Fat Mass Is Negatively Associated with Cortical Bone Size in Young Healthy Male Siblings

Taes, Youri; Lapauw, Bruno; Vanbillemont, Griet; Bogaert, Veerle; Bacquer, Dirk De; Zmierczak, Hans‐Georg; Goemaere, Stefan; Kaufman, Jean‐Marc

doi:10.1210/jc.2008-2501

Cited by 88 publications

(82 citation statements)

References 36 publications

(45 reference statements)

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“…(1,2,7,8,(12)(13)(14)18,19) These associations were stronger for anatomically related sites of measurement (grip strength and distal radius, hip aBMD, and knee extension) and remained significant after adjustment for age, height, physical activity, and hormones. Our results confirm previous data (1,9) showing a positive relation between RASM and bone size. CSA was 0.72 SD lower in the lowest RASM quartile compared with the highest quartile, whereas the difference in total vBMD between the extreme quartiles was nonsignificant.…”

Section: Discussionsupporting

confidence: 92%

“…In young men, lean body mass correlated positively with Ct.Ar and negatively with Ct.vBMD at the distal radius and tibia (both measured by pQCT). (9) By contrast, in older men, grip strength correlated positively with Ct.vBMD at the distal radius and tibia measured by pQCT. Results are presented as adjusted means AE SD.…”

Section: Discussionmentioning

confidence: 82%

“…and of the grip strength to the variability of bone microarchitecture is limited. (9,10) However, the multivariate models permit us to remove the effect of several confounders that can be common determinants of, on one hand, muscle mass and strength and, on the other hand, of bone size and microarchitecture. In addition, the correlation between these parameters may be artifactually weakened by the intrinsic errors in their measurement.…”

Section: Discussionmentioning

confidence: 99%

“…In 677 male siblings aged 25 to 45 years, whole-body lean mass correlated positively with cortical area and thickness, and negatively with cortical density (all measured by pQCT) at the radius and tibia. (9) In 317 men aged 20 to 97 years, RASM was positively correlated with bone area and cortical thickness of the femoral neck, distal tibia, and distal radius after adjustment for age and physical activity. (10) In similar models, RASM correlated positively with trabecular number but negatively with trabecular thickness.…”

Section: Introductionmentioning

confidence: 93%

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Impaired bone microarchitecture at the distal radius in older men with low muscle mass and grip strength: The STRAMBO study

Szulc

Blaizot

Boutroy

et al. 2012

Journal of Bone and Mineral Research

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The aim was to study the association between bone microarchitecture and muscle mass and strength in older men. Volumetric bone mineral density (vBMD) and bone microarchitecture were assessed in 810 men aged !60 years at the distal radius by high-resolution peripheral computed tomography (HR-pQCT). Areal bone mineral density (aBMD) and appendicular muscle mass (ASM) were assessed by dual-energy X-ray absorptiometry (DXA). Relative ASM of the upper limbs (RASM-u.l.) was calculated as ASM of the upper limbs/ (height) 2 . Grip strength was measured by dynanometry. In multivariable models, men in the lowest RASM-u.l. quartile had lower crosssectional area (CSA), cortical area (Ct.Ar), cortical thickness (Ct.Th), and trabecular area (Tb.Ar) at distal radius compared with men in the highest quartile. The trends remained significant after adjustment for grip strength. Men in the lowest quartile of the normalized grip strength (grip strength/ [height] 2 ) had lower aBMD, total vBMD, Ct.Ar, Ct.Th, Tb.vBMD, and Tb.N, and higher Tb.Sp and Tb.Sp.SD. The associations for Ct.Ar, total vBMD, Ct.Th, Tb.vBMD, and Tb.Sp remained significant after adjustment for RASM-u.l. In the models including RASM-u.l. and normalized grip strength, CSA and Tb.Ar were associated with RASM-u.l. but not with the strength. Lower Ct.Th, Tb.vBMD, and Tb.N were associated with lower grip strength but not with RASM-u.l. Lower Ct.Ar was associated with lower grip strength and with lower RASM-u.l. In conclusion, in older men, low RASM-u.l. and low grip strength are associated with poor cortical and trabecular microarchitecture partly independently of each other, after adjustment for confounders. ß

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

See 2 more Smart Citations

Impaired bone microarchitecture at the distal radius in older men with low muscle mass and grip strength: The STRAMBO study

Szulc

Blaizot

Boutroy

et al. 2012

Journal of Bone and Mineral Research

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“…Moreover, and as opposed to our hypothesis, it was the only muscle parameter independently associated with periosteal circumference and thus overall bone size. Although strong correlations of (appendicular) lean mass with bone geometry have been previously described, the mechanisms underlying these associations are incompletely understood [13,32,33,40]. In general, DXA-derived estimates of leg lean mass reflect a combination of both potential local muscle activity and the overall individual's health status, body composition and physical activity level.…”

Section: Discussionmentioning

confidence: 99%

Association of Jumping Mechanography-Derived Indices of Muscle Function with Tibial Cortical Bone Geometry

et al. 2015

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Jumping mechanography has been developed to estimate maximum voluntary muscle forces. This study assessed associations of jumping mechanography-derived force and power measurements with tibial cortical bone geometry, compared to other estimates of muscle mass, size and function.Healthy men (n=181; 25-45 years) were recruited in a cross-sectional, population-based sibling-pair study. Muscle parameters include isokinetic peak torque of the quadriceps, DXA-derived leg lean mass, mechanography-derived peak jump force and power and pQCT-derived mid-tibial (66%) muscle cross-sectional area (CSA). Mid-tibial cortical bone parameters were assessed by pQCT. In age, height and weight-adjusted analyses, jump force and power correlated positively with cortical bone area, cortical thickness and polar strength strain index (SSIp) (ß=0.23-0.34,p≤0.001 for force; ß=0.25-0.30,p≤0.007 for power), and inversely with endosteal circumference adjusted for periosteal circumference (EC PC ) (ß=-0.16,p<0.001 for force; ß=-0.13,p=0.007 for power). Force but not power correlated with cortical over total bone area ratio (ß=0.25,p=0.002). Whereas leg lean mass correlated with all cortical parameters except cortical over total bone area ratio (ß=0.25-0.62,p≤0.004), muscle CSA only correlated with cortical bone area, periosteal circumference and SSIp (ß=0.21-0.26,p≤0.001), and quadriceps torque showed no significant correlations with the bone parameters. Multivariate models indicated that leg lean mass was independently associated with overall bone size and strength reflected by periosteal and endosteal circumference and SSIp (ß=0.32-0.55,p≤0.004), whereas jump force was independently associated with cortical bone size reflected by EC PC , cortical thickness and cortical over total bone area ratio (ß=0.13-0.28;p≤0.002). These data indicate that jumping mechanography provides relevant information about the relationship of muscle with bone geometry.

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Relationship between body mass, lean mass, fat mass, and limb bone cross‐sectional geometry: Implications for estimating body mass and physique from the skeleton

Pomeroy

Macintosh

Wells

et al. 2018

American J Phys Anthropol

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ObjectivesEstimating body mass from skeletal dimensions is widely practiced, but methods for estimating its components (lean and fat mass) are poorly developed. The ability to estimate these characteristics would offer new insights into the evolution of body composition and its variation relative to past and present health. This study investigates the potential of long bone cross‐sectional properties as predictors of body, lean, and fat mass.Materials and MethodsHumerus, femur and tibia midshaft cross‐sectional properties were measured by peripheral quantitative computed tomography in sample of young adult women (n = 105) characterized by a range of activity levels. Body composition was estimated from bioimpedance analysis.ResultsLean mass correlated most strongly with both upper and lower limb bone properties (r values up to 0.74), while fat mass showed weak correlations (r ≤ 0.29). Estimation equations generated from tibial midshaft properties indicated that lean mass could be estimated relatively reliably, with some improvement using logged data and including bone length in the models (minimum standard error of estimate = 8.9%). Body mass prediction was less reliable and fat mass only poorly predicted (standard errors of estimate ≥11.9% and >33%, respectively).DiscussionLean mass can be predicted more reliably than body mass from limb bone cross‐sectional properties. The results highlight the potential for studying evolutionary trends in lean mass from skeletal remains, and have implications for understanding the relationship between bone morphology and body mass or composition.

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Fat Mass Is Negatively Associated with Cortical Bone Size in Young Healthy Male Siblings

Abstract: Increased fat mass is associated with smaller bone size, challenging the view of a high bone mass index as a protective factor for osteoporosis, whereas lean mass was a consistent positive determinant of bone size.

Cited by 88 publications

References 36 publications

Impaired bone microarchitecture at the distal radius in older men with low muscle mass and grip strength: The STRAMBO study

Impaired bone microarchitecture at the distal radius in older men with low muscle mass and grip strength: The STRAMBO study

Association of Jumping Mechanography-Derived Indices of Muscle Function with Tibial Cortical Bone Geometry

Relationship between body mass, lean mass, fat mass, and limb bone cross‐sectional geometry: Implications for estimating body mass and physique from the skeleton

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