Fatal Coronavirus Infection in Puppies following Canine Parvovirus 2b Infection

Pratelli, Annamaria; Tempesta, Maria; Roperto, F.; P, Sagazio; Carmichael, L E; Buonavoglia, Canio

doi:10.1177/104063879901100615

Cited by 57 publications

(54 citation statements)

References 6 publications

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“…The most striking finding of the present study was the detection of an increased mortality rate of dogs suffering from CPV infection that were coinfected with CanineCV. There are previous reports of enhanced susceptibility to viral infections or increased disease severity in CPV-affected dogs coinfected with other pathogens (Appel 1988, Pratelli and others 1999). For example, canine enteric coronavirus (CCoV) infection is regarded as a generally mild, self-limiting infection of the intestinal tract (Tennant and others 1991).…”

Section: Discussionmentioning

confidence: 93%

Role of canine circovirus in dogs with acute haemorrhagic diarrhoea

et al. 2017

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Canine circovirus (CanineCV) has been detected in some dogs with severe haemorrhagic diarrhoea, but its pathogenic role is unclear. This study evaluated a suspected association between the presence of CanineCV and acute haemorrhagic diarrhoea syndrome (AHDS) in dogs. The prevalence of CanineCV in dogs with AHDS was compared with that in healthy dogs and those infected with canine parvovirus (CPV). Additionally, time to recovery and mortality rate were compared between CanineCV-positive and CanineCV-negative dogs. Faecal samples of dogs with AHDS (n=55), healthy dogs (n=66) and dogs infected with CPV (n=54) were examined by two real-time TaqMan PCR assays targeting the replicase and capsid genes of CanineCV. CanineCV was detected in faecal samples of two dogs with AHDS, three healthy controls and seven dogs infected with CPV. Among the three groups, there was no significant difference in prevalence of CanineCV. CPV-infected animals that were coinfected with CanineCV had a significantly higher mortality rate compared with those negative for CanineCV. CanineCV does not appear to be the primary causative agent of AHDS in dogs, but might play a role as a negative co-factor in disease outcome in dogs with CPV infection.

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Section: Discussionmentioning

confidence: 93%

Role of canine circovirus in dogs with acute haemorrhagic diarrhoea

et al. 2017

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“…However, more severe signs can occur, including vomiting, lethargy, haemorrhagic diarrhoea and death (Evermann and others 2005, Buonavoglia and others 2006). Previous reports have linked outbreaks of haemorrhagic diarrhoea to CPV and CECoV co-infection (Pratelli and others 1999b). In diarrhoeic dogs the prevalence of CECoV by RT-PCR has been reported to range from 15 to 42 per cent in pet dogs (Bandai and others 1999, Pratelli and others 2000, Yesilbag and others 2004) and up to 73 per cent in kennelled dogs (Sokolow and others 2005).…”

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confidence: 99%

Epidemiology of canine parvovirus and coronavirus in dogs presented with severe diarrhoea to PDSA PetAid hospitals

Godsall¹,

Clegg

Stavisky

et al. 2010

Veterinary Record

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Canine parvovirus (CPV) and canine enteric coronavirus (CECoV) are often cited as causes of diarrhoea in dogs. This study aimed to determine the prevalence of CPV and CECoV in dogs presenting with severe diarrhoea to PDSA PetAid hospitals throughout the UK. A total of 355 samples were collected from the PDSA between 2006 and 2008. All samples were tested for CPV using a long range PCR and for CECoV using RT-PCR. The prevalence of CPV was 58 per cent (95 per cent confidence interval [CI] 52 to 63 per cent), with some evidence for regional variation. The prevalence of CECoV was 7.9 per cent (95 per cent CI 5.1 to 10.7 per cent). Analysis showed that animals with no history of vaccination were more likely to be CPV positive, with greatest effect in younger animals. CPV-positive animals were more likely to present with depression/lethargy than CPV-negative cases. The volume of diarrhoea and the presence of haemorrhage did not appear to be associated with the likelihood of detecting CPV. This study shows that CPV is a common finding in dogs presenting to PDSA hospitals with severe diarrhoea, and that CECoV is a less common but still potentially important pathogen. It also confirms that young and unvaccinated animals appear to be more at risk of presenting with CPV.

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“…For instance, co-infection by Canine parvovirus (highly related to FPV) has been hypothesized to trigger the pathogenicity of coronavirus in dogs. 20 Many cases of enteritis in cats remain of unknown etiology. In all studies reporting on FAstVs, EM was used to reveal the presence of AstVs.…”

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confidence: 99%

Mixed infection by Feline astrovirus and Feline panleukopenia virus in a domestic cat with gastroenteritis and panleukopenia

et al. 2011

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Abstract. Astroviruses are important pathogens of human beings and animals. Feline astroviruses have been identified by electron microscopy in the feces of either asymptomatic or symptomatic cats, and experimental infection with one isolate was shown to induce enteric clinical signs and virus excretion, thus suggesting a possible role as enteric pathogen. However, due to the lack of specific diagnostic assays, feline astroviruses are not included in the diagnostic algorithms of feline infectious diseases, and their role as feline pathogens remains unclear. The present report describes a dual infection by Feline astrovirus and Feline panleukopenia virus in a 4-month-old cat with severe gastroenteritis and panleukopenia. Upon sequence analysis, the Feline astrovirus strain was found to be genetically related to astroviruses identified in human beings and felids.

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Fatal Coronavirus Infection in Puppies following Canine Parvovirus 2b Infection

Cited by 57 publications

References 6 publications

Role of canine circovirus in dogs with acute haemorrhagic diarrhoea

Role of canine circovirus in dogs with acute haemorrhagic diarrhoea

Epidemiology of canine parvovirus and coronavirus in dogs presented with severe diarrhoea to PDSA PetAid hospitals

Mixed infection by Feline astrovirus and Feline panleukopenia virus in a domestic cat with gastroenteritis and panleukopenia

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