Fatal anticonvulsant hypersensitivity syndrome in an infant

Phenobarbitone Causing Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in a Child Previously Exposed to Long-Term Phenobarbitone as an Infant

“…Another 3 month old infant who developed DRESS 2 weeks after starting Phenobarbitone subsequently died. In contrast, all her viral serologies, including HHV-6, were negative [4]. Hence although there may be a role of HHV-6 reactivation, leading to DRESS [5], it is clearly not the only pathomechanism as our patient had a negative HHV-6 serology.…”