Fat Necrosis of the Breast: A Pictorial Review of the Mammographic, Ultrasound, CT, and MRI Findings with Histopathologic Correlation

Kerridge, William D.; Kryvenko, Oleksandr N.; Thompson, Afua; Shah, Biren A.

doi:10.1155/2015/613139

Cited by 61 publications

(77 citation statements)

References 18 publications

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“…It is important to diagnose fat necrosis because it can often mimic carcinoma of the breast. 17 Karki et al noted 1% cases of fat necrosis. 10 Fat necrosis is found to be 0.8% of breast tumors.…”

Section: Discussionmentioning

confidence: 98%

“…We also noted similar findings in fat necrosis. 17 We advised follow up every 3 months for both the low and high risk categories, since some studies have the progression of the low risk category to carcinoma1. Hartmann et al stated, histologic features, the age at biopsy, and the degree of family history are the major determinants of the risk of breast cancer after the diagnosis of benign breast disease.…”

Section: Discussionmentioning

confidence: 99%

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Patterns and prevalence of benign breast disease in Western India

2017

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Background: Benign breast diseases constitute a heterogeneous group of disorders including developmental abnormality, epithelial and stromal proliferation, inflammatory lesions and neoplasm. Benign breast lesions deserve attention because of their high prevalence, their impact on women's life and due to cancerous potential of some histological types. Treatment of BBDS is preservation of breast tissue as far as possible in contrast to traumatizing mutilating surgeries in breast cancers. Methods: This study of 210 cases of histologically diagnosed benign breast lesions was carried out in the Department of Pathology, at tertiary care teaching hospital with attached peripheral hospitals in a metropolitan city of western India from August 2014 to August 2016. Results: Out of 210 benign lesions, 201 (95.7%) were found in females and 9 (4.3%) were found in males. Commonest benign breast lesion was fibroadenoma (77.62%), followed by fibrocystic disease (4.3%) and gynaecomastia (4.3%). Conclusions: Fibroadenoma is the most common benign breast disease. Most of the patients presented with painless lump in the breast in upper outer quadrant of the breast. Histopathology plays an important role in the diagnosis of benign breast diseases.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Patterns and prevalence of benign breast disease in Western India

2017

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“…36,76 Tissue damage caused by surgical trauma, radiotherapy, biopsy or tissue puncture can lead to fat necrosis, the radiographic appearance for which can commonly resemble malignancy. 77 While the incidence of fat necrosis in the breast is only 0.6% and represents 2.75% of all breast lesions, 78 its presence warrants due consideration, since it may affect a proportion (regardless of how small the proportion) of females adversely if mistaken for a malignant lesion upon screening.…”

Section: Patient Characteristicsmentioning

confidence: 99%

Is the false-positive rate in mammography in North America too high?

Le¹,

Mothersill²,

Seymour³

et al. 2016

BJR

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The practice of investigating pathological abnormalities in the breasts of females who are asymptomatic is primarily employed using X-ray mammography. The importance of breast screening is reflected in the mortality-based benefits observed among females who are found to possess invasive breast carcinoma prior to the manifestation of clinical symptoms. It is estimated that population-based screening constitutes a 17% reduction in the breast cancer mortality rate among females affected by invasive breast carcinoma. In spite of the significant utility that screening confers in those affected by invasive cancer, limitations associated with screening manifest as potential harms affecting individuals who are free of invasive disease. Disease-free and benign tumour-bearing individuals who are subjected to diagnostic work-up following a screening examination constitute a population of cases referred to as false positives (FPs). This article discusses factors contributing to the FP rate in mammography and extends the discussion to an assessment of the consequences associated with FP reporting. We conclude that the mammography FP rate in North America is in excess based upon the observation of overtreatment of in situ lesions and the disproportionate distribution of detriment and benefit among the population of individuals recalled for diagnostic work-up subsequent to screening. To address the excessive incidence of FPs in mammography, we investigate solutions that may be employed to remediate the current status of the FP rate. Subsequently, it can be suggested that improvements in the breast-screening protocol, medical litigation risk, image interpretation software and the implementation of image acquisition modalities that overcome superimposition effects are promising solutions.

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“…On DCE-MRI, fat necrosis shows homogeneous or heterogeneus enhancement. The imaging findings of fat necrosis can mimic breast malignity or IGM and biopsy should be needed for the diagnosis (6,24). Isolated abscess formation can also mimic IGM.…”

Section: Resultsmentioning

confidence: 99%