Fat Metabolism and the Sprue Syndrome

Treatment of Steatorrhoea in Crohn's Disease

“…Steatorrhoea, which was present in the three cases, has been observed previously in regional ileitis (Bockus, 1945;Frazer. 1949), andCrohn (1949) mentions tropical sprue in the differential diagnosis.…”

Fat-malabsorption in Congestive Cardiac Failure

“…First, the anorexia and consequently diminished food, and therefore fat, intake of these patients may have masked steatorrhoea. Such masking is well documented for low fat intakes (Wollaeger et al, 1947;Frazer, 1949;Weijers and van de Kamer, 1953 ;Crowe et al, 1956). Secondly, the discrepancy may represent a further failure of the 1-131 triolein test.…”

Benign Duodeno-colonic Fistula

“…A change in the bacterial flora might condition vitamin deficiency in the host either by suppression of those organisms which synthesize vitamins or by the overgrowth of others which require the vitamins for their own metabolism. An abnormal bacterial population in the bowel may also be important in producing steatorrhoea, and Frazer (1949) has suggested that bacterial lipolysis of dietary fat may produce irritant fatty acids which are poorly absorbed and cause diarrhoea and the oversecretion of mucus.…”