Fasting Reduces Plasma Leptin- and Ghrelin-Immunoreactive Peptide Concentrations of the Burbot (Lota lota) at 2°C But Not at 10°C

Nieminen, Petteri; Mustonen, Anne‐Mari; Hyvärinen, Heikki

doi:10.2108/zsj.20.1109

Cited by 59 publications

(34 citation statements)

References 33 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, fasting reduces leptin levels in plasma, adipose tissue and stomach, while overfeeding is accompanied by increased leptin concentrations in mammals (Ahima & Osei 2004). In fish, plasma leptin immunoreactive peptide was also reduced by 2 weeks fasting in green sunfish (Johnson et al 2000) and burbot (Nieminen et al 2003). Moreover, a positive correlation between blood leptin concentration and adiposity has been found in bluegill and white crappie (Johnson et al 2000).…”

Section: Introductionmentioning

confidence: 98%

Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)

Pedro¹,

Martínez‐Álvarez²,

Delgado³

2006

Journal of Endocrinology

132

View full text Add to dashboard Cite

The purpose of the present study was to elucidate the possible role of leptin in food intake and body weight regulation in goldfish. We examined the effects of i.c.v. or i.p. acute leptin administration on food intake in fooddeprived goldfish at different time intervals post-injection (0-2, 2-8 and 0-8 h). Food intake was reduced by i.p. administered leptin (1 µg) at 8 h post-injection, without statistically significant differences after i.c.v. treatment. The present study shows for the first time in a teleost that chronic (10 days) leptin treatment (i.p.) reduces food intake, body weight gain, specific growth rate and food efficiency ratio. Moreover, lipid and carbohydrate metabolism seems to be regulated by leptin in fish.Chronic leptin treatment increased lipid mobilization and carbohydrate storage as hepatic and muscle glycogen. Finally, leptin could mediate its actions on energy homeostasis in fish, at least in part, through interactions with hypothalamic catecholamines, since chronic leptin treatment reduced both hypothalamic noradrenergic and dopaminergic turnover without significant modifications in hypothalamic serotoninergic and neuropeptide Y (NPY) systems. In summary, our results suggest that leptin can regulate feeding behaviour and body weight homeostasis in fish.

show abstract

Section: Introductionmentioning

confidence: 98%

Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)

Pedro¹,

Martínez‐Álvarez²,

Delgado³

2006

Journal of Endocrinology

132

View full text Add to dashboard Cite

show abstract

“…Only recently a fish leptin gene was identified (Kurokawa et al, 2005) and leptin-like immunoreactivity was found in the blood, brain, heart, liver, gut, and plasma of fish (Bosi et al, 2004;Ferrando et al, 2009;Huising et al, 2006;Johnson et al, 2000;Kurokawa et al, 2005;Muruzá bal et al, 2002;Mustonen et al, 2002;Nieminen et al, 2003) and in salmon adipocytes (Vegusdal et al, 2003). Several leptin roles were suggested in fish (Peyon et al, 2001;Volkoff et al, 2003;Weil et al, 2003), but its involvement in food intake and body weight is still controversial due to support by various authors (De Pedro et al, 2006;Ferrando et al, 2009;Volkoff et al, 2003) and denied by others (Baker et al, 2000;Silverstein and Plisetskaya, 2000;Londraville and Duvall, 2002).…”

Section: Introductionmentioning

confidence: 99%

Leptin‐like immunoreactivity in the muscle of juvenile sea bass (Dicentrarchus labrax)

Gambardella

Ferrando

Gallus

et al. 2010

Microscopy Res & Technique

View full text Add to dashboard Cite

The mammalian hormone, leptin, is mainly synthesized in adipose tissue along with other tissues. Leptin plays a role in numerous processes such as in the control of food intake, homeostasis, immune function and reproduction. In this study, we detected and localized leptin immunoreactivity to the muscle of early juvenile sea bass (Dicentrarchus labrax) by Western blot analysis and immunohistochemistry. A leptin immunopositive band with a molecular weight of approximately 16 kDa, corresponding to mammalian leptin, was identified in trunk skeletal muscle homogenate. Furthermore, leptin immunopositive cells were detected in the endomysium of skeletal muscular fibers. These cells showed immunostained cytoplasmic granules and roundish and oval nuclei. The most intense immunostaining was observed in the endomysial space among the superficial red muscular fibers of the trunk. These findings suggest that in early juvenile sea bass, leptin is mostly produced by skeletal muscles. Therefore, during the developmental stage lacking adipose tissue, skeletal muscles can be considered an important source of leptin. As already suggested in mammals, we can hypothesize the potential roles of leptin not only in energy expenditure for muscle contraction but also during muscle differentiation and growth.

show abstract

“…Volkoff and Peter (2001) showed that the central injection of leptin increased CART mRNA in the optic tectum, hypothalamus, and olfactory bulbs, and suggested that CART might serve as a leptinregulated satiety factor in goldfish. Plasma leptin was reduced in green sunfish and burbot following fasting for 2 weeks (Johnson et al, 2000;Nieminen et al, 2003).…”

mentioning

confidence: 99%

Cocaine‐ and amphetamine‐regulated transcript peptide (CART) in the telencephalon of the catfish, Clarias gariepinus: Distribution and response to fasting, 2‐deoxy‐D‐glucose, glucose, insulin, and leptin treatments

Subhedar

Barsagade

Singru

et al. 2011

J of Comparative Neurology

View full text Add to dashboard Cite

The cocaine- and amphetamine-regulated transcript peptide (CART)-containing system in the forebrain of Clarias gariepinus was studied with immunocytochemistry. While the immunoreactivity was prominently seen in the neurons of the entopeduncular nucleus (EN) located in the ventral telencephalon, CART-immunoreactive fibers were widely distributed in the dorsal and ventral telencephalon. In view of the established role of CART in energy metabolism, we investigated the response of the CART immunoreactive system to positive and negative nutritional conditions. Neurons of the EN and fibers in the different areas of the telencephalon showed significant reduction in CART immunoreactivity following 48 hours food deprivation, or 2 hours following intracranial administration of 2-deoxy-D-glucose (2DG, 100 ng/g body weight, a metabolic antagonist of glucose). However, intracranial injection of glucose (100 ng/g body weight) resulted in a distinct increase in CART immunoreactivity in these components. In mammals, insulin and leptin have been recognized as adiposity agents that convey peripheral energy status-related information to brain. Intracranial administration of insulin (3 mU/fish) and leptin (10 ng/g body weight) significantly increased CART immunoreactivity in the EN neurons and in the fiber network within 2 hours. Superfusion of the EN-containing tissue fragments in the medium enriched in glucose, insulin, or leptin evoked a significant increase in CART immunoreactivity in the EN neurons, but 2DG reduced the immunoreactivity. We suggest that CART-containing neurons of the EN, and fibers in the telencephalon, may process the energy status-related information and contribute to satiety.

show abstract

Fasting Reduces Plasma Leptin- and Ghrelin-Immunoreactive Peptide Concentrations of the Burbot (Lota lota) at 2°C But Not at 10°C

Cited by 59 publications

References 33 publications

Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)

Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)

Leptin‐like immunoreactivity in the muscle of juvenile sea bass (Dicentrarchus labrax)

Cocaine‐ and amphetamine‐regulated transcript peptide (CART) in the telencephalon of the catfish, Clarias gariepinus: Distribution and response to fasting, 2‐deoxy‐D‐glucose, glucose, insulin, and leptin treatments

Contact Info

Product

Resources

About