Fat Grafting for Treatment of Facial Scleroderma

Daumas, Aurélie; Magalon, Jérémy; Delaunay, Flore; Abellan, M. C.; Philandrianos, C.; Sabatier, Florence; Granel, B.; Magalon, G.

doi:10.1016/j.cps.2019.08.016

Cited by 29 publications

(29 citation statements)

References 31 publications

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“…The use of smaller cannulas, as proposed in the micro fat-grafting technique (14-gauge, 1 mm diameter harvesting cannula and 21-gauge, 0.8 mm diameter grafting cannula), is another approach to potentially optimize the surgical technique. It allows the selection of smaller fat lobules (500 μm in diameter) that maintain the volumetric effect but with enhanced regenerative properties [ 40 , 41 , 42 ]. The rationale for this technique is consistent with the work of Eto et al, aiming at implementing the “surviving and regenerating zones” of fat grafts composed of adipocytes and ASCs [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Regenerative Strategy for Persistent Periprosthetic Leakage around Tracheoesophageal Puncture: Is It an Effective Long-Term Solution?

Parrilla

Almadori

Longobardi

et al. 2021

Cells

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Autologous tissue-assisted regenerative procedures have been considered effective to close different types of fistula, including the leakage around tracheoesophageal puncture. The aim of this study was to retrospectively review 10 years of lipotransfer for persistent periprosthetic leakage in laryngectomized patients with voice prosthesis. Clinical records of patients who experienced periprosthetic leakage from December 2009 to December 2019 were reviewed. Patients receiving fat grafting were included. The leakage around the prosthesis was assessed with a methylene blue test. Twenty patients experiencing tracheoesophageal fistula enlargement were treated with fat grafting. At the one-month follow-up, all patients were considered improved with no leakage observed. At six months, a single injection was sufficient to solve 75% of cases (n 15), whereas 25% (n 5) required a second procedure. The overall success rate was 80% (n 16). Results remained stable for a follow-up of 5.54 ± 3.97 years. Fat grafting performed around the voice prosthesis, thanks to its volumetric and regenerative properties, is a valid and lasting option to solve persistent periprosthetic leakage.

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Section: Discussionmentioning

confidence: 99%

Regenerative Strategy for Persistent Periprosthetic Leakage around Tracheoesophageal Puncture: Is It an Effective Long-Term Solution?

Parrilla

Almadori

Longobardi

et al. 2021

Cells

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“…The regenerative approach to SSc with fat grafting has been investigated in several previous reports mainly focused on the treatment of facial and perioral lesions, such as microstomia and microcheilia [68,69]. However, researchers have also evaluated the role of adipose tissue transfer on DUs with impressive results.…”

Section: Discussionmentioning

confidence: 99%

Additional Treatment for Digital Ulcers in Patients with Systemic Sclerosis: A Prospective, Open-Label, Multi-Arm Study for the use of Platelet-Rich Plasma-Lipofilling and Ultrasound-Based Treatments

Pirrello

Schinocca

Scaturro

et al. 2021

Preprint

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Background: Local treatments such as ultraviolet-A (UVA) phototherapy, topical calcitriol, injection of autologous fat grafting, Platelet-Rich Plasma (PRP), hyaluronic acid (HA) and local ultrasound (US) treatment are considered alternative approaches for skin involvement in Systemic sclerosis (SSc).The aim of our study was to evaluate the efficacy of PRP injection and lipofilling or local ultrasound in the treatment of SSc-related digital ulcers (DUs). Methods: We enrolled 28 patients with SSc. At baseline time (T0), all patients were treated with Iloprost intravenous infusions. Then, six patients (group 1) received a first inoculation of PRP, after 15 days a second inoculation of PRP and after 15 days a third of lipofilling. Other six patients (group 2) received the three consecutive injections associated with a maintenance therapy with additional injections of PRP every 30 days for 12 months. Six patients continued only the Iloprost therapy (controls). Ten patients (group 3) underwent medical sessions with ultrasound treatment for 10 days. Clinical evaluation was assessed at baseline, after 3 and 12 months of treatment for all patients.Results: In our study have shown an improvement in cutaneous and microvascular level, in quality of life, in mobility of extremities of upper limbs and a reduction of administration of Iloprost after PRP-Lipofilling and US treatment.Conclusions: Our findings suggest that PRP, coupled with lipofilling, and ultrasound treatment in SSc patients, can be considered additional procedures in the management of DUs.

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“…Local injections of autologous SVF also improved RP, vascular flow, hand pain and finger edema in SSc patients ( 190 , 192 ). Combination of autologous SVF and platelet-rich plasma, which is reported to enhance ADSC proliferation ( 194 ), also increased capillary density and decreased vascular ectasia in SSc patients, suggesting induction of neoangiogenesis ( 196 ). When locally implanted, ADSCs secrete VEGF and fibroblast growth factor, which may support local angiogenesis ( 197 ).…”

Section: Fat Grafting and Stromal Vascular Fraction/adipose-derived Stem Cells-based Therapymentioning

confidence: 99%

Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing Strategies

Zanin-Silva

Santana-Gonçalves

Kawashima-Vasconcelos

et al. 2021

Front. Med.

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Systemic Sclerosis (SSc) is an autoimmune disease marked by dysregulation of the immune system, tissue fibrosis and dysfunction of the vasculature. Vascular damage, remodeling and inadequate endothelial repair are hallmarks of the disease. Since early stages of SSc, damage and apoptosis of endothelial cells (ECs) can lead to perivascular inflammation, oxidative stress and tissue hypoxia, resulting in multiple clinical manifestations. Raynaud's phenomenon, edematous puffy hands, digital ulcers, pulmonary artery hypertension, erectile dysfunction, scleroderma renal crisis and heart involvement severely affect quality of life and survival. Understanding pathogenic aspects and biomarkers that reflect endothelial damage in SSc is essential to guide therapeutic interventions. Treatment approaches described for SSc-associated vasculopathy include pharmacological options to improve blood flow and tissue perfusion and, more recently, cellular therapy to enhance endothelial repair, promote angiogenesis and heal injuries. This mini-review examines the current knowledge on cellular and molecular aspects of SSc vasculopathy, as well as established and developing therapeutic approaches for improving the vascular compartment.

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Fat Grafting for Treatment of Facial Scleroderma

Cited by 29 publications

References 31 publications

Regenerative Strategy for Persistent Periprosthetic Leakage around Tracheoesophageal Puncture: Is It an Effective Long-Term Solution?

Regenerative Strategy for Persistent Periprosthetic Leakage around Tracheoesophageal Puncture: Is It an Effective Long-Term Solution?

Additional Treatment for Digital Ulcers in Patients with Systemic Sclerosis: A Prospective, Open-Label, Multi-Arm Study for the use of Platelet-Rich Plasma-Lipofilling and Ultrasound-Based Treatments

Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing Strategies

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