Fatal Case of Lassa Fever, Bangolo District, Côte d’Ivoire, 2015

Mateo, Mathieu; Picard, Caroline; Sylla, Yahaya; Kamo, Emilie; Odegue, Danielle Kpadraux; Journeaux, Alexandra; Kan, Stéphane Kouassi; Money, Marcelle; Coulibaly, David N’golo; Koffi, Eugène; Meite, S; Akran, V.; Kadjo, Hervé A.; Adjogoua, Edgard Valéry; Kakou, Solange N’Gazoa; Baize, Sylvain; Dosso, Mireille

doi:10.3201/eid2509.190239

Cited by 7 publications

(1 citation statement)

References 8 publications

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“…Only the discovery of LASV-positive M. natalensis in southern Mali and then northern Côte d'Ivoire has enabled these sequences to be compared with those observed in the German tourist, suggesting that she was infected in this region rather than in Burkina Faso [ 31 ]. Similarly, the acute case of a forester recently discovered in eastern Côte d'Ivoire was probably acquired far from home, as he was infected by a strain that is phylogenetically close to those observed in Upper Guinea [ 32 ]. The aim of our study was to investigate the LASV spread and circulation in the MRU area by using rodent-derived, whole LASV genome sequences from 27 localities.…”

Section: Introductionmentioning

confidence: 99%

Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa

Bangura,

Davis,

Lamin

et al. 2024

Emerging Microbes & Infections

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The spread of Lassa virus (LASV) in Guinea, Liberia and Sierra Leone, which together are named the Mano River Union (MRU) area, was examined phylogeographically. To provide a reliable evolutionary scenario, new rodent-derived, whole LASV sequences were included. These were generated by metatranscriptomic next-generation sequencing from rodents sampled between 2003 and 2020 in 21 localities of Guinea and Sierra Leone. An analysis was performed using BEAST to perform continuous phylogeographic inference and EvoLaps v36 to visualize spatio-temporal spread. LASV was identified as expected in its primary host reservoir, the Natal multimammate mouse ( Mastomys natalensis ), and also in two Guinean multimammate mice ( Mastomys erythroleucus ) in northern Sierra Leone and two rusty-bellied brush-furred mice ( Lophuromys sikapusi ) in southern Sierra Leone. This finding is consistent with the latter two species being secondary host reservoirs. The strains in these three species were very closely related in LASV lineage IV. Phylogenetic analysis indicated that the most recent common ancestor of lineage IV existed 316–374 years ago and revealed distinct, well-supported clades from Sierra Leone (Bo, Kabala and Kenema), Guinea (Faranah, Kissidougou-Guekedou and Macenta) and Liberia (Phebe-Ganta). The phylogeographic scenario suggests southern Guinea as the point of origin of LASV in the MRU area, with subsequent spread to towards Mali, Liberia and Sierra Leone at a mean speed of 1.6 to 1.1 km/year.

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Section: Introductionmentioning

confidence: 99%