Fatal attraction: The roles of ribosomal proteins in the viral life cycle

Miller, Clare M.; Selvam, Sangeetha; Fuchs, Gabriele

doi:10.1002/wrna.1613

Cited by 16 publications

(9 citation statements)

References 150 publications

(210 reference statements)

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“…In addition, we observed that host proteins that are targeted by M protein form a PPI network centered on ribosomal proteins. As we all know, the function of the ribosome is mainly responsible for translation regulation within the host, and many researchers have found that ribosomes play an indispensable role in the life cycle of viruses (Li, 2019;Miller et al, 2021). Therefore, we speculated that SADS-CoV M protein may create conditions for viral translation by targeting ribosomal proteins in the host, which deserve further studies.…”

Section: Discussionmentioning

confidence: 91%

“…At present, more and more researchers pay attention to the relationship between the ribosome and the virus. Ribosomal proteins play an important role in the life cycle of viruses, such as promoting virus translation, participating in virus assembly and replication, and acting as virus receptors (Li, 2019;Dong et al, 2021;Miller et al, 2021). RPL18 belongs to the ribosomal 60s subunit, and some studies have shown that it is involved in ribosome assembly.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of Interaction Network Between Host Protein and M Protein of Swine Acute Diarrhea Syndrome Coronavirus

Cao

et al. 2022

Front. Microbiol.

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Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an enterovirus that can cause acute diarrhea and death in piglets and cause serious economic losses to the pig industry. SADS-CoV membrane (M) protein mainly plays a key role in biological processes, such as virus assembly, budding, and host innate immune regulation. Understanding the interaction between M protein and host proteins is very important to define the molecular mechanism of cells at the protein level and to understand specific cellular physiological pathways. In this study, 289 host proteins interacting with M protein were identified by glutathione-S-transferase (GST) pull-down combined with liquid chromatography-mass spectrometry (LC-MS/MS), and the protein-protein interaction (PPI) network was established by Gene Ontology (GO) terms and Kyoto Encyclopedia of Gene and Genomes (KEGG) pathways analysis. Results showed that SADS-CoV M protein was mainly associated with the host metabolism, signal transduction, and innate immunity. The Co-Immunoprecipitation (CO-IP) validation results of six randomly selected proteins, namely, Rab11b, voltage-dependent anion-selective channel 1 (VDAC1), Ribosomal Protein L18 (RPL18), RALY, Ras Homolog Family Member A (RHOA), and Annexin A2 (ANXA2), were consistent with LC-MS results. In addition, overexpression of RPL18 and PHOA significantly promoted SADS-CoV replication, while overexpression of RALY antagonized viral replication. This work will help to clarify the function of SADS-CoV M protein in the life cycle of SADS-CoV.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Analysis of Interaction Network Between Host Protein and M Protein of Swine Acute Diarrhea Syndrome Coronavirus

Cao

et al. 2022

Front. Microbiol.

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“…rRNAs are the main effectors of ribosome dynamics during mRNA decoding, peptide bond formation, and translation ( Erales et al, 2017 ). In addition to being components of ribosomes, RPs play an important role in ribosome biogenesis, and they regulate many fundamental life processes, including cell cycle, cell proliferation, apoptosis, tumor development, genome integrity and development, and so on ( Li, 2019 ; Miller et al, 2021 ).…”

Section: Viruses Hijack Ribosomes To Complete Viral Protein Translationmentioning

confidence: 99%

Ribosomal control in RNA virus-infected cells

et al. 2022

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Viruses are strictly intracellular parasites requiring host cellular functions to complete their reproduction cycle involving virus infection of host cell, viral genome replication, viral protein translation, and virion release. Ribosomes are protein synthesis factories in cells, and viruses need to manipulate ribosomes to complete their protein synthesis. Viruses use translation initiation factors through their own RNA structures or cap structures, thereby inducing ribosomes to synthesize viral proteins. Viruses also affect ribosome production and the assembly of mature ribosomes, and regulate the recognition of mRNA by ribosomes, thereby promoting viral protein synthesis and inhibiting the synthesis of host antiviral immune proteins. Here, we review the remarkable mechanisms used by RNA viruses to regulate ribosomes, in particular, the mechanisms by which RNA viruses induce the formation of specific heterogeneous ribosomes required for viral protein translation. This review provides valuable insights into the control of viral infection and diseases from the perspective of viral protein synthesis.

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“…EBV has a complex life cycle, showing different cellular tropisms depending on the stage of infection. At least five different stages have been described as being part of the viral life cycle: lytic infection, latency III, latency II, latency I/0, and lytic reactivation [108][109][110].…”

Section: Epstein-barr Virus (Ebv)mentioning

confidence: 99%

Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis

2021

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Tumorigenesis due to viral infection accounts for a high fraction of the total global cancer burden (15–20%) of all human cancers. A comprehensive understanding of the mechanisms by which viral infection leads to tumor development is extremely important. One of the main mechanisms by which viruses induce host cell proliferation programs is through controlling the host’s epigenetic machinery. In this review, we dissect the epigenetic pathways through which oncogenic viruses can integrate their genome into host cell chromosomes and lead to tumor progression. In addition, we highlight the potential use of drugs based on histone modifiers in reducing the global impact of cancer development due to viral infection.

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Fatal attraction: The roles of ribosomal proteins in the viral life cycle

Cited by 16 publications

References 150 publications

Analysis of Interaction Network Between Host Protein and M Protein of Swine Acute Diarrhea Syndrome Coronavirus

Analysis of Interaction Network Between Host Protein and M Protein of Swine Acute Diarrhea Syndrome Coronavirus

Ribosomal control in RNA virus-infected cells

Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis

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