Fat Grafting in Orthognathic Surgery

Iyengar, Rajiv; Gabrick, Kyle; Bruckman, Karl C.; Steinbacher, Derek M.

doi:10.1097/scs.0000000000005362

Cited by 15 publications

(22 citation statements)

References 35 publications

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“…These phenomena coincided with those observed in granular fat grafting for in ammatory diseases. [72][73][74] The anti-in ammatory response effects may be traced to the adipose-derived stem cells (ADSCs), as well as intrinsic T cells and macrophages in adipose tissue, considering the characteristics of the adiposetissue origin of AT-EVs.…”

Section: Discussionmentioning

confidence: 99%

Preparation of Therapy-Grade Extracellular Vesicles from Adipose Tissue to Promote Diabetic Wound Healing

Pan¹,

Xu²,

Zheng³

et al. 2022

Preprint

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Background Treatment of diabetic wounds is a major challenge in clinical practice. Extracellular vesicles (EVs) from adipose-derived stem cells (ADSCs) have shown effectiveness in diabetic wound models. However, obtaining ADSC-EVs requires culturing vast numbers of cells, which is hampered by the need for expensive equipment and reagents, extended time cost, and complicated procedures before commercialization. Therefore, methods to extract EVs from discarded tissue need to be developed, for immediate application during surgery. For this reason, mechanical, collagenase-digestive, and effused methods were designed and compared for preparing therapy-grade EVs directly from adipose tissue. Methods Characteristics and quantities of EVs were detected by transmission electron microscopy, nanoparticle tracking analysis, and western blotting firstly. To investigate the biological effects of EVs on diabetic wound healing, angiogenesis, proliferation, migration, and inflammation-regulation assays were then evaluated in vitro, along with a diabetic wound healing mouse model in vivo. To further explore the potential therapeutic mechanism of EVs, miRNA expression profile of EVs were also identified and analyzed. Results The adipose tissue derived EVs (AT-EVs) were showed to qualify ISEV identification by NTA and western blotting and the AT-EVs yield from three methods was equal. EVs also showed promoting effects on biological processes related to diabetic wound healing, which depend on fibroblasts, keratinocytes, endothelial cells, and macrophages both in vitro and in vivo. We also observed enrichment of overlapping or unique miRNAs associated with diabetic wound healing for further investigation. Conclusion After comparative analyses, a mechanical method was proposed for preparing immediate clinical applicable EVs from adipose tissue that would result in reduced preparation time and lower cost, which could have promising application potential in treating diabetic wounds.

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Section: Discussionmentioning

confidence: 99%

Preparation of Therapy-Grade Extracellular Vesicles from Adipose Tissue to Promote Diabetic Wound Healing

Pan¹,

Xu²,

Zheng³

et al. 2022

Preprint

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“…Lastly, abdominal fat was harvested and injected into the lip, cheeks and labiomental crease. [3][4][5]…”

Section: Orthognathic Surgerymentioning

confidence: 99%

Segmental Cleft-orthognathic Surgery to Achieve Facial Balance, Fistula Closure, and Arch Unification

Parsaei

Maniskas

Reátegui

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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keletal discrepancies and residual fistulae are challenging to correct in adult cleft lip and palate (CLP) patients. This video demonstrates the presurgical planning and operative sequence of a two-piece Le Fort I osteotomy to achieve concurrent alveolar fistula closure, dental substitution, and correction of the anteroposterior discrepancy (See Video [online]). Alveolar bone grafting, fat grafting, and second-stage septorhinoplasty techniques are also highlighted.

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“…In this context, malocclusion has as one of the main etiological factors the pattern of facial growth [12,13]. Facial deformity, with destructive psychological and social potential, has a negative impact, resulting in social and psychological disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Orthognathic surgery and fat injection for corrective liposculpture: a systematic review

Lucchese¹,

Bisetto²,

Idalgo³

et al. 2022

MedNEXT

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Introduction: Orthognathic Surgery (OS) aims to correct deformities of the bones of the maxilla and mandible. In this scenario, fat grafting is a powerful tool for corrections and also for facial aesthetic improvement together or after OS. The benefits of fat grafting during orthognathic surgery; to maximize aesthetic results, minimize swelling and optimize wound healing. Objective: To analyze the main clinical studies on the benefits and risks of facial fat grafting in orthognathic surgery, to know the current state of the art. Methods: It followed a systematic literature review model on the main clinical findings of orthognathic surgery and fat grafting, according to the rules of PRISMA. The research was carried out from July to September 2022 and developed based on Google Scholar, Scopus, PubMed, Ovid, Scielo, and Cochrane Library, using scientific articles from 1986 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: 123 studies were analyzed, with only 32 medium and high-quality studies selected, according to GRADE rules, and with risks of bias that do not compromise scientific development, based on the Cochrane instrument. Studies have shown that OS aims to establish harmonious facial esthetics, excellent functional occlusion, and improved airway conditions. As an important adjunct to OS, fat grafting is becoming more and more common due to its antiinflammatory role and effects on facial swelling. High patient satisfaction with the results. Postoperative swelling resolved at week 12 in the fat graft group and persistent edema. The edema decrease over time, with almost complete resolution within 1 year, improvement in facial morphology, function, quality, and skin texture in most of their patients. The use of assisted lipo transfers containing mesenchymal stem cells derived from adipose tissue, enables improvement in skin quality, smoothing of wrinkles, pore size, and attenuation of pigmentation and resolution of scars. Furthermore, enrichment of the lipoaspirate with stem cells derived from adipose tissue increases graft retention. Conclusion: Most of the studies analyzed in this review study showed that fat grafting in orthognathic surgery is a safe and effective tool to improve wound healing, improve aesthetic results, present an anti-inflammatory effect and reduce edema.

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Fat Grafting in Orthognathic Surgery

Cited by 15 publications

References 35 publications

Preparation of Therapy-Grade Extracellular Vesicles from Adipose Tissue to Promote Diabetic Wound Healing

Preparation of Therapy-Grade Extracellular Vesicles from Adipose Tissue to Promote Diabetic Wound Healing

Segmental Cleft-orthognathic Surgery to Achieve Facial Balance, Fistula Closure, and Arch Unification

Orthognathic surgery and fat injection for corrective liposculpture: a systematic review

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