Fatal hemolytic transfusion reaction resulting from ABO mistyping of a patient with acquired B antigen detectable only by some monoclonal anti‐ B reagents

Garratty, George; Arndt, Patricia A.; Co, Asuncion; Rodberg, Karen; Furmanski, M

doi:10.1046/j.1537-2995.1996.36496226152.x

Cited by 36 publications

(25 citation statements)

References 9 publications

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“…Results of blood typing can be affected by disease states in humans22 and animals 15,g. For example, FeLV infection and other diseases may cause anemia and auto agglutination and may thereby contribute to test inaccuracies as detected in the present study.…”

Section: Discussionmentioning

confidence: 99%

Comparison of five blood-typing methods for the feline AB blood group system

Seth

Jackson²,

Giger³

2011

ajvr

108

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Objective To compare the ease of use and accuracy of 5 feline AB blood-typing methods: card agglutination (CARD), immunochromatographic cartridge (CHROM), gel-based (GEL), and conventional slide (SLIDE) and tube (TUBE) agglutination assays. Sample Population 490 anticoagulated blood samples from sick and healthy cats submitted to the Transfusion or Clinical Laboratory at the Veterinary Hospital of the University of Pennsylvania. Procedures Sample selection was purposely biased toward those from anemic, type B, or type AB cats or those with autoagglutination. All blood samples were tested by use of GEL, SLIDE, and TUBE methods. Fifty-eight samples were also tested by use of CARD and CHROM methods. The presence of alloantibodies in all cats expressing the B antigen as detected by use of any method was also assessed. Results Compared with the historical gold-standard TUBE method, good to excellent agreement was achieved with the other typing tests: CARD, 53 of 58 (91% agreement); CHROM, 55 of 58 (95%); GEL, 487 of 490 (99%); and SLIDE, 482 of 487 (99%; 3 samples were excluded because of autoagglutination). Four of the samples with discordant test results originated from cats with FeLV-related anemia. Conclusions and Clinical Relevance Current laboratory and in-clinic methods provide simple and accurate typing for the feline AB blood group system with few discrepancies. Retyping after in-clinic typing with the GEL or TUBE laboratory methods is recommended to confirm any type B or AB cats.

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Section: Discussionmentioning

confidence: 99%

Comparison of five blood-typing methods for the feline AB blood group system

Seth

Jackson²,

Giger³

2011

ajvr

108

View full text Add to dashboard Cite

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“…The approach of using FC to detect transfused RBCs in humans usually has been to use an antigen that is present on the transfused RBCs and is not present on the RBCs of the recipient (86)(87)(88)(89)(90)(91)(92)(93). Investigators at the New York Blood Center used the opposite approach, of detecting an antigen present on the recipient but absent from the transfused RBCs (76,(94)(95)(96).…”

Section: Detection and Quantitation Of Transfused Rbcs (Rbc Survival mentioning

confidence: 99%

Applications of flow cytofluorometry to red blood cell immunology

Garratty

Arndt

1999

Cytometry

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“…wegen Antikörpermangels, nicht aussagekräftig ist. In Extremfällen, wenn auch noch die Kreuzprobe mit unzulänglichen Techniken durchgeführt wird, kann daraus sogar eine Fehltransfusion mit schwerem hämolytischen Transfusionszwischenfall resultieren [58]. Abschließend sei erwähnt, daß es noch eine weitere Ursache für ein Bacq geben kann, die Adsorption bakterieller Polysaccharide mit B-ähnlichen Eigenschaften an menschliche Erythrozyten [59,60].…”

Section: Das Erworbene B-antigenunclassified

Erworbene Veränderungen der erythrozytären AB0-Merkmale

Strobel¹

2000

Transfus Med Hemother

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Objective: Pathological changes of the ABO antigens on red blood cells are rare events, but they are important in blood group serology because of the risk of false results in ABO typing. This review is designed to show these pathological changes and the problems in ABO testing caused by them, especially if monoclonal reagents are used. Sources: Selected literature and own experiences. Results: The most relevant pathological changes of the ABO antigens are: 1) The depression of the A- and/or B-antigen on some or (nearly) all red blood cells of some patients with leukemia or myeolodysplastic syndrome. This change is caused by a reduced activity of ABH glycosyltransferases. 2) The acquired B-antigen in some pa-tients with gastrointestinal diseases and/or bacteremia. It is caused by a deacetylation of the A-antigen leading to a B-like antigen. 3) The ‘acquired A-like antigen’ in cases of Tn polyagglutinability which is caused by the cross-reactivity of some anti-A reagents with the Tn antigen. It has been found in cases of leukemia, but also in healthy persons. Conclusions: Although reagents of high quality are used for ABO typing, testing for ABO isoantibodies in the serum is still indispensable. Monoclonal antibodies that are cross-reactive with the acquired B-antigen or with Tn-positive red blood cells should not be used for ABO typing.

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Fatal hemolytic transfusion reaction resulting from ABO mistyping of a patient with acquired B antigen detectable only by some monoclonal anti‐ B reagents

Abstract: A fatal hemolytic transfusion reaction resulted because a monoclonal anti-B that detected acquired B antigen was used to type red cells from an elderly man whose serum had weak anti-B that was not detected by abbreviated compatibility testing.

Cited by 36 publications

References 9 publications

Comparison of five blood-typing methods for the feline AB blood group system

Comparison of five blood-typing methods for the feline AB blood group system

Applications of flow cytofluorometry to red blood cell immunology

Erworbene Veränderungen der erythrozytären AB0-Merkmale

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