Fat Grafting in Primary Cleft Lip Repair

Zellner, Elizabeth; Pfaff, Miles J.; Steinbacher, Derek M.

doi:10.1097/prs.0000000000001187

Cited by 42 publications

(46 citation statements)

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“…The efficacy of lipofilling to improve scar appearance has been investigated in 16 case reports or clinical trials (Balkin et al , ; Bollero et al , ; Bruno et al , ; Coleman, ; Guisantes et al , ; Klinger et al , ; Maione et al , ; Mazzola et al , ; Pallua et al , ; Phulpin et al , ; Ribuffo et al , ; Sardesai and Moore, ; Wang et al , ; Zellner et al , ; Table ). In 10 studies of these publications, comprising of a total of 156 patients, complications were recorded: in nine of these 10 studies no complications were recorded, whereas in one study with 12 patients there was a case of cellulitis reported as a complication.…”

Section: Lipofilling As a Methods To Treat Scarsmentioning

confidence: 99%

“…Only five well‐designed controlled studies had well‐defined objectives and outcome parameters, and had included both non‐treated (Balkin et al , ; Ribuffo et al , ; Zellner et al , ) or placebo (Bruno et al , ; Maione et al , ) controls. Four of these studies focused on clinical outcomes (Balkin et al , ; Maione et al , ; Ribuffo et al , ; Zellner et al , ) and are discussed below, and one addresses histological changes (Bruno et al , ) and is discussed in the next section.…”

Section: Lipofilling As a Methods To Treat Scarsmentioning

confidence: 99%

“…In two studies, performed under supervision of the same senior researcher (Balkin et al , ; Zellner et al , ), the effect of lipofilling as adjuvant procedure to reduce formation of new scars after surgery is evaluated. During primary cleft lip repair surgery, efficacy of lipofilling is examined by comparison of pre‐ and post‐operative pictures for residual cleft stigmata by a blinded reviewer panel.…”

Section: Lipofilling As a Methods To Treat Scarsmentioning

confidence: 99%

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The power of fat and its adipose-derived stromal cells: emerging concepts for fibrotic scar treatment

Spiekman

Dongen

Willemsen

et al. 2017

J Tissue Eng Regen Med

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Lipofilling or lipografting is a novel and promising treatment method for reduction or prevention of dermal scars after injury. Ample anecdotal evidence from case reports supports the scar‐reducing properties of adipose tissue grafts. However, only a few properly controlled and designed clinical trials have been conducted thus far on this topic. Also, the underlying mechanism by which lipofilling improves scar aspect and reduces neuropathic scar pain remains largely undiscovered. Adipose‐derived stromal or stem cells (ADSC) are often described to be responsible for this therapeutic effect of lipofilling. We review the recent literature and discuss anticipated mechanisms that govern anti‐scarring capacity of adipose tissue and its ADSC. Both clinical and animal studies clearly demonstrated that lipofilling and ADSC influence processes associated with wound healing, including extracellular matrix remodelling, angiogenesis and modulation of inflammation in dermal scars. However, randomized clinical trials, providing sufficient level of evidence for lipofilling and/or ADSC as an anti‐scarring treatment, are lacking yet warranted in the near future. © 2017 The Authors Journal of Tissue Engineering and Regenerative Medicine Published by John Wiley & Sons Ltd

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Section: Lipofilling As a Methods To Treat Scarsmentioning

confidence: 99%

Section: Lipofilling As a Methods To Treat Scarsmentioning

confidence: 99%

Section: Lipofilling As a Methods To Treat Scarsmentioning

confidence: 99%

See 1 more Smart Citation

The power of fat and its adipose-derived stromal cells: emerging concepts for fibrotic scar treatment

Spiekman

Dongen

Willemsen

et al. 2017

J Tissue Eng Regen Med

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“…117 Fat grafts have been shown to improve the appearance of existing scars in five well-designed controlled studies. [118][119][120][121][122] The mechanism of improvement is often reported to be due to the presence of ASCs, however there is a lack of evidence to draw definitive conclusions. 123 More clinical studies are required before cellbased therapy is used clinically.…”

Section: Cell-based Therapymentioning

confidence: 99%

Embryonic skin development and repair

Borrelli

Hong

et al. 2018

Organogenesis

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Fetal cutaneous wounds have the unique ability to completely regenerate wounded skin and heal without scarring. However, adult cutaneous wounds heal via a fibroproliferative response which results in the formation of a scar. Understanding the mechanism(s) of scarless wound healing leads to enormous clinical potential in facilitating an environment conducive to scarless healing in adult cutaneous wounds. This article reviews the embryonic development of the skin and outlines the structural and functional differences in adult and fetal wound healing phenotypes. A review of current developments made towards applying this clinical knowledge to promote scarless healing in adult wounds is addressed.

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“…In contrast, the use of simple WAT for clinical purposes is not subject to such strict legal restrictions in most countries, as long as it is used as an unpurified autologous lipo-transfer. Current clinical applications include scar treatment, breast reconstruction after breast cancer surgery, aesthetic rejuvenation, cleft-lip repair and liposculpture for body deformities [30,[33][34][35][36]. The treatment of bone defects, osteomyelitis or chronic wounds is being debated [13,30,[35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Differences in the Inflammatory Response of White Adipose Tissue and Adipose-Derived Stem Cells

Taha

Volkmer

Haas

et al. 2020

IJMS

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The application of liposuctioned white adipose tissue (L-WAT) and adipose-derived stem cells (ADSCs) as a novel immunomodulatory treatment option is the currently subject of various clinical trials. Because it is crucial to understand the underlying therapeutic mechanisms, the latest studies focused on the immunomodulatory functions of L-WAT or ADSCs. However, studies that examine the specific transcriptional adaptation of these treatment options to an extrinsic inflammatory stimulus in an unbiased manner are scarce. The aim of this study was to compare the gene expression profile of L-WAT and ADSCs, when subjected to tumor necrosis factor alpha (TNFα), and to identify key factors that might be therapeutically relevant when using L-WAT or ADSCs as an immuno-modulator. Fat tissue was harvested by liposuction from five human donors. ADSCs were isolated from the same donors and shortly subjected to expansion culture. L-WAT and ADSCs were treated with human recombinant TNFα, to trigger a strong inflammatory response. Subsequently, an mRNA deep next-generation sequencing was performed to evaluate the different inflammatory responses of L-WAT and ADSCs. We found significant gene expression changes in both experimental groups after TNFα incubation. However, ADSCs showed a more homogenous gene expression profile by predominantly expressing genes involved in immunomodulatory processes such as CCL19, CCL5, TNFSF15 and IL1b when compared to L-WAT, which reacted rather heterogeneously. As RNA sequencing between L-WAT and ADSCS treated with TNFα revealed that L-WAT responded very heterogeneously to TNFα treatment, we therefore conclude that ADSCs are more reliable and predictable when used therapeutically. Our study furthermore yields insight into potential biological processes regarding immune system response, inflammatory response, and cell activation. Our results can help to better understand the different immunomodulatory effects of L-WAT and ADSCs.

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Fat Grafting in Primary Cleft Lip Repair

Abstract: Therapeutic, III.

Cited by 42 publications

References 1 publication

The power of fat and its adipose-derived stromal cells: emerging concepts for fibrotic scar treatment

The power of fat and its adipose-derived stromal cells: emerging concepts for fibrotic scar treatment

Embryonic skin development and repair

Differences in the Inflammatory Response of White Adipose Tissue and Adipose-Derived Stem Cells

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