Fatal Disseminated Toxoplasmosis During Primary HIV Infection

Signorini, Liana; Gulletta, Maurizio; Coppini, Davide; Donzelli, Carla; Stellini, Roberto; Manca, N.; Carosi, Giampiero; Matteelli, Alberto

doi:10.2174/157016207780077011

Cited by 11 publications

(10 citation statements)

References 7 publications

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“…Depending on social and cultural habits, geographic factors, climate, and transmission routes prevalence of this infection varies widely between different countries (10-80 %) (Robert-Gangneux and Darde 2012). The importance of toxoplasmosis mainly lies among pregnant women (due to the risk of transmission to fetus), transplant recipients and patients with acquired immunodeficiency syndrome (Derouin and Pelloux 2008;Signorini et al 2007;Sukthana 2006). The incidence of maternal infection during pregnancy is 1-8 per 1000 pregnancies.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Toxoplasma gondii infection among childbearing age women in Kerman city, southeastern Iran

et al. 2015

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This cross-sectional study aims to determine the prevalence of IgM and IgG anti-T. gondii antibodies and the associated risk factors among childbearing age women referring to counseling centers before marriage in Kerman city, southeast of Iran. Totally, 300 serum samples were collected from women referred to Central Laboratory for Marriage Consultation in Kerman city were screened for IgG and IgM anti-T. gondii antibodies by enzyme linked immunosorbent assay (ELISA). Out of the 300 serum samples, 38 (12.6 %) tested seropositive for anti-T. gondii antibodies; 31 (10.3 %) samples tested seropositive for only IgG antibody, 1 (0.33 %) tested seropositive for both IgM and IgG and 6 (2.0 %) were positive for IgM antibody alone. Statistical analyses also indicated that seroprevalence of anti-T. gondii antibodies increased with age (p \ 0.05). Moreover, some risk factors such as, living in rural regions, contact with cats, raw/half-cooked meat consumption, and agricultural activities were significantly (p \ 0.05) related to T. gondii seropositivity. The findings revealed that more than three-quarters of the childbearing age women studied in the present investigation are susceptible to infection during pregnancy. Thus, by adopting correct and improved practices we can improve their living conditions, and prevent infection and awareness and control of pathogens associated with disease is recommended.

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Section: Introductionmentioning

confidence: 99%

Seroprevalence of Toxoplasma gondii infection among childbearing age women in Kerman city, southeastern Iran

et al. 2015

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“…T. gondii is an important cause of abortion in sheep and goats (Dubey and Beattie 1988). Toxoplasmosis also has a major public health concern because this disease is serious in terms of mortality or physical and/or psychological sequelae in patients with HIV disease and in congenitally infected neonates (Biesiada et al 2006;Signorini et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of and risk factors for Toxoplasma gondii antibodies among asymptomatic blood donors in Egypt

et al. 2009

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A cross-sectional study was conducted to evaluate the seroprevalence of and risk factors for Toxoplasma gondii antibodies in 260 blood donors seen at blood banks in Mansoura University Hospital, Egypt. Blood donors were interviewed about sociodemographic characteristics and risk factors for T. gondii infection. A blood sample was taken to document their T. gondii antibody status using enzyme-linked immunosorbent assay. Overall, 155 (59.6%) of 260 blood donors were positive for anti-T. gondii IgG antibodies. Multivariate logistic regression analysis showed a significant association between T. gondii seropositivity and eating meat by-products (luncheon/shawerma) (adjusted odds ratio [OR] 80.82 [95% CI 18.62-350.81], P < 0.0001) or being non-educated (adjusted OR 32.25 [95% CI 7.46-139.44], P < 0.0001). These findings highlight that T. gondii is prevalent among blood donors in Egypt.

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“…But toxoplasmosis in immunocompromised individuals and the fetus can cause serious and fatal symptoms (Signorini et al, 2007;Torgerson & Mastroiacovo, 2013). Nowadays, the diagnosis of human toxoplasmosis is usually based on the detection of the anti T.-gondii antibodies by serological methods including ELISA, latex agglutination (LA), and indirect fluorescent antibody (IFAT) (RobertGangneux & Darde, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…The disease in the immunocompetent adults and children are generally without symptoms or cover gentle and impulsively resolved signs; for example, fever, fatigue, lethargy and lymphadenopathy (Furtado, 2011;Mahmoudvand, 2016). On the other hand, toxoplasmosis in immunocompromised patients such as transplant recipients and patients with acquired immunodeficiency syndrome and the fetus can give rise to serious and fatal symptoms such as eye infection and brain involvements (Signorini et al, 2007;Torgerson & Mastroiacovo, 2013). The diagnosis of T. gondii infection is usually based on serological tests to find the anti-T. gondii antibodies; so that IgM and IgG anti-T. gondii antibodies are typically wellknown as a indicator of acute and chronic infection respectively (Hill & Dubey, 2002).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence Of Toxoplasma Gondii Antibodies And Associated Risk Factors Among Children In Lorestan Provinces, Iran

Mahmoudvand¹,

Kheirandish²,

Faramarzi³

et al. 2017

European Proceedings of Social and Behavioural Sciences

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Children due to their high hand-mouth activity, lack of hygiene standards in the consumption of food, water, fruits and vegetables and their immature immune systems are the most susceptible peoples to parasitic infections among all age groups. This cross-sectional study aims to determine the prevalence of IgM and IgG anti-Toxoplasma gondii antibodies and the associated risk factors among the Children (5-15 yr Old) Referred to health centres of Lorestan province, Iran from August 2016 to March 2017 on 316 children. To determine the anti-T. gondii antibodies, all the serum samples were tested using the commercially available ELISA kit (Dia.Pro, Milano, Italy). Analyses were carried out according to the manufacturer's instructions. Out of the 316 children, 31 (9.8%) tested seropositive for anti-T. gondii antibodies; 24 (7.6%) children tested seropositive for IgG antibody, 1 (0.3%) tested seropositive for both IgM and IgG, and 6 (1.9%) were positive for IgM antibody alone. The results showed that some risk factors were significantly correlated to T. gondii seropositivity included age (P= 0.005), living in rural areas (P=0.01) and consumption of undercooked or cured meat products (P<0.001). The findings of our study demonstrated a considerable seroprevalence of T. gondii infection in children in Lorestan province, Iran. Thus, proper strategies must be carried out to prevent and control T. gondii infection in children in this region.

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Fatal Disseminated Toxoplasmosis During Primary HIV Infection

Cited by 11 publications

References 7 publications

Seroprevalence of Toxoplasma gondii infection among childbearing age women in Kerman city, southeastern Iran

Seroprevalence of Toxoplasma gondii infection among childbearing age women in Kerman city, southeastern Iran

Seroprevalence of and risk factors for Toxoplasma gondii antibodies among asymptomatic blood donors in Egypt

Seroprevalence Of Toxoplasma Gondii Antibodies And Associated Risk Factors Among Children In Lorestan Provinces, Iran

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