Fatal Disseminated BCG Infection

Passwell, J H

doi:10.1001/archpedi.1976.02120050091018

Am J Dis Child

1976

DOI: 10.1001/archpedi.1976.02120050091018

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Fatal Disseminated BCG Infection

J H Passwell¹

Abstract: A 2-year-old boy had a fatal disseminated BCG infection. Immunologic assessment showed a normal humoral response and normal numbers of E rosettes, normal thymus weight and histological features, but an abnormal response of lymphocytes in vitro and negative skin tests. Histological examination showed the presence of Gram-negative acid-fast bacilli within the macrophages. The possible mechanisms of immunodeficiency in this patient are discussed.

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Cited by 20 publications

(1 citation statement)

References 17 publications

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“…The principal genetic difference between the two organisms is that BCG contains several well-defined deletions (4). M. bovis BCG mimics M. tuberculosis in its ability to persist in the body and is also able to cause reactivation disease in the immunocompromised host (1,33,41,43,45,56). Indeed, survival and persistence of the live BCG vaccine are necessary to elicit protective immunity.…”

mentioning

confidence: 99%

Compiling a Molecular Inventory for Mycobacterium bovis BCG at Two Growth Rates: Evidence for Growth Rate-Mediated Regulation of Ribosome Biosynthesis and Lipid Metabolism

Beste

¹

,

Peters

²

,

Hooper

³

et al. 2005

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The principal genetic difference between the two organisms is that BCG contains several well-defined deletions (4). M. bovis BCG mimics M. tuberculosis in its ability to persist in the body and is also able to cause reactivation disease in the immunocompromised host (1,33,41,43,45,56). Indeed, survival and persistence of the live BCG vaccine are necessary to elicit protective immunity.…”

mentioning

confidence: 99%

Compiling a Molecular Inventory for Mycobacterium bovis BCG at Two Growth Rates: Evidence for Growth Rate-Mediated Regulation of Ribosome Biosynthesis and Lipid Metabolism

Beste

¹

,

Peters

²

,

Hooper

³

et al. 2005

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Correlation of Granuloma Structure With Clinical Outcome Defines Two Types of Idiopathic Disseminated BCG Infection

Emile

¹

,

Patey

²

,

Altare

³

et al. 1997

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Disseminated bcg disease associated with immunotherapy by scarification in acute leukemia

Ritch

¹

,

McCredie

²

,

Gutterman

³

et al. 1978

Cancer

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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