for 28 days. Specifically, levels of gammaglutamyltransferase (Ɣ-GT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. Statistical evaluation of the results at a p < 0.05 elucidated significantly elevated values of these enzymes when compared with controls that were not on tramadol hydrochloride. The variations were time and dose dependent. Histological evaluation presented various degrees of inflammatory cells of the liver, cytolysis in hepatocytes and some portal tract hypertrophy. These findings support the need for caution in administration of tramadol particularly for long term administration.

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Section: Discussionsupporting

confidence: 90%

Some Marker Enzymes and Histological Alteration on the Administration of Tramadol Hydrochloride on Rat Liver

Simeon¹,

Abbey²

2018

MRI

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“…It has been approved in some countries since 1980 and become the most prescribed opioid worldwide [3,4]. Tramadol was authorized by the Iran Drug Selecting Committee in 2002 as an analgesic.…”

Section: Introductionmentioning

confidence: 99%

“…Tramadol binds weakly to the μ-opioid receptor and also inhibits reuptake of monoamines such as serotonin and norepinephrine [2][3][4][5]. Most of the analgesic effect of tramadol may be secondary to non-opioid properties, via the central monoaminergic pathways.…”

Section: Introductionmentioning

confidence: 99%

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Factors Related to Seizure in Tramadol Poisoning and Its Blood Concentration

et al. 2011

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“…La gravité de ces intoxications est plus souvent liée aux associations médicamenteuses (benzodiazépines, antidépresseurs tricycliques et inhibiteurs de la recapture de la sérotonine) qu'au tramadol seul (4, 9, 10) avec une potentialisation de la toxicité liée à la composante monoaminergique du tramadol. Seulement deux cas d'intoxications mortelles au tramadol ont été rapportés (3,11 . Concernant les médicaments associés retrouvés, tous sites confondus nous constatons que le tramadol est plus souvent associé aux antidépresseurs et aux neuroleptiques que le dextropropoxyphène.…”

Section: Signes Cliniquesunclassified