Fat-soluble vitamins A and E and health disparities in a cohort of pregnant women at delivery

Hanson, Corrine; Schumacher, Marina Verdi; Lyden, Elizabeth; Su, Dejun; Furtado, Jeremy D.; Cammack, Rex G.; Bereitschaft, Bradley; Ormer, Matthew Van; Needelman, Howard; McGinn, Elizabeth; Rilett, Katherine; Cave, Caleb; Johnson, Rebecca L.; Weishaar, Kara; Anderson‐Berry, Ann

doi:10.1017/jns.2018.5

Cited by 11 publications

(21 citation statements)

References 54 publications

(55 reference statements)

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“…Although the original study addressed the effects of bariatric surgery on serum vitamin A levels during pregnancy, the most surprising result was that more than 60% of the pregnant women who did not undergo the bariatric surgery (control group) had serum retinol levels during the third-trimester lower than 1.05 µmol/l [16], meeting the criteria for vitamin A de ciency. This proportion of vitamin A de cient women in the Bronx was much higher than that of non-White women of the same age group recently reported by Hanson et al [19]. As Hispanics (56%) and non-Hispanic Black (29%) are the major race and ethnic groups in the Bronx [18], our ndings [16] prompted us to re-analyze the disproportionality of VAD status in the Hispanic and non-Hispanic Black pregnant women from the Bronx study.…”

Section: Main Textcontrasting

confidence: 57%

Disproportionate vitamin A deficiency in pregnant women of specific ethnicities in the United States and ethnic differences in allele frequencies of polymorphisms of vitamin A-related genes

Suzuki

Wang

Garretto

et al. 2021

Preprint

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BackgroundVitamin A is an essential micronutrient that plays critical roles in many biological functions of the body. The current national prevalence rate of vitamin A deficiency (VAD) in the United States is reported to be very low (<1%). However, our recent study in an urban city of the U. S. (the Bronx study) revealed that pregnant women in the Bronx have much higher proportions of VAD than the national prevalence rate. Given that Hispanics (56%) and non-Hispanic Blacks (29%) are the major racial and ethnic groups in the Bronx, we hypothesized that VAD could be more prevalent among pregnant women from specific ethnicities in the U.S. We therefore re-analyzed two independent datasets of serum retinol levels, i.e., the data from the the Bronx study and the National Health and Nutrition Examination Survey (NHANES). Moreover, as known polymorphisms have been associated with vitamin A status, we also assessed the differences of minor allele frequencies of these polymorphisms between ethnic groups in publicly available datasets, such as the Allele Frequency Aggregator (ALFA), the Population Architecture using Genomics and Epidemiology (PAGE), and the 1000 Genomes project. FindingsWe found that in both datasets of pregnant women non-Hispanic Black and Hispanic ethnicities have high proportions of VAD compared to non-Hispanic White pregnant women, and this VAD prevalence rate was much higher of the currently estimated national prevalence level. Interestingly, non-Hispanic Black pregnant women showed comparably high proportions of VAD in both datasets. However, pregnant women with Latin American/Afro-Caribbean ancestry in the Bronx dataset have strikingly high proportion of VAD compared to Latin American/Mexican ancestry in NHANES dataset (p= 1.973e-10, 95%CI 0.04 - 0.22, Fisher’s exact test). Furthermore, from the ALFA and the PAGE data analysis, we showed that the known single nucleotide polymorphism (SNP) located near the RBP4 gene (rs10882272) associated with lower serum retinol levels occurs at higher frequencies in Latin American/Afro-Caribbean ancestry and non-Hispanic Black/African populations compared to Latin American/Mexican ancestry and European populations. In addition, the analysis of minor allele frequency (MAF) of 39 previously reported SNPs associated with vitamin A metabolism showed significantly higher MAF variations between populations of different ancestries than that of randomly selected SNPs (p=0.030, permutation test with 1,000 iterations). ConclusionsWe confirmed that VAD rates in the pregnant women differ between different ethnicities, and that pregnant women in minority groups in the U.S. have much higher VAD rates than the estimated national prevalence level. Moreover, our analysis suggested that ethnic differences in allele frequencies of polymorphisms of vitamin A-related genes might contribute to the observed VAD rate differences. Further genome-wide association studies are needed to assess the influences of specific genetic variation and the different VAD status between different ethnic groups.

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Section: Main Textcontrasting

confidence: 57%

Disproportionate vitamin A deficiency in pregnant women of specific ethnicities in the United States and ethnic differences in allele frequencies of polymorphisms of vitamin A-related genes

Suzuki

Wang

Garretto

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Although the original study addressed the effects of bariatric surgery on serum vitamin A levels during pregnancy, the most surprising result was that more than 60% of the pregnant women who did not undergo the bariatric surgery (the control group) had serum retinol levels during the third-trimester lower than 1.05 µmol/L [ 16 ], meeting the criteria for vitamin A deficiency. This proportion of vitamin A deficient women in the Bronx was much higher than that of non-White women (Hispanic/Latino, non-Hispanic Black and other race/ethnicity than non-Hispanic White) of the same age group in the U.S. recently reported by Hanson et al [ 19 ]. In the study, the authors recruited Hispanic/Latino, non-Hispanic White, non-Hispanic Black, and other race/ethnicity (including multiracial) pregnant women to their study from the Labor and Delivery unit in a Midwestern United States Academic Medical Center, which is located in suburban Chicago, IL, USA, where Latin Americans with Mexican ancestry are the majority group of Hispanics/Latinos.…”

Section: Introductionmentioning

confidence: 73%

Disproportionate Vitamin A Deficiency in Women of Specific Ethnicities Linked to Differences in Allele Frequencies of Vitamin A-Related Polymorphisms

et al. 2021

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Background: While the current national prevalence rate of vitamin A deficiency (VAD) is estimated to be less than 1%, it is suggested that it varies between different ethnic groups and races within the U.S. We assessed the prevalence of VAD in pregnant women of different ethnic groups and tested these prevalence rates for associations with the vitamin A-related single nucleotide polymorphism (SNP) allele frequencies in each ethnic group. Methods: We analyzed two independent datasets of serum retinol levels with self-reported ethnicities and the differences of allele frequencies of the SNPs associated with vitamin A metabolism between groups in publicly available datasets. Results: Non-Hispanic Black and Hispanic pregnant women showed high VAD prevalence in both datasets. Interestingly, the VAD prevalence for Hispanic pregnant women significantly differed between datasets (p = 1.973 × 10−10, 95%CI 0.04–0.22). Alleles known to confer the risk of low serum retinol (rs10882272 C and rs738409 G) showed higher frequencies in the race/ethnicity groups with more VAD. Moreover, minor allele frequencies of a set of 39 previously reported SNPs associated with vitamin A metabolism were significantly different between the populations of different ancestries than those of randomly selected SNPs (p = 0.030). Conclusions: Our analysis confirmed that VAD prevalence varies between different ethnic groups/races and may be causally associated with genetic variants conferring risk for low retinol levels. Assessing genetic variant information prior to performing an effective nutrient supplementation program will help us plan more effective food-based interventions.

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“…In accordance with other investigations, age (⩾29 years) and income-to-poverty ratio were dichotomized at the median value. 22 BMI was also included and categorized as underweight (BMI < 18.5), normal (BMI 18.5–24.9), overweight (BMI 25–29.9), obese class I (BMI 30–34.9), obese class II (BMI 35–39.9), and obese class III (BMI 40 or greater). 23…”

Section: Methodsmentioning

confidence: 99%

The impact of body mass index and sociodemographic factors on moderate-to-vigorous physical activity and sedentary behaviors of women with young children: A cross-sectional examination

Dinkel

Hein

Snyder

et al. 2020

Womens Health (Lond Engl)

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Objectives: Moderate-to-vigorous physical activity provides multiple benefits to women after childbirth. To achieve these benefits, the recommendation that adults obtain, 150 min of moderate-to-vigorous physical activity per week and reduce sedentary behaviors, also applies to women in the post-partum phase of the life span. However, research examining the moderate-to-vigorous physical activity and sedentary behaviors of women with young children (0–2 years) is limited. A greater understanding of these behaviors from a nationally representative sample is needed. Therefore, the primary objective of this study was to determine the levels of moderate-to-vigorous physical activity and sedentary behaviors of a nationally representative sample of women with young children within the United States. A secondary objective was to examine the influence of body mass index and sociodemographic factors on these behaviors. Methods: Cross-sectional data from four cycles of the National Health and Nutrition Examination Survey (2007–2008, 2009–2010, 2011–2012, and 2013–2014) were used for analysis. Descriptive statistics were calculated and a generalized linear model was used to investigate associations between mean minutes of moderate-to-vigorous physical activity, sedentary activity, body mass index, and sociodemographic variables. Discussion: Women with young children (n = 477) obtained 634 min in moderate-to-vigorous physical activity per week and this was positively associated with having a higher income (p < 0.001) and the number of children in the home (p < 0.001). In total, 62% of women were meeting the World Health Organization guidelines for aerobic activity. Lower odds of achieving guidelines was associated with being Black (p = 0.004), Mexican American (p = 0.009), or married (p = 0.042) compared with being White or not married. Finally, women accumulated ~5 h of sedentary activity per day, with higher levels associated with race (p = 0.005), education (p = 0.022), and number of children within the home (p < 0.001). Research efforts should continue to focus on strategies to help non-adhering women with young children achieve the physical activity recommendations and reduce time spent in sedentary behaviors.

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Fat-soluble vitamins A and E and health disparities in a cohort of pregnant women at delivery

Cited by 11 publications

References 54 publications

Disproportionate vitamin A deficiency in pregnant women of specific ethnicities in the United States and ethnic differences in allele frequencies of polymorphisms of vitamin A-related genes

Disproportionate vitamin A deficiency in pregnant women of specific ethnicities in the United States and ethnic differences in allele frequencies of polymorphisms of vitamin A-related genes

Disproportionate Vitamin A Deficiency in Women of Specific Ethnicities Linked to Differences in Allele Frequencies of Vitamin A-Related Polymorphisms

The impact of body mass index and sociodemographic factors on moderate-to-vigorous physical activity and sedentary behaviors of women with young children: A cross-sectional examination

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