Fatal Hemolytic Transfusion Reaction Caused by Sensitization to a New Blood Factor U

The MN Gene MU, which Produces M and U but no N, S, or s

“…Elutions were done by the method of Weiner [5]. (Table YI) and elutions (Table VII) confirm the results of the direct tests in showing that he is truly s -.…”

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Anti-U [5] was shown by Greenwalt, Sasaki, Sanger, Sneath and Race to be an antibody of the MN S system. AU U -bloods were found to be S-s -[2], and subsequent testing has not revealed a blood that isU-S + orU-s+.

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A Study of the S^u Alleles in Northeastern Brazil

“…The preponderance of N* over M* is highly significant by comparison with the N gene frequency of 0.45 (%2 = 12, P < 0.001). Wiener et al (1953Wiener et al ( , 1954 first noted an association between anti-U and the MN factors, and from this suggested that S-s-phenotypes are determined by alleles at the MNS locus. This inference is supported by the fact that ordinary genes that produce M also produce a weak N antigen, but the MU gene does not (Allen et al, 1963).…”

Blood Groups of Apes and Monkeys

“…T hat anti-N agglutinins m ay be pre sent in all or almost all sera from rabbits immunized with type M cells, has been shown recently by F ig u r and R o sen fiel d [subm itted for pub lication] by absorbing such antisera with blood of type M.u, th at is rare blood of the type M lacking the blood factor U of W ie n e r , U n ger and Gordon [1953].…”