Fatal aluminium phosphide poisoning

Meena, Mahesh Chand; Mittal, Sachin; Rani, Yashoda

doi:10.1515/intox-2015-0010

Cited by 22 publications

(9 citation statements)

References 9 publications

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“…The incidence of ALP poisoning increased steadily specially in developing countries (Meena et al, 2015).To the greatest extent, most reports of aluminum phosphide poisoning were suicidal especially in young adult, although accidental poisoning may occur during occupational exposure (Hosseinian et al, 2011;Chaudhary et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Predictive Factors of Mortality in Acute Aluminum Phosphide Poisoning: 5 Years Retrospective Study in Tanta Poison Control Unit

El-Sarnagawy

2017

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Introduction: Aluminum phosphide (ALP) is a widely used rodenticide for grain preservation. Acute aluminum phosphide poisoning became one of the serious public health problems especially in developing countries due to its high mortality rates. Aim of the work: The aim of the present study was to evaluate the predictive factors of mortality from acute ALP poisoned cases admitted to Tanta Poison Control Unit in a 5 years interval from the start of January 2012 to the end of December 2016. Patients and methods: This retrospective study was performed on medical records of acute ALP poisoned patients admitted to Tanta Poison Control Unit during the 5 years period. Patients were divided according to their outcome into survivors and non-survivors. For all patients; sociodemographic data, toxicological data, physical examination, laboratory investigation and therapeutic intervention were recorded to evaluate their associations with the patients' outcome. Results: During the five years period, 105 acute ALP poisoned patients were admitted with 44.7% deaths. There was significant association between each of young age group, rural residence, suicidal ingestion, increase toxic dose and prehospitalization period with the risk of mortality. Other prognostic factors included altered consciousness, agitations, hypokalemia, hypernatremia, hyperglycemia, elevated (liver enzymes, blood urea& serum creatinine), need of mechanical ventilation, increased vasoactive drug administration and low magnesium sulphate administration were also associated with poor outcome. Moreover, presence of abnormal ECG, metabolic acidosis and low systolic blood pressure at admission were associated with high risk of mortality (odd ratios were 48.488, 10.251 and 0.964 respectively). Conclusion: Early recognition of the alarming risk factors with proper medical intervention may improve patients' outcome and decrease the mortality rate of acute aluminum phosphide poisoning. Recommendations: Owing to the increase mortality rates of ALP poisoning, it is recommended to make restrictions of its open sales and perform a safe manufacture forms in a not ingestible containers.

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Section: Introductionmentioning

confidence: 99%

Predictive Factors of Mortality in Acute Aluminum Phosphide Poisoning: 5 Years Retrospective Study in Tanta Poison Control Unit

El-Sarnagawy

2017

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…ALP is available as a dark-grey 3g-tablet most commonly in the name of Celphos in Nepal. ALP is fatal with a mortality rate of 37% to 100% [4,5]. The lethal dose of ALP is 1-1.5g and even a dose of 150-500mg have resulted in mortality [5].…”

Section: Discussionmentioning

confidence: 99%

A case of Aluminum Phosphide poisoning managed successfully in Nepal: A Case Report

Jha¹,

Basnet²,

Chaulagain³

et al. 2022

Iberoam J Med

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Aluminum phosphide (ALP) is a highly toxic compound most commonly available as Celphos in Nepal. Suicidal ingestion is common in developing countries like Nepal as it is easily available and has a high mortality rate. Farmers to protect crops from rodents and pests use it. Here we present a case of a 24-year-old female with suicidal ingestion of one and a half-tablet of ALP presented with abdominal pain and vomiting. The patient developed metabolic acidosis, hyperkalemia, acute respiratory distress, and hypotension during the Intensive Care Unit stay. Supportive treatment with gastric lavage (coconut oil), intravenous magnesium sulfate, sodium-bicarbonate infusion, adequate vasopressor and close monitoring of hemodynamic parameters helped in the survival of the patient.

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“…Phenol is considered to be extremely harmful and toxic to human health owing to its rapid absorption through the lungs and its distribution in the body [18]. The average fatal dose is approximately 25-50 mL of household phenol [19]. Sensitivity and selective analytical methods such as spectrophotometry [20], gas and liquid chromatography [21], capillary electrophoresis [22] and flow injection analysis [23] are widely used for monitoring phenol.…”

Section: Introductionmentioning

confidence: 99%

Multiwalled Carbon Nanotubes/4,4′‐Dihydroxybiphenyl Nanolayered Composite for Voltammetric Detection of Phenol

et al. 2021

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This paper reports the preparation of multiwalled carbon nanotubes/4,4′‐dihydroxybiphenyl (MWCNTs‐DHB) nanolayered composite as a new modifier for modification of carbon paste electrode (CPE/MWCNTs‐DHB). CPE/MWCNTs‐DHB shows linear responses for phenol in the concentrations range of 0.04–220 μM with a current sensitivity of 0.67 μA μM−1 and a detection limit of 8.0 nM (S/N=3). The electrode shows high selectivity, good repeatability (RSD=4.1 %), excellent reproducibility (RSD=3.5 %), and acceptable stability (91.2 % over one‐month storage). Moreover, the modified CPE exhibits appreciable recoveries (93.0–104.0 %) indicating its acceptable performance for determination of phenol in tap and river water samples.

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Fatal aluminium phosphide poisoning

Cited by 22 publications

References 9 publications

Predictive Factors of Mortality in Acute Aluminum Phosphide Poisoning: 5 Years Retrospective Study in Tanta Poison Control Unit

Predictive Factors of Mortality in Acute Aluminum Phosphide Poisoning: 5 Years Retrospective Study in Tanta Poison Control Unit

A case of Aluminum Phosphide poisoning managed successfully in Nepal: A Case Report

Multiwalled Carbon Nanotubes/4,4′‐Dihydroxybiphenyl Nanolayered Composite for Voltammetric Detection of Phenol

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