Fatal cardiac arrhythmia following voluntary caffeine overdose in an amateur body-builder athlete

Poussel, Mathias; Kimmoun, Antoine; Lévy, Bruno; Gambier, Nicolas; Dudek, Frederic; Puskarczyk, Emmanuel; Poussel, J.F.; Chenuel, Bruno

doi:10.1016/j.ijcard.2013.01.238

Cited by 31 publications

(16 citation statements)

References 8 publications

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“…Death from caffeine poisoning, although rare, does occur. The direct cause of death is generally attributed to ventricular dysrhythmia, though caffeine cardiovascular effects are not limited to arrhythmogenesis [5,11,18].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the risk of intentionally or unintentionally ingesting potentially lethal levels of caffeine has been heightened by its easy availability. Indeed, energy drinks and shots with high caffeine content are readily found in shops and health stores and pure caffeine anhydrous and anorecting tablets can be purchased online [16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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A case of suicide by ingestion of caffeine

Bonsignore

Sblano

Pozzi

et al. 2014

Forensic Sci Med Pathol

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Intentional or unintentional caffeine abuse due to excessive intake of beverages or energy drinks containing caffeine is relatively frequent. However, death due to caffeine intoxication is rare and case reports of fatalities from caffeine toxicity are relatively infrequent. In this report, we describe an autopsy case involving a 31 year-old man who intentionally took a large amount of caffeine tablets in the form of a weight loss supplement as part of a suicide plan. Caffeine femoral blood concentration (170 mg/l) was within the toxic and potentially lethal ranges reported in the literature in similar cases. Postmortem biochemistry results suggested depressed glomerular filtration rate and pre-renal failure at the time of death but failed to reveal myoglobinuria, glycosuria, ketonuria or ketonemia. Based on the absence of pathological findings at autopsy and the high blood caffeine level, death was attributed to acute caffeine toxicity. The case emphasizes the usefulness of performing exhaustive toxicology and searching for all potentially relevant information in order to formulate appropriate hypotheses concerning the cause and manner of death.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A case of suicide by ingestion of caffeine

Bonsignore

Sblano

Pozzi

et al. 2014

Forensic Sci Med Pathol

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“…Eine Übersichtstabelle findet sich bei [9]. Fatale Intoxikationenoft in suizidaler Absichtwurden insbesondere nach Ingestion von Koffeintabletten oder von reinem Koffeinextrakt in Pulverform ("caffeine anhydrous") [10,11] beschrieben.…”

Section: Anamnese Und Klinische Präsentationunclassified

Schwere akzidentelle Intoxikation durch Koffeinextrakt

Wellershoff

2018

Notarzt

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“…Caffeine alone is not suspected to induce any ECG changes in healthy volunteers at a dose of 400 mg . Typically, caffeine toxicity–related adverse events have only been observed in case studies where doses far exceed 400 mg …”

Section: Introductionmentioning

confidence: 99%

Randomized Controlled Trial of High‐Volume Energy Drink Versus Caffeine Consumption on ECG and Hemodynamic Parameters

Fletcher

Lacey

Aaron

et al. 2017

JAHA

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BackgroundCaffeine in doses <400 mg is typically not considered arrhythmogenic, but little is known about the additional ingredients in energy drinks. We evaluated the ECG and blood pressure (BP) effects of high‐volume energy drink consumption compared with caffeine alone.Methods and ResultsThis was a randomized, double‐blind, controlled, crossover study in 18 young, healthy volunteers. Participants consumed either 946 mL (32 ounces) of energy drink or caffeinated control drink, both of which contained 320 mg of caffeine, separated by a 6‐day washout period. ECG, peripheral BP, and central BP measurements were obtained at baseline and 1, 2, 4, 6, and 24 hours post study drink consumption. The time‐matched, baseline‐adjusted changes were compared. The change in corrected QT interval from baseline in the energy drink arm was significantly higher than the caffeine arm at 2 hours (0.44±18.4 ms versus −10.4±14.8 ms, respectively; P=0.02). The QTc changes were not different at other time points. While both the energy drink and caffeine arms raised systolic BP in a similar fashion initially, the systolic BP was significantly higher at 6 hours when compared with the caffeine arm (4.72±4.67 mm Hg versus 0.83±6.09 mm Hg, respectively; P=0.01). Heart rate, diastolic BP, central systolic BP, and central diastolic BP showed no evidence of a difference between groups at any time point. Post energy drink, augmentation index was lower at 6 hours.ConclusionsThe corrected QT interval and systolic BP were significantly higher post high‐volume energy drink consumption when compared with caffeine alone. Larger clinical trials validating these findings and evaluation of noncaffeine ingredients within energy drinks are warranted.Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT02023723.

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Fatal cardiac arrhythmia following voluntary caffeine overdose in an amateur body-builder athlete

Cited by 31 publications

References 8 publications

A case of suicide by ingestion of caffeine

A case of suicide by ingestion of caffeine

Schwere akzidentelle Intoxikation durch Koffeinextrakt

Randomized Controlled Trial of High‐Volume Energy Drink Versus Caffeine Consumption on ECG and Hemodynamic Parameters

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