Fat Grafting for Facial Filling and Regeneration

Coleman, Sydney R.; Katzel, Evan B.

doi:10.1016/j.cps.2015.04.001

Cited by 147 publications

(108 citation statements)

References 30 publications

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“…Despite these rising numbers, the efficacy of fat transplant for facial rejuvenation has been questioned due to the lack of objective corroborating data. 6,10 As a matter of fact, the outcome of fat transplant is unpredictable, concomitantly depending on many parameters that are difficult to evaluate. 10,26 For instance, anatomical locations of the fat depots and the methods used for adipose tissue harvest, processing and re-injection can interfere with the success of lipotransfer.…”

Section: Discussionmentioning

confidence: 99%

“…6,10 As a matter of fact, the outcome of fat transplant is unpredictable, concomitantly depending on many parameters that are difficult to evaluate. 10,26 For instance, anatomical locations of the fat depots and the methods used for adipose tissue harvest, processing and re-injection can interfere with the success of lipotransfer. 27,28 In particular, adipose tissue from the superficial adipocyte layer has distinctive metabolic functions and morphological structures compared with the deeper adipocyte layer.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, administration of small volumes (less than 0.1 ml per pass) of fat and multiple passes ensures improved fat graft take, since implanted tissue is easily vascularized and not exposed to prolonged hypoxia. 10,29,30 Cell-assisted lipotransfer, a procedure in which stromal vascular fraction cells are isolated and then mixed with adipose-tissue before re-injection, has been suggested to improve graft take. 31 However, the process to isolate ASCs from adipose tissue by collagenase digestion cannot be considered as "minimal manipulation" and requires compliance with good manufacturing process technical standards and regulatory limitations.…”

Section: Discussionmentioning

confidence: 99%

“…Postoperative swelling is considered unavoidable in fat transplantation procedure 10 and it was observed to different extents in all of the patients participating in the study. Swelling spontaneously resolved in approximately 2-3 weeks.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…How adipose tissue transplantation exerts its beneficial effects on skin quality and texture is not completely understood. 10 Therefore, further studies aimed to define valid means to improve fat graft survival and to evaluate its effects on skin aging are required. A key role in tissue regeneration has been ascribed to soluble factors produced by implanted fat and to the presence of adipose-derived stromal and stem cells (ASCs) able to promote soft tissue remodeling.…”

Section: Introductionmentioning

confidence: 99%

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Facial skin rejuvenation by autologous dermal microfat transfer in photoaged patients: Clinical evaluation and skin surface digital profilometry analysis

Trivisonno¹,

Rossi²,

Monti³

et al. 2017

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Please cite this article as: Trivisonno, A.; Rossi, A.; Monti, M.; Di Nunno, D.; Desouches, C.; Cannistra, C.; Toietta, G. Facial skin rejuvenation by autologous dermal microfat transfer in photoaged patients: Clinical evaluation and skin surface digital profilometry analysis. Journal of Plastic Reconstructive and Aesthetic Surgery 2017, 70, 1118-1128. DOI: 10.1016/j.bjps.2017 http://www.sciencedirect.com/science/article/pii/S1748681517301559 M A N U S C R I P T A C C E P T E D M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 2 SUMMARYCumulative, long-term exposure to solar ultraviolet radiation promotes premature skin aging characterized by wrinkle formation and reduced skin elasticity. In this study, we assessed whether microfat transfer could improve dermal and subcutaneous tissue thickness loss associated with photoaging. Twenty one patients affected by facial photoaging (photodamage grade II-IV; age range 35-62 years; 19 females, 2 males; all of Caucasian origin) were treated using minimally-invasive autologous dermal white fat transfer harvested with a recently designed microcannula. The results were determined by clinical assessment, patient self-evaluation and quantified by the Antera 3D ® dermal digital device for non-invasive, objective, reliable and accurate assessment of facial skin texture, color and wrinkle characteristics. Compared with the pretreatment condition, the increment in soft tissue volume and improvement in skin quality and texture was assessed by a dermatologist after treatment. In addition, instrumental evaluation by digital skin profilometry of the treated areas revealed:a 41% reduction in average wrinkle depth (7.29 ± 1.04 x 10 -2 mm pre-treatment vs. 4.31 ± 1.16 x 10 -2 mm at 90 days post-treatment; p < 0.001), improved skin texture, more homogeneous and uniform skin color and declined facial hemoglobin and melanin concentrations. The majority of patients (above 90%) reported improvements in self-perception. No significant complications were reported throughout the study. In conclusion, by using digital profilometry analysis as an objective and innovative tool to determine the outcome of treatment, we demonstrated that autologous microfat transfer is a safe and well-tolerated procedure with measurable beneficial effects on facial skin aging.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Facial skin rejuvenation by autologous dermal microfat transfer in photoaged patients: Clinical evaluation and skin surface digital profilometry analysis

Trivisonno¹,

Rossi²,

Monti³

et al. 2017

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Use of Condensed Nanofat Combined With Fat Grafts to Treat Atrophic Scars

2018

JAMA Facial Plast Surg

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In addition to the physical deformity, there is often great psychological burden of facial scars for patients. In this study, we use condensed nanofat combined with fat grafts in a novel technique to improve atrophic facial scars by raising both the surface and the bottom of the affected area.OBJECTIVE To assess whether the use of condensed nanofat combined with fat grafting can be effective in treating atrophic facial scars from both an aesthetic and a functional perspective. DESIGN, SETTING, AND PARTICIPANTSIn this prospective case series of 20 patients with 25 atrophic facial scars, each scar was treated with condensed nanofat combined with fat grafts at the

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Fat Grafting

Zellner¹,

Steinbacher²

2019

Aesthetic Orthognathic Surgery and Rhinoplasty

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Fat Grafting for Facial Filling and Regeneration

Cited by 147 publications

References 30 publications

Facial skin rejuvenation by autologous dermal microfat transfer in photoaged patients: Clinical evaluation and skin surface digital profilometry analysis

Facial skin rejuvenation by autologous dermal microfat transfer in photoaged patients: Clinical evaluation and skin surface digital profilometry analysis

Use of Condensed Nanofat Combined With Fat Grafts to Treat Atrophic Scars

Fat Grafting

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