Fat tissue morphology of long-term sex steroid deficiency and estrogen treatment in female rats

Carlos, Aluana Santana; Costa, Carlos Alberto Soares da; Armada, Luciana; Gonzalez, Gabrielle de Paula Lopes; Ribeiro, Mariana da Silva; Santos, Ana Sílvia Pereira; Carvalho, Jorge José de; Saba, Celly Cristina Alves do Nascimento

doi:10.1016/j.fertnstert.2011.01.020

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…In this study, the modifying effect of 0.3% PM on mammary gland and uterus was comparable with that of 0.2% IA. In the medium and especially high dose PM groups, decreases of rat body weights, adipose deposition, and total cholesterol and triglycerides levels in the blood were obvious, which was likely due to antilipogenic effects of estrogenic compounds described previously, or due to the decrease of water intakes of rats by PM [16]. In the long-term experiment, we observed the significant increase of mammary adenocarcinoma development induced by PM at a dose of 0.3%.…”

Section: Discussionsupporting

confidence: 68%

Pueraria <em>mirifica</em> Exerts Estrogenic Effect and Promotes Mammary and Endometrial

Kakehashi

Yoshida

Tago

et al. 2016

Preprint

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Pueraria mirifica (PM) is a plant which dried and powdered tuberous root is now widely used as a rejuvenating herb to promote youthfulness in both men and women. In this study, we investigated the modifying effects of PM at various doses on mammary and endometrial carcinogenesis in female Donryu rats. Firstly, PM administered to ovariectomized Donryu rats at doses of 0.03, 0.3 and 3% in phytoestrogen-low diet for 2 weeks induced the significant increases of uterus weight. Secondly, 4-week PM application to non-operated rats at a dose of 3% after the 7,12-dimethylbenz[a]anthracene (DMBA) initiation, resulted in significant elevation of cell proliferation in the mammary glands. In the third experiment, postpubertal administration of 0.3% (200 mg/kg b.w./day) PM to 5-week-old non-operated animals for 36 weeks following the initiation of mammary and endometrial carcinogenesis with DMBA and N-ethyl-N′-nitro-N-nitrosoguanidine (ENNG), respectively, caused significant increases of mammary adenocarcinoma incidence and multiplicity. A trend for increase of uterine adenocarcinomas and a significant increase of endometrial atypical hyperplasia multiplicity was observed at 0.3% PM. Furthermore, PM at doses of 0.3 and mostly 1% induced dilatation, hemorrhage and inflammation of the uterine wall. In conclusion, the postpubertal long-term PM administration to Donryu rats exerted estrogenic effect in the mammary gland and uterus, and at a dose of 200 mg/kg b.w./day promoted carcinogenesis initiated by DMBA and ENNG.

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Section: Discussionsupporting

confidence: 68%

Pueraria <em>mirifica</em> Exerts Estrogenic Effect and Promotes Mammary and Endometrial

Kakehashi

Yoshida

Tago

et al. 2016

Preprint

View full text Add to dashboard Cite

show abstract

“…In this study, the modifying effects of 0.3% PM on mammary gland and uterus were comparable with those of 0.2% IA. In the medium and especially in the high dose PM groups, decreases of rat body weights, adipose deposition, and total cholesterol and triglyceride levels in the blood were obvious, likely due to antilipogenic effects of estrogenic compounds described previously, or perhaps to the decrease of water intake of rats given PM [16]. In the long-term experiment, we observed significant increase of mammary adenocarcinoma development induced by PM at a dose of 0.3%.…”

Section: Discussionsupporting

confidence: 67%

Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats

Kakehashi

Yoshida

Tago

et al. 2016

Toxins

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Pueraria mirifica (PM), a plant whose dried and powdered tuberous roots are now widely used in rejuvenating preparations to promote youthfulness in both men and women, may have major estrogenic influence. In this study, we investigated modifying effects of PM at various doses on mammary and endometrial carcinogenesis in female Donryu rats. Firstly, PM administered to ovariectomized animals at doses of 0.03%, 0.3%, and 3% in a phytoestrogen-low diet for 2 weeks caused significant increase in uterus weight. Secondly, a 4 week PM application to non-operated rats at a dose of 3% after 7,12-dimethylbenz[a]anthracene (DMBA) initiation resulted in significant elevation of cell proliferation in the mammary glands. In a third experiment, postpubertal administration of 0.3% (200 mg/kg body weight (b.w.)/day) PM to 5-week-old non-operated animals for 36 weeks following initiation of mammary and endometrial carcinogenesis with DMBA and N-ethyl-N′-nitro-N-nitrosoguanidine (ENNG), respectively, resulted in significant increase of mammary adenocarcinoma incidence. A significant increase of endometrial atypical hyperplasia multiplicity was also observed. Furthermore, PM at doses of 0.3%, and more pronouncedly, at 1% induced dilatation, hemorrhage and inflammation of the uterine wall. In conclusion, postpubertal long-term PM administration to Donryu rats exerts estrogenic effects in the mammary gland and uterus, and at a dose of 200 mg/kg b.w./day was found to promote mammary carcinogenesis initiated by DMBA.

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Flaxseed flour diet during lactation until 180 days results in an increase in body adiposity in adult male rats

Abreu

Pessoa

Costa

et al. 2017

Journal of Functional Foods

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Fat tissue morphology of long-term sex steroid deficiency and estrogen treatment in female rats

Cited by 4 publications

References 26 publications

Pueraria <em>mirifica</em> Exerts Estrogenic Effect and Promotes Mammary and Endometrial

Pueraria <em>mirifica</em> Exerts Estrogenic Effect and Promotes Mammary and Endometrial

Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats

Flaxseed flour diet during lactation until 180 days results in an increase in body adiposity in adult male rats

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