Fat grafting is a feasible technique for the sequelae of head and neck cancer treatment

Gutiérrez-Santamaría, Javier; Gridilla, Jorge Masiá; Romero, J. Pamias; López-de-Sagredo, J. Giralt; Atín, M.S. Bescós

doi:10.1016/j.jcms.2016.10.019

Cited by 28 publications

(32 citation statements)

References 19 publications

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“…Adipocyte‐derived stem cells found within fat grafts are able to differentiate into various cell lineages as well as secrete soluble mediators with angiogenic, immunosuppressive, and anti‐inflammatory properties . Several preliminary studies have demonstrated that autologous free fat transfer may significantly enhance the healing of pressure sores, critical limb ischaemia, and post‐radiation therapy scars . PRP in isolation has also been shown to have significant regenerative properties .…”

Section: Discussionmentioning

confidence: 99%

Systematic review of the efficacy of fat grafting and platelet‐rich plasma for wound healing

Smith

Kanapathy

Khajuria³

et al. 2018

International Wound Journal

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Adipose-derived stem cells found in fat grafts may have significant healing properties. When fat is combined with autologous platelet-rich plasma (PRP), there may be enhanced healing effects due to the pro-angiogenic and anti-inflammatory effects of PRP. This study aimed to evaluate the current evidence on fat grafting in combination with PRP for wound healing to establish the efficacy of this technique. A comprehensive search in the MEDLINE, EMBASE, CENTRAL, Science Citation Index, and Google Scholar databases (to March 2017) was conducted to identify studies on fat grafting and PRP for wound healing. Case series of less than 3 cases and studies only describing harvest technique were excluded. The database identified 571 articles, of which 3 articles that used a combination of fat and PRP for wound healing (1 RCT and 2 case series) were included in this review. A total of 69 wounds in 64 patients were treated with an average wound size of 36.32cm . Of these, 67% of wounds achieved complete healing. When reported, the mean time to healing was 7.5 weeks for those who underwent a single treatment. There were no significant complications in any patients. The combination of fat grafting and PRP may achieve adequate wound healing with relatively quick wound healing time compared with standard wound management options. However, evidence is extremely limited, and further studies are required to evaluate its efficacy for wound healing.

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Section: Discussionmentioning

confidence: 99%

Systematic review of the efficacy of fat grafting and platelet‐rich plasma for wound healing

Smith

Kanapathy

Khajuria³

et al. 2018

International Wound Journal

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“…The loss of facial volume, especially in the periorbital region, is an important component of aging and is due to the redistribution and atrophy of facial fat 16,17 . Correction of facial volume with fat may be considered an option due to its integration into tissues and its biocompatibility 18‐20 . Fat provides not only volume correction but offers an active and dynamic tissue composed of several different cell types, including adipocytes, fibroblasts, smooth muscle cells, endothelial cells, and adipogenic progenitor cells 7,8 …”

Section: Autologous Facial Fat Transfermentioning

confidence: 99%

“…The use of autologous fat for correction of facial volume may be an elegant technique for treating facial soft tissue contour deformities and volume deficits 6,18‐20,22‐25 . Its application in the face is particularly interesting because it allows for precise titration and injection 6,18,25 .…”

Section: Autologous Facial Fat Transfermentioning

confidence: 99%

The role of a shelf‐ready, human‐derived, soft tissue injectable adipose matrix for facial volume correction

Gold

Andriessen²,

Day

et al. 2020

J of Cosmetic Dermatology

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Background Synthetic soft tissue fillers frequently used to restore facial volume do not provide a regenerative framework, limiting their sustained efficacy. Autologous fat transfer for facial rejuvenation supports tissue regeneration but has unpredictable outcomes depending on the quality of harvesting, processing, and implantation. Aims Exploration of the pros and cons of available tissue fillers and the role of an injectable Allograft Adipose Matrix (AAM) for facial rejuvenation. Methods The results of a literature review conducted by two clinicians with extensive experience in this field were discussed by a panel of dermatologists and surgeons who regularly treat patients with signs and symptoms of facial aging. A manuscript was prepared and reviewed by the panel taking into account the evidence and their clinical experience treating patients for facial rejuvenation. Results Facial rejuvenation needs to address the volume deficiency and repositioning of ptotic soft tissues. Frequently used synthetic fillers are suitable candidates for improving the facial appearance of fine lines and for molding. A better understanding of facial volume loss has allowed the use of adipose fat cells for facial rejuvenation. The injectable AAM is readily available and provides a regenerative framework for sustainable results. Prospective clinical and randomized studies support the effective and safe use of AAM for facial rejuvenation. Conclusion AAM may offer an alternative to synthetic fillers and autologous fat implantation in the face without the cumbersome process of fat harvesting and processing. More robust studies are to confirm the positive results obtained in smaller studies using the soft tissue bio stimulatory injectable.

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“… 5 Several preliminary studies have demonstrated that autologous free fat transfer may significantly enhance healing of diabetic foot ulcers, 6 pressure sores, 7 and radiotherapy scars. 8 …”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Autologous Platelet-Rich Plasma and Fat Graft Preparation Methods

Luck

Smith

Mosahebi

2017

Plastic and Reconstructive Surgery - Global Open

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Fat grafting is a feasible technique for the sequelae of head and neck cancer treatment

Cited by 28 publications

References 19 publications

Systematic review of the efficacy of fat grafting and platelet‐rich plasma for wound healing

Systematic review of the efficacy of fat grafting and platelet‐rich plasma for wound healing

The role of a shelf‐ready, human‐derived, soft tissue injectable adipose matrix for facial volume correction

A Systematic Review of Autologous Platelet-Rich Plasma and Fat Graft Preparation Methods

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