Fatal Disseminated Infection by Trichosporon asahii Under Voriconazole Therapy in a Patient with Acute Myeloid Leukemia: A Review of Breakthrough Infections by Trichosporon spp.

Ramírez, Isabel; Moncada, Diana Carolina

doi:10.1007/s11046-019-00416-w

Cited by 19 publications

(26 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It commonly causes disseminated infections in immunocompromised patients 2,3 and results in death in 80 percent of affected patients 3 . Severely neutropenic oncology patients are especially vulnerable 3,4 . Skin manifestations vary, but usually present as purpuric, papulonodular or pustular lesions, and can have central necrosis 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Management with triazoles, 1,5 particularly voriconazole 1,4 independently or in combination 3,4 with amphotericin B, appears to achieve favorable response. However, breakthrough infection can occur in patients with prolonged triazole exposure due to drug resistance 4 . Prophylaxis or treatment with echinocandins is generally ineffective 4 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A rare case of cutaneous Trichosporon asahii infection in an immunocompromised child

Lee

Koh

2020

Pediatric Dermatology

View full text Add to dashboard Cite

We present an 11-year-old girl who developed neutropenic fever and papulonodular lesions over her limbs and back following chemotherapy for relapsed acute myeloid leukemia. She was found to have cutaneous Trichosporon asahii infection, with no evidence of systemic infection, and responded to treatment with voriconazole. T. asahii infection is rare but often fatal and usually causes disseminated infections in immunocompromised patients. Cutaneous infection is relatively uncommon and rarely occurs in the pediatric population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A rare case of cutaneous Trichosporon asahii infection in an immunocompromised child

Lee

Koh

2020

Pediatric Dermatology

View full text Add to dashboard Cite

show abstract

“…The mortality rate reported in this study was 68.7%, and both neutropenia and the presence of venous catheters were considered as crucial factors for developing infection. 131 Furthermore, Suzuki et al reported that TF occurred as a B-IFI during antifungal therapy in 30 patients (91%), 18 of whom were receiving micafungin. Therefore, they suggested that along with using antifungals without anti-Trichosporon activity, further care is needed to prevent the development of breakthrough trichosporonosis.…”

Section: Trichosporonosismentioning

confidence: 99%

“…Generally, underlying diseases accompanied by neutropenia are mostly accompanied by deleterious outcomes. 131 Recent studies have shown that the tendency for trichosporonosis to evade detection on blood culture and to resemble other better-known pathogens such as Candida on histology present additional diagnostic challenges. 241 It has been suggested that compared with Candida, Trichosporon has thinner hyphae and pseudohyphae, and stain slightly on Gomori methenamine silver (GMS) in comparison to other fungi.…”

Section: Trichosporonosismentioning

confidence: 99%

“…244 MDR Trichosporon has been reported with AMB, echinocandins, flucytosine, fluconazole, and itraconazole. 131,233,236 Another study reported that during multi-agent chemotherapy, two patients with hematologic malignancy developed endophthalmitis as a result of T. beigelii infection. Trichosporonous endophthalmitis in these patients was resistant to fluconazole and 5-fluorocytosine, and in both cases, systematic treatment with AMB efficiently resolved this infection, which was resistant to antifungal therapeutics.…”

Section: Trichosporonosismentioning

confidence: 99%

See 1 more Smart Citation

<p>An Overview of the Management of the Most Important Invasive Fungal Infections in Patients with Blood Malignancies</p>

Shariati¹,

Moradabadi²,

Chegini³

et al. 2020

IDR

View full text Add to dashboard Cite

In patients with hematologic malignancies due to immune system disorders, especially persistent febrile neutropenia, invasive fungal infections (IFI) occur with high mortality. Aspergillosis, candidiasis, fusariosis, mucormycosis, cryptococcosis and trichosporonosis are the most important infections reported in patients with hematologic malignancies that undergo hematopoietic stem cell transplantation. These infections are caused by opportunistic fungal pathogens that do not cause severe issues in healthy individuals, but in patients with hematologic malignancies lead to disseminated infection with different clinical manifestations. Prophylaxis and creating a safe environment with proper filters and air pressure for patients to avoid contact with the pathogens in the surrounding environment can prevent IFI. Furthermore, due to the absence of specific symptoms in IFI, rapid and accurate diagnosis reduces the mortality rate of these infections and using molecular techniques along with standard mycological methods will improve the diagnosis of disseminated fungal infection in patients with hematologic disorders. Amphotericin B products, extended-spectrum azoles, and echinocandins are the essential drugs to control invasive fungal infections in patients with hematologic malignancies, and according to various conditions of patients, different results of treatment with these drugs have been reported in different studies. On the other hand, drug resistance in recent years has led to therapeutic failures and deaths in patients with blood malignancies, which indicates the need for antifungal susceptibility tests to use appropriate therapies. Life-threatening fungal infections have become more prevalent in patients with hematologic malignancies in recent years due to the emergence of new risk factors, new species, and increased drug resistance. Therefore, in this review, we discuss the different dimensions of the most critical invasive fungal infections in patients with hematologic malignancies and present a list of these infections with different clinical manifestations, treatment, and outcomes.

show abstract

Voriconazole

2021

Reactions Weekly

View full text Add to dashboard Cite

Fatal Disseminated Infection by Trichosporon asahii Under Voriconazole Therapy in a Patient with Acute Myeloid Leukemia: A Review of Breakthrough Infections by Trichosporon spp.

Cited by 19 publications

References 35 publications

A rare case of cutaneous Trichosporon asahii infection in an immunocompromised child

A rare case of cutaneous Trichosporon asahii infection in an immunocompromised child

<p>An Overview of the Management of the Most Important Invasive Fungal Infections in Patients with Blood Malignancies</p>

Voriconazole

Contact Info

Product

Resources

About