Fatal case of clinically amyopathic dermatomyositis: Cotton‐wool spots as a sign of an aggressive subtype of dermatomyositis

Ito, Akiko; Nakamura, Yusuke; Saito, Kanami; Sho, Yuriko; Ishikawa, Kazushi; Shimada, Hideaki; Hatano, Yutaka; Okamoto, Osamu; Haranaka, Miwa; Ishii, Koji; Nakamuro, Takako; Kimoto, Katsuhiko; Kuwana, Masataka; Hamaguchi, Yasuhito; Fujiwara, Sakuhei

doi:10.1111/1346-8138.12618

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…However, when the retina is affected visual prognosis is often poor with an irreversible visual loss [14]. The presence of retinopathy with CWS has also been suggested as a sign of an aggressive subtype of DM [6].…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography angiography in Purtscher-like retinopathy associated with dermatomyositis: a case report

et al. 2019

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Purpose To describe a multimodal imaging diagnosis of retinopathy in dermatomyositis. Case presentation A 21-year-old white woman with a history of fatigue and a cutaneous rash complained of visual impairment in her left eye. A funduscopic examination showed multiple confluent cotton-wool spots in both eyes. Swept source-optical coherence tomography presented macular edema in both eyes; optical coherence tomography angiography revealed superficial and deep capillary occlusion in all areas affected by cotton-wool spots; and fluorescein angiography showed vascular walls enhancement, veins dilatation, and capillary leakage. After large doses of intravenously administered glucocorticoid therapy, followed by a cyclophosphamide regimen, best corrected visual acuity returned to 20/20 in both eyes. Conclusions This case report presents optical coherence tomography angiography clinical findings in a rare case of dermatomyositis-associated retinopathy, remarking the importance of a multi-imaging approach for a correct diagnosis and treatment of eye injuries, in order to avoid serious complications and permanent sequelae.

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Section: Introductionmentioning

confidence: 99%

Optical coherence tomography angiography in Purtscher-like retinopathy associated with dermatomyositis: a case report

et al. 2019

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“…[46] Pamuk yünü lekeli retinopati varlığı da Dermatomiyozitin agresif seyrinin işareti olabileceği şeklinde öne sürülmüştür. [47] Tedavi seçenekleri, sistemik kortikosteroidler ve diğer immünosupresif ajanları içerir ve genellikle optik disk ödemi ve göz içi inflamasyonun başarılı bir şekilde çözülmesiyle sonuçlanır, nadiren göz içi tedavi gerektirir. [48]…”

Section: Poliarteritis Nodozaunclassified

Autoimmune Diseases and Retina

2023

Güncel Retina (Current Retina)

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Autoimmune diseases are a group of diseases that can result in organ-specific and/or systemic (systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis,...) anatomical deformation and loss of function as a result of the body's immune system attacking its own antigens under the influence of genetic and environmental factors. The eye is a potential target for complications related to autoimmunity, and depending on the severity of the immune response, vision-threatening problems can be observed. Immune complexes accumulate in and around the vessel walls as a result of humoral immunity, in which the autoantibody-related complement system is activated, and cellular immune response can lead to retinal vasculitis, vaso-occlusion, retinal hemorrhage, retinal ischemia, ischemic optic neuropathy, and inflammation of periorbital tissues. Therefore, the role of ophthalmologists in disease management is important in diagnosing, investigating, and treating ocular symptoms in a timely manner. Early diagnosis and treatment can play a critical role to decrease the risk of irreversible immunological damage to the retinal tissue. A multi-disciplinary approach for complete management and evaluation is needed in this disease group. This study aimed to provide a detailed review of the current clinical perspective for the diagnosis, workup, and treatment of autoimmune diseases with retinal manifestations. Systemic lupus erythematosus, Polyarteritis Nodosa, Dermatomyositis, Scleroderma, Wegener's Granulomatosis, Churg-Strauss Syndrome, Takayasu Arteritis, Susac Syndrome, and Nodular Panniculitis are discussed under this heading.

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Fatal case of clinically amyopathic dermatomyositis: Cotton‐wool spots as a sign of an aggressive subtype of dermatomyositis

Cited by 2 publications

References 5 publications

Optical coherence tomography angiography in Purtscher-like retinopathy associated with dermatomyositis: a case report

Optical coherence tomography angiography in Purtscher-like retinopathy associated with dermatomyositis: a case report

Autoimmune Diseases and Retina

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